Results 1 to 10 of about 933,342 (306)

ASPPs multimerize protein phosphatase 1. [PDF]

PLoS Genetics
Protein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown.
Derek T Wei, Kayleigh N Morrison, Gwendolyn M Beacham, Erika Beyrent, Cyrus A Habas, Ying Zhang, Laurence Florens, Gunther Hollopeter   +7 more
doaj   +2 more sources

PTEN protein phosphatase activity regulates metastasis by targeting PKCδ [PDF]

iScience
Summary: PTEN acts as a tumor suppressor through its lipid and protein phosphatase activities. We previously reported that PTEN phosphatase inhibits metastasis independent of its lipid phosphatase.
Yanlin Yu, Ming Zhao, Rand Gabriel M. Buenaventura, Glenn Merlino   +3 more
doaj   +2 more sources

SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release [PDF]

EMBO Reports
The serine/threonine protein phosphatase 5 (PP5) regulates hormone and stress-induced signaling networks. Unlike other phosphoprotein phosphatases, PP5 contains both regulatory and catalytic domains and is further regulated through post-translational ...
Rebecca A Sager, Sarah J Backe, Diana M Dunn, Jennifer A Heritz, Elham Ahanin, Natela Dushukyan, Barry Panaretou, Gennady Bratslavsky, Mark R Woodford, Dimitra Bourboulia, Mehdi Mollapour   +10 more
doaj   +2 more sources

The Plasmodium falciparum Nuclear Protein Phosphatase NIF4 Is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity

mBio, 2022
Artemisinin resistance in Plasmodium falciparum has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant.
Xiaotong Zhu, Siqi Li, Chengqi Wang, Yuanchao Yu, Jingjing Wang, Lu He, Faiza Amber Siddiqui, Lumeng Chen, Liying Zhu, Dan Zhou, Junling Qin, Jun Miao, Liwang Cui, Yaming Cao   +13 more
doaj   +1 more source

Fungal Hal3 (and Its Close Relative Cab3) as Moonlighting Proteins

Journal of Fungi, 2022
Hal3 (Sis2) is a yeast protein that was initially identified as a regulatory subunit of the Saccharomyces cerevisiae Ser/Thr protein phosphatase Ppz1.
Antonio Casamayor, Joaquín Ariño
doaj   +1 more source

Temperature sensing by the calcium-sensing receptor

Frontiers in Physiology, 2023
Whether GPCRs support the sensing of temperature as well as other chemical and physical modalities is not well understood.Introduction: Extracellular Ca2+ concentration (Ca2+o) modulates core body temperature and the firing rates of temperature-sensitive
Sarah C. Brennan, Sarah C. Brennan, Hee-chang Mun, Leigh Delbridge, Philip W. Kuchel, Arthur D. Conigrave, Arthur D. Conigrave   +6 more
doaj   +1 more source

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma

Cells, 2020
Genome integrity is protected by the cell-cycle checkpoints that prevent cell proliferation in the presence of DNA damage and allow time for DNA repair.
Andra S. Martinikova, Monika Burocziova, Miroslav Stoyanov, Libor Macurek   +3 more
doaj   +1 more source

Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development

Frontiers in Genetics, 2022
Almost all cellular activities depend on protein folding, signaling complex assembly/disassembly, and epigenetic regulation. One of the most important regulatory mechanisms responsible for controlling these cellular processes is dynamic protein ...
Jiaen Sun, Jiaen Sun, Minglei Yang, Minglei Yang, Weidi Zhao, Weidi Zhao, Fajiu Wang, Liangwei Yang, Chuntao Tan, Tianjun Hu, Huangkai Zhu, Huangkai Zhu, Guofang Zhao, Guofang Zhao   +13 more
doaj   +1 more source

Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification

Molecular Systems Biology, 2023
Phosphoprotein phosphatases (PPPs) regulate major signaling pathways, but the determinants of phosphatase specificity are poorly understood. This is because methods to investigate this at scale are lacking.
Jamin B Hein, Hieu T Nguyen, Dimitriya H Garvanska, Isha Nasa, Thomas Kruse, Yinnian Feng, Blanca Lopez Mendez, Norman Davey, Arminja N Kettenbach, Polly M Fordyce, Jakob Nilsson   +10 more
doaj   +1 more source

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Journal of Lipid Research, 2004
The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant, Zdzislaw Szulc, Patrick Roddy, Alicja Bielawska, Yusuf A. Hannun   +4 more
doaj   +1 more source