Results 51 to 60 of about 1,442,861 (307)

A unique kelch domain phosphatase in plasmodium regulates ookinete morphology, motility and invasion [PDF]

, 2012
Signalling through post-translational modification (PTM) of proteins is a process central to cell homeostasis, development and responses to external stimuli.
Heli J. Vaikkinen (137832), Nisha Philip (137829), Laurence Tetley, Tetley, L., Waters, A.P., Vaikkinen, Heli J, Tetley, Laurence, Waters, Andrew P., Nisha Philip, Vaikkinen, H.J., Andrew P. Waters (15293), Laurence Tetley (37791), Heli J Vaikkinen, Philip, N., Philip, Nisha, Andrew P Waters   +15 more
core   +1 more source

Protein Phosphatase 1 δ is Associated with Focal Adhesions [PDF]

Cell Adhesion and Communication, 1998
In all mammalian cells protein phosphatase-1 (PP1) exists in three isoforms, defined as alpha, gamma 1 and delta. Immunofluorescence studies with isoform-specific antibodies indicated that delta, but not alpha or gamma 1, is enriched at focal adhesions in HeLa cells, fibroblasts, endothelial cells and keratinocytes.
VILLA, EMMA, TOGNARINI M., CECCHINI G., MARCHISIO P. C.   +3 more
openaire   +3 more sources

Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation.

PLoS ONE, 2013
In human and experimental heart failure, the activity of the type 1 phosphatase is significantly increased, associated with dephosphorylation of phospholamban, inhibition of the sarco(endo)plasmic reticulum Ca(2+) transport ATPase (SERCA2a) and depressed
Elizabeth Vafiadaki, Demetrios A Arvanitis, Despina Sanoudou, Evangelia G Kranias   +3 more
doaj   +1 more source

Liposomal C6 Ceramide Activates Protein Phosphatase 1 to Inhibit Melanoma Cells. [PDF]

PLoS ONE, 2016
Melanoma is one common skin cancer. In the present study, the potential anti-melanoma activity by a liposomal C6 ceramide was tested in vitro. We showed that the liposomal C6 (ceramide) was cytotoxic and anti-proliferative against a panel of human ...
Fangzhen Jiang, Kai Jin, Shenyu Huang, Qi Bao, Zheren Shao, Xueqing Hu, Juan Ye   +6 more
doaj   +1 more source

Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases? [PDF]

, 2008
Background: Tartrate-resistant acid phosphatases (TRAcPs), also known as purple acid phosphatases (PAPs), are a family of binuclear metallohydrolases that have been identified in plants, animals and fungi. The human enzyme is a major histochemical marker
David A Hume, Jodie Robinson, Gerhard Schenk, Hadler, K.ieran S., Burrows, Allan, Cassady A Ian, Hadler, K. S., Huber, Thomas, Guddat, L. W., Weber, J., Allan Burrows, Flanagan, J. U., Kelly Gregory, Robinson, J., Schenk Gerhard, Hume David A, Gregory Kelly, Robinson, Jodie, Huber Thomas, Guddat, Luke W., Burrows, A., Hadler, Kieran S., Burrows Allan, A Ian Cassady, Guddat, Luke W, Luke W Guddat, Hume, David A, Hume, D. A., Hume, David A., Kieran S Hadler, Flanagan, Jack U., Weber Jane, Robinson Jodie, Schenk, Gerhard, Kelly, Gregory, Hadler Kieran S, Jack U Flanagan, Jane Weber, Weber, Jane, Cassady, A. Ian, Cassady, A. I., Schenk, G., Guddat Luke W, Flanagan, Jack U, Flanagan Jack U, Huber, T., Hadler, Kieran S, Thomas Huber, Kelly, G., Cassady, Alan Ian   +49 more
core   +1 more source

Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line

Cancer Cell International, 2003
Background One of the major cellular serine/threonine protein phosphatases is protein phosphatase type 1 (PP1). Studies employing many eukaryotic systems all point to a crucial role for PP1 activity in controlling cell cycle progression.
Klover Peter, Messing Edward M, Sowden Mark P, Reeder Jay E, Villa-Moruzzi Emma, Ludlow John W   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Inhibition of protein phosphatase-1 and -2A by ellagitannins: structure-inhibitory potency relationships and influences on cellular systems

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Several ellagitannins inhibited the activity of protein phosphatase-1 (PP1) and -2 A (PP2A) catalytic subunits (PP1c and PP2Ac) with preferential suppression of PP1c over PP2Ac.
Zoltán Kónya, Bálint Bécsi, Andrea Kiss, Dániel Horváth, Mária Raics, Katalin E. Kövér, Beáta Lontay, Ferenc Erdődi   +7 more
doaj   +1 more source

Protein phosphatase-1α interacts with and dephosphorylates polycystin-1.

PLoS ONE, 2012
Polycystin signaling is likely to be regulated by phosphorylation. While a number of potential protein kinases and their target phosphorylation sites on polycystin-1 have been identified, the corresponding phosphatases have not been extensively studied ...
Stephen C Parnell, Sanjeev Puri, Sanjeev Puri, Darren P Wallace, James P Calvet   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source