Results 41 to 50 of about 2,399,730 (304)

Protein phosphatase-1: dual activity regulation by Inhibitor-2

Biochemical Society Transactions, 2020
Inhibitor-2 (I2) ranks amongst the most ancient regulators of protein phosphatase-1 (PP1). It is a small, intrinsically disordered protein that was originally discovered as a potent inhibitor of PP1. However, later investigations also characterized I2 as an activator of PP1 as well as a chaperone for PP1 folding.
Lemaire, Sarah, Bollen, Mathieu
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In vivo actions of protein phosphatase inhibitor‐2 inXenopusoocytes [PDF]

FEBS Letters, 1982
Meiotic maturation of amphibian oocytes induced by progesterone is known to be regulated by protein phosphorylation. To investigate a possible role for protein phosphatase‐1 in this process, the effect of phosphatase inhibitor‐2 was determined on the in vivo rate of dephosphorylation of phosphorylaseaand on the rate of oocyte maturation ...
Foulkes, J.Gordon, Maller, James L.
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Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis [PDF]

Journal of Signal Transduction, 2011
SHP-2 (PTPN11), a ubiquitously expressed protein tyrosine phosphatase, is critical for hematopoietic cell development and function owing to its essential role in growth factor/cytokine signaling. More importantly, germline and somatic mutations in this phosphatase are associated with Noonan syndrome, Leopard syndrome, and childhood hematologic ...
Liu, Xia, Qu, Cheng-Kui
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cis-2 and trans-2-eicosenoic Fatty Acids Inhibit Mycobacterium tuberculosis Virulence Factor Protein Tyrosine Phosphatase B

Journal of the Turkish Chemical Society, Section A: Chemistry, 2021
The present study aims to investigate the potential inhibitory effect of eicosenoic fatty acids on protein tyrosine phosphatase B of Mycobacterium tuberculosis (PtpB). PtpB is recognized to play a vital role in Mycobacterium tuberculosis (Mtb) successful
Lalu Rudyat Telly SAVALAS, Asih LESTARİ, Munirah MUNİRAH, Suryawati FARİDA, Dedy SUHENDRA, Dina ASNAWATİ , Jannatin 'ARDHUHA, Baiq SARI NİNGSİH, Jufrizal SYAHRİ   +8 more
doaj   +1 more source

Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies

Acta Pharmaceutica Sinica B, 2020
Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy target for various diseases, serving as a well-known oncogenic phosphatase in cancers.
Zhendong Song, Meijing Wang, Yang Ge, Xue-Ping Chen, Ziyang Xu, Yang Sun, Xiao-Feng Xiong   +6 more
semanticscholar   +1 more source

Protein phosphatase 1α is a Ras‐activated Bad phosphatase that regulates interleukin‐2 deprivation‐induced apoptosis [PDF]

The EMBO Journal, 2000
Growth factor deprivation is a physiological mechanism to regulate cell death. We utilize an interleukin-2 (IL-2)-dependent murine T-cell line to identify proteins that interact with Bad upon IL-2 stimulation or deprivation. Using the yeast two-hybrid system, glutathione S-transferase (GST) fusion proteins and co-immunoprecipitation techniques, we ...
Ayllon, V., Martinez, C., Garcia, Alphonse, Cayla, Xavier, Rebollo, A.   +4 more
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A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) [PDF]

Scientific Reports, 2015
AbstractProtein tyrosine phosphatases (PTPs) are involved in numerous signaling pathways and dysfunctions of certain of these enzymes have been linked to several human diseases including cancer and autoimmune diseases. PTPN2 is a PTP mainly expressed in hematopoietic cells and involved in growth factor and JAK/STAT signaling pathways.
Duval, Romain, Bui, Linh-Chi, Berthelet, Jérémy, Dairou, Julien, Mathieu, Cécile, Guidez, Fabien, Dupret, Jean-Marie, Cools, Jan, Chomienne, Christine, Rodrigues-Lima, Fernando   +9 more
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Protein tyrosine phosphatase non-receptor type 2 as the therapeutic target of atherosclerotic diseases: past, present and future

Frontiers in Pharmacology, 2023
Tyrosine-protein phosphatase non-receptor type 2(PTPN2), an important member of the protein tyrosine phosphatase family, can regulate various signaling pathways and biological processes by dephosphorylating receptor protein tyrosine kinases. Accumulating
Xiao-Er Tang, Ya-Qiong Cheng, Chao-Ke Tang   +2 more
doaj   +1 more source

Inhibitors of Src Homology-2 Domain containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Journal of Medicinal Chemistry, 2008
Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-117199) which inhibits the protein tyrosine phosphatase (PTPa) Shp2 with an IC50 of 47 μM.
H. Lawrence, Roberta Pireddu, Liwei Chen, Yunting Luo, S. Sung, A. Szymanski, M. Yip, W. Guida, S. Sebti, Jie Wu, N. Lawrence   +10 more
semanticscholar   +1 more source

Discordance between the Binding Affinity of Mitogen-activated Protein Kinase Subfamily Members for MAP Kinase Phosphatase-2 and Their Ability to Activate the Phosphatase Catalytically*

Journal of Biological Chemistry, 2001
MKP-2 is a member of the mitogen-activated protein (MAP) kinase phosphatase family which has been suggested to play an important role in the feedback control of MAP kinase-mediated gene expression.
Peili Chen, D. Hutter, Xiaoling Yang, M. Gorospe, R. Davis, Yusen Liu   +5 more
semanticscholar   +1 more source