Results 11 to 20 of about 1,444,803 (306)
PPP1R2 stimulates protein phosphatase-1 through stabilisation of dynamic subunit interactions [PDF]
Nature CommunicationsProtein Ser/Thr phosphatase PP1 is always associated with one or two regulatory subunits or RIPPOs. One of the earliest evolved RIPPOs is PPP1R2, also known as Inhibitor-2.
Sarah Lemaire +11 more
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The Multifaceted Role of Protein Phosphatase 1 in Plasmodium [PDF]
Trends in Parasitology, 2021 Protein phosphatase type 1 (PP1) forms a wide range of Ser/Thr-specific phosphatase holoenzymes which contain one catalytic subunit (PP1c), present in all eukaryotic cells, associated with variable subunits known as regulatory proteins. It has recently been shown that regulators take a leading role in the organization and the control of PP1 functions ...
Khalife, Jamal +3 more
openaire +4 more sources
Regulation of protein phosphatase-1 [PDF]
Chemistry & Biology, 2000 Reversible protein phosphorylation is a major regulatory mechanism of intracellular signal transduction. Protein phosphatase 1 (PP1) is one of four major types of serine-threonine phosphatases mediating signaling pathways, but the means by which its activity is modulated has only recently begun to come into focus.
Aggen, James B +2 more
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Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. [PDF]
PLoS ONE, 2012 Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. We previously identified PFN1 as a huntingtin aggregation inhibitor, and others have implicated it as a ...
Jieya Shao, Marc I Diamond
doaj +1 more source
Frontiers in Immunology, 2021 CREB binding protein (CBP), a transcriptional coactivator and acetyltransferase, is involved in the pathogenesis of inflammation-related diseases. High mobility group box-1 protein (HMGB1) is a critical mediator of lethal sepsis, which has prompted ...
Xiaowen Bi +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Human cytomegalovirus (HCMV) carries the human protein phosphatase 1 (PP1) and other human proteins important for protein translation in its tegument layer for a rapid supply upon infection.
Carmen Stecher +8 more
doaj +1 more source
Determinants of the nucleolar targeting of protein phosphatase‐1 [PDF]
FEBS Letters, 2005 The ubiquitously expressed protein Ser/Thr phosphatase‐1 isoforms PP1α, PP1β and PP1γ1 are dynamically targeted to distinct, but overlapping cellular compartments by associated proteins. Within the nucleus of HeLa cells, EGFP‐tagged PP1γ1 and PP1β were predominantly targeted to the nucleoli, while PP1α showed a more diffuse distribution.
Lesage, Bart +4 more
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Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. [PDF]
PLoS ONE, 2011 The cyclin-dependent kinase CDK9/cyclin T1 induces HIV-1 transcription by phosphorylating the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII).
Tatiana Ammosova +7 more
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Heparin inhibits the activity of protein phosphatase‐1 [PDF]
FEBS Letters, 1984 Heparin inhibited the dephosphorylation of rabbit skeletal muscle or liver phosphorylase a by protein phosphatase‐1. Other glycosaminoglycans (chondroitin sulfates) and their constituents were found to be without effect. The chromatography of a partially purified phosphatase preparation on heparin—Sepharose CL‐6B resulted in a fraction that did not ...
Gergely, Pál +2 more
openaire +2 more sources
The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. [PDF]
PLoS ONE, 2013 Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter.
Mariana Santos +7 more
doaj +1 more source