Loss of protein phosphatase 1 regulator TIMAP protein triggers EMT in A549 cells [PDF]
Cell Communication and SignalingBackground Epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that enables epithelial cells to acquire mesenchymal traits, leading to enhanced motility, invasiveness, and resistance to therapy.
Fanni Szalmás +3 more
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Mapping the Protein Phosphatase 1 Interactome in Human Cytomegalovirus Infection [PDF]
VirusesProtein phosphorylation is a crucial regulatory mechanism in cellular homeostasis. The human cytomegalovirus (HCMV) incorporates protein phosphatase 1 (PP1) into its tegument, yet the biological relevance and mechanisms of this incorporation remain ...
Stefan Weinberger +4 more
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Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission [PDF]
Frontiers in Synaptic Neuroscience, 2022 Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory.
Karl Foley +15 more
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Protein Phosphatase-1 Regulates Expression of Neuregulin-1 [PDF]
Biology, 2016 Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova +7 more
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PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis [PDF]
Biomolecules, 2023 Raf-1, a multifunctional kinase, regulates various cellular processes, including cell proliferation, apoptosis, and migration, by phosphorylating MAPK/ERK kinase and interacting with specific kinases.
Jason A. Kirkbride +7 more
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Modulation of dendritic spines by protein phosphatase-1. [PDF]
Adv Pharmacol, 2021 Protein phosphatase-1 (PP-1), a highly conserved multifunctional serine/threonine phosphatase, is enriched in dendritic spines where it plays a major role in modulating excitatory synaptic activity. In addition to established functions in spine maturation and development, multi-subunit holoenzyme forms of PP-1 modulate higher-order cognitive functions ...
Platholi J, Hemmings HC.
europepmc +3 more sources
Protein Phosphatase 1 Regulatory Subunit 3: A Prognostic Biomarker in Stomach Adenocarcinoma [PDF]
International Journal of General Medicine, 2022 Ya-Zhen Zhu,1 Xi-Wen Liao,2 Wu Yin,1 Hai-Ming Wei1 1Department of Pathology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People’s Republic of China; 2Department of Hepatobiliary Surgery, The First Affiliated Hospital of ...
Zhu YZ, Liao XW, Yin W, Wei HM
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PPP1R2 stimulates protein phosphatase-1 through stabilisation of dynamic subunit interactions [PDF]
Nature CommunicationsProtein Ser/Thr phosphatase PP1 is always associated with one or two regulatory subunits or RIPPOs. One of the earliest evolved RIPPOs is PPP1R2, also known as Inhibitor-2.
Sarah Lemaire +11 more
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The Multifaceted Role of Protein Phosphatase 1 in Plasmodium [PDF]
Trends in Parasitology, 2021 Protein phosphatase type 1 (PP1) forms a wide range of Ser/Thr-specific phosphatase holoenzymes which contain one catalytic subunit (PP1c), present in all eukaryotic cells, associated with variable subunits known as regulatory proteins. It has recently been shown that regulators take a leading role in the organization and the control of PP1 functions ...
Khalife, Jamal +3 more
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Regulation of protein phosphatase-1 [PDF]
Chemistry & Biology, 2000 Reversible protein phosphorylation is a major regulatory mechanism of intracellular signal transduction. Protein phosphatase 1 (PP1) is one of four major types of serine-threonine phosphatases mediating signaling pathways, but the means by which its activity is modulated has only recently begun to come into focus.
Aggen, James B +2 more
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