Results 71 to 80 of about 625,556 (313)

MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]

, 2007
Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Timm Schroeder, Stefan Zahler, Eilken, H.M., Bubik, M.F., Vollmar, Angelika M., Alexandra K. Kiemer, Kiemer, Alexandra K., Zahler, S., Fürst, Robert, Robert Fürst, Schroeder, Timm, Martin F. Bubik, Angelika M. Vollmar, Hanna M. Eilken, Vollmar, A.M., Eilken, Hanna M., Fürst, R., Bubik, Martin F., Zahler, Stefan, Schroeder, T., Kiemer, A.K.   +20 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
Aims/HypothesisReduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt ...
Hage Hassan, Rima, Hundal, Harinder S, Gray, Alexander; id_orcid, Lipina Christopher, Hundal, Harinder S., Alexander Gray, Hajduch, Eric, Rima Hage Hassan, David Magill, Eric Hajduch, Hage Hassan Rima, Nardi, Francesca, Francesca Nardi, Hajduch Eric, Magill David, Gray, Alexander, Hundal Harinder S., Lipina, Christopher, Nardi Francesca, Harinder S Hundal, Magill, David, Christopher Lipina, Gray Alexander   +22 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Protein Kinases and Phosphatases of the Plastid and Their Potential Role in Starch Metabolism

Frontiers in Plant Science, 2018
Phospho-proteomic studies have confirmed that phosphorylation is a common mechanism to regulate protein function in the chloroplast, including the enzymes of starch metabolism.
Chris White-Gloria, Jayde J. Johnson, Kayla Marritt, Amr Kataya, Amr Kataya, Ahmad Vahab, Greg B. Moorhead   +6 more
doaj   +1 more source

Deletion of Protein Tyrosine Phosphatase Nonreceptor Type 2 in Intestinal Epithelial Cells Results in Upregulation of the Related Phosphatase Protein Tyrosine Phosphatase Nonreceptor Type 23 [PDF]

Inflammatory Intestinal Diseases, 2019
<b><i>Background/Aims:</i></b> Knockdown of protein tyrosine phosphatase nonreceptor type 2 (<i>PTPN2</i>) exaggerates IFN-γ-induced intestinal barrier defects, but mice constitutively lacking <i>PTPN2</i> in epithelial cells (PTPN2xVilCre mice) do not show changes in epithelial function or enhanced ...
Ulugöl, Sima, Hering, Larissa, Manzini, Roberto, Montalban Arques, Ana, Gottier, Claudia, Lang, Silvia, Scharl, Michael, Spalinger, Marianne R   +7 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

SHIP2 inhibition alters redox‐induced PI3K/AKT and MAP kinase pathways via PTEN over‐activation in cervical cancer cells

FEBS Open Bio, 2020
Phosphatidylinositol (3,4,5)‐trisphosphate (PI(3,4,5)P3) is required for protein kinase B (AKT) activation. The level of PI(3,4,5)P3 is constantly regulated through balanced synthesis by phosphoinositide 3‐kinase (PI3K) and degradation by ...
Abdelhalim Azzi
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Effects of light and the regulatory Beta subunit composition of protein phosphatase 2A on the susceptibility of Arabidopsis thaliana to aphid (Myzus persicae) infestation

Frontiers in Plant Science, 2014
The interactions between biotic and abiotic stress signalling pathways are complex and poorly understood but protein kinase/phosphatase cascades are potentially important components.
Brwa eRasool, Barbara eKarpinska, Grzegorz eKonert, Guido eDurian, Konstantin eDenessiouk, Saijaliisa eKangasjärvi, Christine Helen Foyer   +6 more
doaj   +1 more source