Results 41 to 50 of about 625,556 (313)

In vivo actions of protein phosphatase inhibitor‐2 inXenopusoocytes [PDF]

FEBS Letters, 1982
Meiotic maturation of amphibian oocytes induced by progesterone is known to be regulated by protein phosphorylation. To investigate a possible role for protein phosphatase‐1 in this process, the effect of phosphatase inhibitor‐2 was determined on the in vivo rate of dephosphorylation of phosphorylaseaand on the rate of oocyte maturation ...
Foulkes, J.Gordon, Maller, James L.
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The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]

, 2007
Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
core   +1 more source

Protein phosphatase-1: dual activity regulation by Inhibitor-2

Biochemical Society Transactions, 2020
Inhibitor-2 (I2) ranks amongst the most ancient regulators of protein phosphatase-1 (PP1). It is a small, intrinsically disordered protein that was originally discovered as a potent inhibitor of PP1. However, later investigations also characterized I2 as an activator of PP1 as well as a chaperone for PP1 folding.
Lemaire, Sarah, Bollen, Mathieu
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Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis [PDF]

Journal of Signal Transduction, 2011
SHP-2 (PTPN11), a ubiquitously expressed protein tyrosine phosphatase, is critical for hematopoietic cell development and function owing to its essential role in growth factor/cytokine signaling. More importantly, germline and somatic mutations in this phosphatase are associated with Noonan syndrome, Leopard syndrome, and childhood hematologic ...
Liu, Xia, Qu, Cheng-Kui
openaire   +2 more sources

cis-2 and trans-2-eicosenoic Fatty Acids Inhibit Mycobacterium tuberculosis Virulence Factor Protein Tyrosine Phosphatase B

Journal of the Turkish Chemical Society, Section A: Chemistry, 2021
The present study aims to investigate the potential inhibitory effect of eicosenoic fatty acids on protein tyrosine phosphatase B of Mycobacterium tuberculosis (PtpB). PtpB is recognized to play a vital role in Mycobacterium tuberculosis (Mtb) successful
Lalu Rudyat Telly SAVALAS, Asih LESTARİ, Munirah MUNİRAH, Suryawati FARİDA, Dedy SUHENDRA, Dina ASNAWATİ , Jannatin 'ARDHUHA, Baiq SARI NİNGSİH, Jufrizal SYAHRİ   +8 more
doaj   +1 more source

A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) [PDF]

Scientific Reports, 2015
AbstractProtein tyrosine phosphatases (PTPs) are involved in numerous signaling pathways and dysfunctions of certain of these enzymes have been linked to several human diseases including cancer and autoimmune diseases. PTPN2 is a PTP mainly expressed in hematopoietic cells and involved in growth factor and JAK/STAT signaling pathways.
Duval, Romain, Bui, Linh-Chi, Berthelet, Jérémy, Dairou, Julien, Mathieu, Cécile, Guidez, Fabien, Dupret, Jean-Marie, Cools, Jan, Chomienne, Christine, Rodrigues-Lima, Fernando   +9 more
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MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana

, 2010
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
Juliane Schroeder, Plevin Robin, Kurnik Magdalena, H. Adrienne McGachy, Shweash, M.S., Cadalbert Laurence C., H Adrienne McGachy, Callum M Sloss, James Alexander, Shweash Muhannad, Bryant, C.E., Laurence C Cadalbert, Cadalbert, L.C., Clare E Bryant, Laurence C. Cadalbert, Alexander, James, Mashael S Al-Mutairi, Muhannad Shweash, Al-Mutairi Mashael S., Al-Mutairi, M.S., Schroeder Juliane, Callum M. Sloss, Alexander James, Robin Plevin, Sloss Callum M., Schroeder, J., Plevin, R.J., Sloss, C.M., Mashael S. Al-Mutairi, McGachy, H.A., Clare E. Bryant, McGachy H. Adrienne, Bryant Clare E., Magdalena Kurnik, Kurnik, M.   +34 more
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Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task [PDF]

, 2006
The regulation and function of the calcium-dependent phosphatase calcineurin (CaN, protein phosphatase 2B) in learning and memory remain unclear, although recent work indicates that CaN may play a differential role in training and reversal training.
Havekes, Robbert,, Luiten, Paul G. M., Havekes, Robbert, Nijholt, Ingrid M.,, van der Zee, Eddy A., Havekes, Robbert; id_orcid, Nijholt, Ingrid M., Luiten, Paul G.M.,, Zee, Eddy A. van der,   +8 more
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PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Review on PPP2R1A, with data on DNA, on the protein encoded, and where the gene is implicated.
Sultana, Razia, Nakayama, Kentaro, Nakamura, Kohei, Kyo, Satoru   +3 more
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Protein tyrosine phosphatase non-receptor type 2 as the therapeutic target of atherosclerotic diseases: past, present and future

Frontiers in Pharmacology, 2023
Tyrosine-protein phosphatase non-receptor type 2(PTPN2), an important member of the protein tyrosine phosphatase family, can regulate various signaling pathways and biological processes by dephosphorylating receptor protein tyrosine kinases. Accumulating
Xiao-Er Tang, Ya-Qiong Cheng, Chao-Ke Tang   +2 more
doaj   +1 more source