Results 11 to 20 of about 4,965,955 (309)
Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation [PDF]
, 2014 Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis.
Schmid, Ralf +8 more
core +3 more sources
Chemical genetic identification of GAK substrates reveals its role in regulating Na + /K + -ATPase
Life Science Alliance, 2018 Novel GAK phosphorylation targets are identified using chemical genetic methods. One of the substrates is the α subunit of the Na + /K + -ATPase, phosphorylation of which is necessary for its surface trafficking from endosomes. Conserved functions of NAK
Amy W Lin +9 more
doaj +1 more source
Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]
, 2007 Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P. +3 more
core +1 more source
Cell Reports, 2016 In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in lethality at ...
Ivan Quétier +17 more
doaj +1 more source
Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism
Molecular Metabolism, 2022 Objective: The liver is the primary internal metabolic organ that coordinates whole body energy homeostasis in response to feeding and fasting. Genetic ablation or pharmacological inhibition of calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2)
Brittany A. Stork +15 more
doaj +1 more source
Metabolic Kinases Moonlighting as Protein Kinases [PDF]
Trends in Biochemical Sciences, 2018 Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and ...
Zhimin, Lu, Tony, Hunter
openaire +2 more sources
Mitochondrial protein import under kinase surveillance
Microbial Cell, 2014 Despite the simplicity of the yeast Saccharomyces cerevisiae,its basic cellular machinery tremendously mirrors that of higher eukaryotic counterparts.
Magdalena Opalińska, Chris Meisinger
doaj +1 more source
Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A
Frontiers in Physiology, 2020 The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival.
Chong Liu +4 more
doaj +1 more source
A-kinase-interacting protein localizes protein kinase A in the nucleus [PDF]
Proceedings of the National Academy of Sciences, 2005 The genetic variability and covalent modifications associated with the amino terminus of the protein kinase A (PKA) catalytic (C) subunit suggest that it may contribute to protein–protein interactions and/or localization. By using a yeast two-hybrid screen, we identified a PKA-interacting protein (AKIP1) that binds to the amino terminus (residues 1–39)
Mira, Sastri +3 more
openaire +2 more sources
Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]
, 2005 Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
core +1 more source