Results 1 to 10 of about 1,396,343 (168)
An optimized protocol for acquiring and processing cryo-EM data of human 26S proteasome with M1-Ub6
STAR Protocols, 2021 Summary: The 26S proteasome is specialized for regulated protein degradation. It is formed by a regulatory particle (RP) that recognizes ubiquitinated substrates and caps a hollow cylindrical core particle (CP) where substrates are proteolyzed ...
Xiang Chen +3 more
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The Kinase Specificity of Protein Kinase Inhibitor Peptide
Frontiers in Pharmacology, 2021 G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
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Protein Kinase A in Cancer [PDF]
Cancers, 2011 In the past, many chromosomal and genetic alterations have been examined as possible causes of cancer. However, some tumors do not display a clear molecular and/or genetic signature. Therefore, other cellular processes may be involved in carcinogenesis.
CARETTA, Antonio, C. Mucignat Caretta
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Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. [PDF]
PLoS ONE, 2012 Hypoglycemia and neuroglucopenia stimulate AMP-activated protein kinase (AMPK) activity in the hypothalamus and this plays an important role in the counterregulatory responses, i.e.
Junji Kawashima +4 more
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Cells, 2022 Cholangiocarcinoma (CCA) is a lethal malignancy in the hepatobiliary system, with dysregulated protein expression and phosphorylation signaling. However, the protein and phosphorylation signatures of CCAs are little-known.
Yun Lu +6 more
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Frontiers in Pharmacology, 2020 FGIN-1-27 is a synthetic mitochondrial diazepam binding inhibitor receptor (MDR) agonist that has demonstrated pro-apoptotic, anti-anxiety, and steroidogenic activity in various studies.
Jinpeng Lv +6 more
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The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases [PDF]
Journal of Biological Chemistry, 2005 The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to other regulatory signals. AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK kinases (AMPKKs).
Rebecca L, Hurley +5 more
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A-kinase-anchoring proteins [PDF]
Journal of Cell Science, 2004 Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation ([Pawson and Nash, 2003][1]). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-
Lorene K, Langeberg, John D, Scott
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Physiological Phosphorylation of Protein Kinase A at Thr-197 Is by a Protein Kinase A Kinase [PDF]
Molecular and Cellular Biology, 1998 Phosphorylation of the catalytic subunit of cyclic AMP-dependent protein kinase, or protein kinase A, on Thr-197 is required for optimal enzyme activity, and enzyme isolated from either animal sources or bacterial expression strains is found phosphorylated at this site.
R D, Cauthron +3 more
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Protein Kinases in Leukemias [PDF]
Cancers, 2021 Protein kinases (PK) make up around 2% of the human genome and their expression profile varies depending on the organ and tissue [...]
Paulo De Sepulveda, Jean-Max Pasquet
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