Results 61 to 70 of about 1,444,803 (306)

Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21.

PLoS ONE, 2012
Metazoan mitosis requires remodelling of sub-cellular structures to ensure proper division of cellular and genetic material. Faults often lead to genomic instability, cell cycle arrests and disease onset.
Veerle De Wever, David C Lloyd, Isha Nasa, Mhairi Nimick, Laura Trinkle-Mulcahy, Robert Gourlay, Nick Morrice, Greg B G Moorhead   +7 more
doaj   +1 more source

Targeting Protein Phosphatase 1 in Heart Failure [PDF]

Circulation Research, 2005
See related article, pages 756–766 Over the past three decades the treatment of heart failure has shifted from a palliative care approach to a more successful focus on neurohormonal modulation through drugs that inhibit β-adrenergic, angiotensin, and aldosterone signaling.
openaire   +2 more sources

Folding of Intrinsically Disordered Protein Phosphatase 1 Regulatory Proteins [PDF]

Current Physical Chemistry, 2012
Intrinsically disordered but biologically active proteins, commonly referred to as IDPs, are readily identified in many biological systems and play critical roles in multiple protein regulatory processes. While disordered in their unbound states, IDPs often, but not always, fold upon binding with their protein interaction partners. Here, we discuss how
Wolfgang, Peti, Angus C, Nairn, Rebecca, Page   +2 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]

, 2010
Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Travis Jerde, Wade Bushman, Travis J. Jerde, Zhong Wu, Dan Theodorescu   +4 more
core   +2 more sources

Microcystins: Potent xenobiotics [PDF]

Archive of Oncology, 2011
Having in mind that exposure to low levels of microcystin in drinking water represents the health risk for people, microcystins can be observed as potent xenobiotics.
Ilić Maja, Svirčev Zorica, Baltić Vladimir   +2 more
doaj   +1 more source

Identification of AKAP79 as a Protein Phosphatase 1 Catalytic Binding Protein [PDF]

Biochemistry, 2011
The ubiquitously expressed and highly promiscuous protein phosphatase 1 (PP1) regulates many cellular processes. Targeting PP1 to specific locations within the cell allows for the regulation of PP1 by conferring substrate specificity. In the present study, we identified AKAP79 as a novel PP1 regulatory subunit.
Andrew V, Le, Steven J, Tavalin, Kimberly L, Dodge-Kafka   +2 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

Frontiers in Microbiology, 2019
Ebola virus (EBOV) is a non-segmented negative-sense RNA virus that causes a severe human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of the Congo has resulted to date in over 2500 confirmed cases including over 1500 ...
Xionghao Lin, Xionghao Lin, Tatiana Ammosova, Tatiana Ammosova, Tatiana Ammosova, Meng S. Choy, Colette A. Pietzsch, Andrey Ivanov, Asrar Ahmad, Yasemin Saygideğer, Namita Kumari, Dmytro Kovalskyy, Aykut Üren, Wolfgang Peti, Alexander Bukreyev, Sergei Nekhai, Sergei Nekhai   +16 more
doaj   +1 more source

Protein phosphatase 1 regulates the stability of the circadian protein PER2 [PDF]

Biochemical Journal, 2006
The circadian clock is regulated by a transcription/translation negative feedback loop. A key negative regulator of circadian rhythm in mammals is the PER2 (mammalian PERIOD 2) protein. Its daily degradation at the end of the night accompanies de-repression of transcription. CKIϵ (casein kinase I ϵ) has been identified as the kinase that phosphorylates
Monica, Gallego, Heeseog, Kang, David M, Virshup   +2 more
openaire   +2 more sources