Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily [PDF]
, 2008 Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination.
Bahri, Sami +3 more
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Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is a chronic articular disease characterized by cartilage degradation, subchondral bone remodeling and osteophyte formation. Src homology 2 domain-containing protein tyrosine phosphatase (SHP2) has not been fully investigated in the ...
Tenghui Tao +10 more
doaj +1 more source
Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair [PDF]
, 2012 Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase ...
Alexandra K. Walker +41 more
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H2O2 Inhibits ABA-Signaling Protein Phosphatase HAB1
PLoS ONE, 2014 Due to its ability to be rapidly generated and propagated over long distances, H2O2 is an important second messenger for biotic and abiotic stress signaling in plants. In response to low water potential and high salt concentrations sensed in the roots of plants, the stress hormone abscisic acid (ABA) activates NADPH oxidase to generate H2O2, which is ...
Sridharamurthy M. +6 more
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A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart. [PDF]
, 2017 Phospholamban (PLN) is a key regulator of sarcolemma calcium uptake in cardiomyocyte, its inhibitory activity to SERCA is regulated by phosphorylation. PLN hypophosphorylation is a common molecular feature in failing heart.
Akaike, Toru +5 more
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Phosphotyrosyl-protein phosphatase of TCRC-2 cells.
Journal of Biological Chemistry, 1982 Homogenization of TCRC-2 cells yielded a phosphotyrosyl-protein phosphatase with a specific activity approximately 10-=fold higher in particulate than in soluble fractions. Over 90% of the phosphotyrosyl-protein phosphatase associated with the particles was solubilized with 1.0% Nonidet P-40.
G, Swarup +3 more
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PPP2R1A (protein phosphatase 2 regulatory subunit A, alpha) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Review on PPP2R1A, with data on DNA, on the protein encoded, and where the gene is implicated.
Sultana, Razia +3 more
openaire +2 more sources
Endogenous inhibitor proteins that connect Ser/Thr kinases and phosphatases in cell signaling. [PDF]
, 2012 Protein phosphatase activity acts as a primary determinant of the extent and duration of phosphorylation of cellular proteins in response to physiological stimuli. Ser/Thr protein phosphatase-1 (PP1) belongs to the PPP superfamily, and is associated with
Brautigan, David L, Eto, Masumi
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Journal of the Turkish Chemical Society, Section A: Chemistry, 2021 The present study aims to investigate the potential inhibitory effect of eicosenoic fatty acids on protein tyrosine phosphatase B of Mycobacterium tuberculosis (PtpB). PtpB is recognized to play a vital role in Mycobacterium tuberculosis (Mtb) successful
Lalu Rudyat Telly SAVALAS +8 more
doaj +1 more source
Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. [PDF]
, 2016 Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-
Brown, Powel H +13 more
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