Results 31 to 40 of about 1,444,803 (306)

Analysis of the structure and function of protein phosphatase 2A [PDF]

, 2004
One of the hallmarks of a living organism is the ability to respond to intra- or extracellular changes. These responses involve panoply of enzymes mediating signals through the cell and regulating distinct cellular functions.
Schmidt, Karsten
core   +1 more source

Protein phosphatase 1 β paralogs encode the zebrafish myosin phosphatase catalytic subunit.

PLoS ONE, 2013
BackgroundThe myosin phosphatase is a highly conserved regulator of actomyosin contractility. Zebrafish has emerged as an ideal model system to study the in vivo role of myosin phosphatase in controlling cell contractility, cell movement and epithelial ...
Vaishali Jayashankar, Michael J Nguyen, Brandon W Carr, Dale C Zheng, Joseph B Rosales, Joshua B Rosales, Douglas C Weiser   +6 more
doaj   +1 more source

Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

Cellular Physiology and Biochemistry, 2013
Background/Aims: The linoleic acid derivative DCP-LA selectively activates PKCε and inhibits protein phosphatase 1 (PP1). In the present study, we have newly synthesized phosphatidyl-ethanolamine, -serine, -choline, and -inositol containing DCP-LA at the
Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Tomoyuki Nishizaki   +5 more
doaj   +1 more source

Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells [PDF]

, 2003
In view of the common regulatory mechanism that induces transcription of tie mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit.
Patric Turowski, Franckhauser, Céline, Ned J. C. Lamb, Lamb, Ned,, Celine Franckhauser, Fernandez, A, Lamb, NJC, Turowski, P, Fernandez, Anne, Turowski, Patric, Morris, May, Franckhauser, C, Vaglio, P, Vaglio, Philippe, Morris, MC, Lamb, Ned, J., Anne Fernandez, May C. Morris, Anne Fern, Philippe Vaglio   +19 more
core   +1 more source

Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. [PDF]

PLoS Genetics, 2017
In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C.
Nina Peel, Jyoti Iyer, Anar Naik, Michael P Dougherty, Markus Decker, Kevin F O'Connell   +5 more
doaj   +1 more source

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana [PDF]

, 2010
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
Juliane Schroeder, Plevin Robin, Kurnik Magdalena, H. Adrienne McGachy, Shweash, M.S., Cadalbert Laurence C., H Adrienne McGachy, Callum M Sloss, James Alexander, Shweash Muhannad, Bryant, C.E., Laurence C Cadalbert, Cadalbert, L.C., Clare E Bryant, Laurence C. Cadalbert, Alexander, James, Mashael S Al-Mutairi, Muhannad Shweash, Al-Mutairi Mashael S., Al-Mutairi, M.S., Schroeder Juliane, Callum M. Sloss, Alexander James, Robin Plevin, Sloss Callum M., Schroeder, J., Plevin, R.J., Sloss, C.M., Mashael S. Al-Mutairi, McGachy, H.A., Clare E. Bryant, McGachy H. Adrienne, Bryant Clare E., Magdalena Kurnik, Kurnik, M.   +34 more
core   +1 more source

TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network

Biology Open, 2013
Summary Reversible phosphorylation plays an important role as a mechanism of intracellular control in eukaryotes. PPP1, a major eukaryotic Ser/Thr-protein phosphatase, acquires its specificity by interacting with different protein regulators, also known ...
Luís Korrodi-Gregório, Sandra I. Vieira, Sara L. C. Esteves, Joana V. Silva, Maria João Freitas, Ann-Kristin Brauns, Georg Luers, Joana Abrantes, Pedro J. Esteves, Odete A. B. da Cruz e Silva, Margarida Fardilha, Edgar F. da Cruz e Silva   +11 more
doaj   +1 more source

PPM1D Knockdown Suppresses Cell Proliferation, Promotes Cell Apoptosis, and Activates p38 MAPK/p53 Signaling Pathway in Acute Myeloid Leukemia

Technology in Cancer Research & Treatment, 2020
Objectives: This study was to explore the effect of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D knockdown on proliferation and apoptosis as well as p38 MAPK/p53 signaling pathway in acute myeloid leukemia.
Bin Li MD, Jie Hu MD, Di He BS, Qi Chen MD, Suna Liu BS, Xiaoling Zhu MD, Meijia Yu MD   +6 more
doaj   +1 more source

Regulation of Synaptic Strength by Protein Phosphatase 1 [PDF]

Neuron, 2001
We investigated the role of postsynaptic protein phosphatase 1 (PP1) in regulating synaptic strength by loading CA1 pyramidal cells either with peptides that disrupt PP1 binding to synaptic targeting proteins or with active PP1. The peptides blocked synaptically evoked LTD but had no effect on basal synaptic currents mediated by either AMPA or NMDA ...
Morishita, Wade, Connor, John H, Xia, Houhui, Quinlan, Elizabeth M, Shenolikar, Shirish, Malenka, Robert C   +5 more
openaire   +2 more sources

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2 [PDF]

, 2002
Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved.
Zhang, S., Wen, G., Minichiello, L., Zhang, Si Qing, Wen, Gengyun, Araki, T., Klein, R., Tsiaras, B., Neel, Benjamin G, Neel, B., Araki, Toshiyuki, Klein, Ruediger, Minichiello, Liliana, Tsiaras, William G   +13 more
core   +1 more source