Results 21 to 30 of about 1,442,861 (307)

Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. [PDF]

PLoS ONE, 2012
Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. We previously identified PFN1 as a huntingtin aggregation inhibitor, and others have implicated it as a ...
Jieya Shao, Marc I Diamond
doaj   +1 more source

CBP Bromodomain Inhibition Rescues Mice From Lethal Sepsis Through Blocking HMGB1-Mediated Inflammatory Responses

Frontiers in Immunology, 2021
CREB binding protein (CBP), a transcriptional coactivator and acetyltransferase, is involved in the pathogenesis of inflammation-related diseases. High mobility group box-1 protein (HMGB1) is a critical mediator of lethal sepsis, which has prompted ...
Xiaowen Bi, Baolin Jiang, Jinyi Zhou, Xirui Fan, Xintong Yan, Juanjuan Liang, Lan Luo, Zhimin Yin   +7 more
doaj   +1 more source

Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling

Frontiers in Microbiology, 2021
Human cytomegalovirus (HCMV) carries the human protein phosphatase 1 (PP1) and other human proteins important for protein translation in its tegument layer for a rapid supply upon infection.
Carmen Stecher, Sanja Marinkov, Lucia Mayr-Harting, Ana Katic, Marie-Theres Kastner, Franz J. J. Rieder-Rommer, Xionghao Lin, Sergei Nekhai, Christoph Steininger   +8 more
doaj   +1 more source

Determinants of the nucleolar targeting of protein phosphatase‐1 [PDF]

FEBS Letters, 2005
The ubiquitously expressed protein Ser/Thr phosphatase‐1 isoforms PP1α, PP1β and PP1γ1 are dynamically targeted to distinct, but overlapping cellular compartments by associated proteins. Within the nucleus of HeLa cells, EGFP‐tagged PP1γ1 and PP1β were predominantly targeted to the nucleoli, while PP1α showed a more diffuse distribution.
Lesage, Bart, Beullens, Monique, Ceulemans, Hugo, Himpens, Bernard, Bollen, Mathieu   +4 more
openaire   +2 more sources

Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. [PDF]

PLoS ONE, 2011
The cyclin-dependent kinase CDK9/cyclin T1 induces HIV-1 transcription by phosphorylating the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII).
Tatiana Ammosova, Yuri Obukhov, Alexander Kotelkin, Denitra Breuer, Monique Beullens, Victor R Gordeuk, Mathieu Bollen, Sergei Nekhai   +7 more
doaj   +1 more source

Heparin inhibits the activity of protein phosphatase‐1 [PDF]

FEBS Letters, 1984
Heparin inhibited the dephosphorylation of rabbit skeletal muscle or liver phosphorylase a by protein phosphatase‐1. Other glycosaminoglycans (chondroitin sulfates) and their constituents were found to be without effect. The chromatography of a partially purified phosphatase preparation on heparin—Sepharose CL‐6B resulted in a fraction that did not ...
Gergely, Pál, Erd'́odi, Ferenc, Bot, György   +2 more
openaire   +2 more sources

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. [PDF]

PLoS ONE, 2013
Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter.
Mariana Santos, Sandra Rebelo, Paula J M Van Kleeff, Connie E Kim, William T Dauer, Margarida Fardilha, Odete A da Cruz E Silva, Edgar F da Cruz E Silva   +7 more
doaj   +1 more source

The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains [PDF]

, 2007
Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid, Brenchley Rachel, Matthews Keith, Balázs Szöőr, Stevens Robert, Tabernero, Lydia, McElhinney Helen, Tabernero, Lydia; id_orcid, McElhinney, Helen, Huxley-Jones, Julie, Julie Huxley-Jones, Brenchley, Rachel, Tariq, Humera, Helen McElhinney, Tariq Humera, Keith Matthews, Matthews, Keith; id_orcid, Rachel Brenchley, Szöőr Balázs, Robert Stevens, Tabernero Lydia, Szöor, Balázs, Humera Tariq, Lydia Tabernero, Huxley-Jones Julie, Stevens, Robert, Matthews, Keith   +26 more
core   +1 more source

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Journal of Lipid Research, 2004
The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant, Zdzislaw Szulc, Patrick Roddy, Alicja Bielawska, Yusuf A. Hannun   +4 more
doaj   +1 more source

Regulation of protein phosphatase 1 by intrinsically disordered proteins [PDF]

Biochemical Society Transactions, 2012
PP1 (protein phosphatase 1) is an essential serine/threonine phosphatase that plays a critical role in a broad range of biological processes, from muscle contraction to memory formation. PP1 achieves its biological specificity by forming holoenzymes with more than 200 known regulatory proteins.
Meng S, Choy, Rebecca, Page, Wolfgang, Peti   +2 more
openaire   +2 more sources