Results 71 to 80 of about 1,442,861 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana

, 2010
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
Juliane Schroeder, Plevin Robin, Kurnik Magdalena, H. Adrienne McGachy, Shweash, M.S., Cadalbert Laurence C., H Adrienne McGachy, Callum M Sloss, James Alexander, Shweash Muhannad, Bryant, C.E., Laurence C Cadalbert, Cadalbert, L.C., Clare E Bryant, Laurence C. Cadalbert, Alexander, James, Mashael S Al-Mutairi, Muhannad Shweash, Al-Mutairi Mashael S., Al-Mutairi, M.S., Schroeder Juliane, Callum M. Sloss, Alexander James, Robin Plevin, Sloss Callum M., Schroeder, J., Plevin, R.J., Sloss, C.M., Mashael S. Al-Mutairi, McGachy, H.A., Clare E. Bryant, McGachy H. Adrienne, Bryant Clare E., Magdalena Kurnik, Kurnik, M.   +34 more
core   +1 more source

Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task [PDF]

, 2006
The regulation and function of the calcium-dependent phosphatase calcineurin (CaN, protein phosphatase 2B) in learning and memory remain unclear, although recent work indicates that CaN may play a differential role in training and reversal training.
Havekes, Robbert,, Luiten, Paul G. M., Havekes, Robbert, Nijholt, Ingrid M.,, van der Zee, Eddy A., Havekes, Robbert; id_orcid, Nijholt, Ingrid M., Luiten, Paul G.M.,, Zee, Eddy A. van der,   +8 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2

, 2002
Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved.
Zhang, S., Wen, G., Minichiello, L., Zhang, Si Qing, Wen, Gengyun, Araki, T., Klein, R., Tsiaras, B., Neel, Benjamin G, Neel, B., Araki, Toshiyuki, Klein, Ruediger, Minichiello, Liliana, Tsiaras, William G   +13 more
core   +1 more source

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization

Proteomes, 2018
Glutamatergic projections from the cortex and dopaminergic projections from the substantia nigra or ventral tegmental area synapse on dendritic spines of specific GABAergic medium spiny neurons (MSNs) in the striatum.
Darryl S. Watkins, Jason D. True, Amber L. Mosley, Anthony J. Baucum   +3 more
doaj   +1 more source

Protein phosphatase 1 regulators in DNA damage signaling [PDF]

Cell Cycle, 2011
In response to DNA damaging agents and endogenous DNA lesions, human cells activate signaling cascades and repair mechanisms to help maintain genomic integrity. Phosphorylation plays a major role in DNA damage signaling, and the role of Ser/Thr kinases, including ATM, ATR, CHK1, CHK2 and DNA-PK, is particularly well documented. While these kinases have
Thomas, Küntziger, Helga B, Landsverk, Philippe, Collas, Randi G, Syljuåsen   +3 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ramipril increases the protein level of skeletal muscle IRS-1 and alters protein tyrosine phosphatase activity in spontaneously hypertensive rats [PDF]

, 2000
To investigate mechanisms by which angiotensin converting enzyme (ACE)-inhibition increases insulin sensitivity, spontaneously hypertensive (SH) rats were treated with or without ramipril (1 mg/kg per day) for 12 weeks. Insulin binding and protein levels
Krützfeldt, J, Raasch, W, Klein, H H
core   +1 more source

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

Frontiers in Microbiology, 2019
Ebola virus (EBOV) is a non-segmented negative-sense RNA virus that causes a severe human disease. The ongoing EBOV outbreak in the Eastern part of Democratic Republic of the Congo has resulted to date in over 2500 confirmed cases including over 1500 ...
Xionghao Lin, Xionghao Lin, Tatiana Ammosova, Tatiana Ammosova, Tatiana Ammosova, Meng S. Choy, Colette A. Pietzsch, Andrey Ivanov, Asrar Ahmad, Yasemin Saygideğer, Namita Kumari, Dmytro Kovalskyy, Aykut Üren, Wolfgang Peti, Alexander Bukreyev, Sergei Nekhai, Sergei Nekhai   +16 more
doaj   +1 more source