Results 31 to 40 of about 618,514 (262)

H2O2 inhibits ABA-signaling protein phosphatase HAB1. [PDF]

PLoS ONE, 2014
Due to its ability to be rapidly generated and propagated over long distances, H2O2 is an important second messenger for biotic and abiotic stress signaling in plants. In response to low water potential and high salt concentrations sensed in the roots of
Madhuri Sridharamurthy, Amanda Kovach, Yang Zhao, Jian-Kang Zhu, H Eric Xu, Kunchithapadam Swaminathan, Karsten Melcher   +6 more
doaj   +1 more source

Structural Insights into Protein Regulation by Phosphorylation and Substrate Recognition of Protein Kinases/Phosphatases

Life, 2021
Protein phosphorylation is one of the most widely observed and important post-translational modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each of which covalently attaches a phosphate group to an amino acid side ...
Seung-Hyeon Seok
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest

eLife
Virion Infectivity Factor (Vif) of the Human Immunodeficiency Virus type 1 (HIV-1) targets and degrades cellular APOBEC3 proteins, key regulators of intrinsic and innate antiretroviral immune responses, thereby facilitating HIV-1 infection.
Dhaval Ghone, Edward L Evans, Madison Bandini, Kaelyn G Stephenson, Nathan M Sherer, Aussie Suzuki   +5 more
doaj   +1 more source

Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation.

PLoS ONE, 2013
In human and experimental heart failure, the activity of the type 1 phosphatase is significantly increased, associated with dephosphorylation of phospholamban, inhibition of the sarco(endo)plasmic reticulum Ca(2+) transport ATPase (SERCA2a) and depressed
Elizabeth Vafiadaki, Demetrios A Arvanitis, Despina Sanoudou, Evangelia G Kranias   +3 more
doaj   +1 more source

Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure‐Overloaded Hearts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Insulin resistance in diabetes mellitus has been associated with mitochondrial dysfunction. Defects at the level of mitochondria are also characteristic of heart failure.
T. Dung Nguyen, Michael Schwarzer, Andrea Schrepper, Paulo A. Amorim, Daniel Blum, Claudia Hain, Gloria Faerber, Judith Haendeler, Joachim Altschmied, Torsten Doenst   +9 more
doaj   +1 more source

STABILITY AND CATALYTIC EFFICIENCY OF THE ENZYMES IMMOBILIZED ON NATURAL AND SYNTHETIC ORGANO-CLAY COMPLEXES [PDF]

Journal of Soil Sciences and Agricultural Engineering, 2008
This investigation was conducted on soil samples collected from different fluvial and lacustrine depositional environments, irrigated for a long-time with either Nile water or wastewaters.
M.A.M. El-Kammah
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Phosphorylation of Plant Microtubule-Associated Proteins During Cell Division

Frontiers in Plant Science, 2019
Progression of mitosis and cytokinesis depends on the reorganization of cytoskeleton, with microtubules driving the segregation of chromosomes and their partitioning to two daughter cells.
Tereza Vavrdová, Jozef ˇSamaj, George Komis   +2 more
doaj   +1 more source