Results 21 to 30 of about 933,342 (306)

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway [PDF]

, 2012
Protein phosphatases play a key role in balancing the cellular responses to the transforming growth factor-beta (TGF beta) signals. Several protein phosphatases have been attributed roles in the regulation of the TGF beta pathway. Among these.
Bruce, David L., Macartney, Thomas, Sapkota, Gopal P., Shou, Weinian, Yong, Weidong   +4 more
core   +3 more sources

Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

Cellular Physiology and Biochemistry, 2013
Background/Aims: The linoleic acid derivative DCP-LA selectively activates PKCε and inhibits protein phosphatase 1 (PP1). In the present study, we have newly synthesized phosphatidyl-ethanolamine, -serine, -choline, and -inositol containing DCP-LA at the
Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Tomoyuki Nishizaki   +5 more
doaj   +1 more source

PTEN: A master regulator of neuronal structure, function, and plasticity. [PDF]

, 2014
PTEN (phosphatase and tensin homolog on chromosome ten) is a dual protein/lipid phosphatase that dephosphorylates PIP3, thereby inhibiting the AKT/mTOR pathway. This inhibition ultimately decreases protein translation, cell proliferation and cell growth.
Garcia-Junco-Clemente, Pablo, Golshani, Peyman   +1 more
core   +1 more source

Research Trends in C-Terminal Domain Nuclear Envelope Phosphatase 1

Life, 2023
C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly Dullard) is a member of the newly emerging protein phosphatases and has been recognized in neuronal cell tissues in amphibians.
Harikrishna Reddy Rallabandi, Haewon Choi, Hyunseung Cha, Young Jun Kim   +3 more
doaj   +1 more source

A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients [PDF]

, 2017
Background: Protein tyrosine phosphatase receptor gamma (PTPRG) is a ubiquitously expressed member of the protein tyrosine phosphatase family known to act as a tumor suppressor gene in many different neoplasms with mechanisms of inactivation including ...
Al Sayab, Ali, Al-Dewik, Nader, Fiorini, Zeno, Holyoake, Tessa L., Ismail, Mohamed A., Krampera, Mauro, Lorenzetto, Erika, Mafficini, Andrea, Monne, Maria, Moratti, Elisabetta, Pellicano, Francesca, Sorio, Claudio, Tecchio, Cristina, Tomasello, Luisa, Vezzalini, Marzia, Yassin, Mohamed   +15 more
core   +3 more sources

The Emerging Role of Protein Phosphatase in Regeneration

Life, 2023
Maintaining normal cellular behavior is essential for the survival of organisms. One of the main mechanisms to control cellular behavior is protein phosphorylation.
Meiling Zhang, Chenglin Liu, Long Zhao, Xuejiao Zhang, Ying Su   +4 more
doaj   +1 more source

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. [PDF]

, 2018
Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors ...
Beckendorf, Lisa, Boknik, Peter, Dos Remedios, Cris G, Gergs, Ulrich, Hamdani, Nazha, Krysiak, Judith, Linke, Wolfgang A, Redfield, Margaret M, Sheikh, Farah, Unger, Andreas, von Frieling-Salewsky, Marion   +10 more
core   +3 more sources

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

eLife, 2019
Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors.
Kerryn Berndsen, Pawel Lis, Wondwossen M Yeshaw, Paulina S Wawro, Raja S Nirujogi, Melanie Wightman, Thomas Macartney, Mark Dorward, Axel Knebel, Francesca Tonelli, Suzanne R Pfeffer, Dario R Alessi   +11 more
doaj   +1 more source

The Mitogen-Activated Protein Kinase Slt2 Promotes Asymmetric Cell Cycle Arrest and Reduces TORC1-Sch9 Signaling in Yeast Lacking the Protein Phosphatase Ptc1

Microbiology Spectrum, 2023
Mitogen-activated protein kinase (MAPK) pathways regulate essential processes in eukaryotes. However, since uncontrolled activation of these cascades has deleterious effects, precise negative regulation of signaling flow through them, mainly executed by ...
Gema González-Rubio, Humberto Martín, María Molina   +2 more
doaj   +1 more source

A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

eLife, 2020
The recruitment of substrates by the ser/thr protein phosphatase 2A (PP2A) is poorly understood, limiting our understanding of PP2A-regulated signaling. Recently, the first PP2A:B56 consensus binding motif, LxxIxE, was identified. However, most validated
Xinru Wang, Dimitriya H Garvanska, Isha Nasa, Yumi Ueki, Gang Zhang, Arminja N Kettenbach, Wolfgang Peti, Jakob Nilsson, Rebecca Page   +8 more
doaj   +1 more source