Results 11 to 20 of about 1,357,491 (268)

Protein Kinase A in Cancer [PDF]

Cancers, 2011
In the past, many chromosomal and genetic alterations have been examined as possible causes of cancer. However, some tumors do not display a clear molecular and/or genetic signature. Therefore, other cellular processes may be involved in carcinogenesis.
CARETTA, Antonio, C. Mucignat Caretta
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Metabolic Kinases Moonlighting as Protein Kinases [PDF]

Trends in Biochemical Sciences, 2018
Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and ...
Zhimin, Lu, Tony, Hunter
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Chemical genetic identification of GAK substrates reveals its role in regulating Na + /K + -ATPase

Life Science Alliance, 2018
Novel GAK phosphorylation targets are identified using chemical genetic methods. One of the substrates is the α subunit of the Na + /K + -ATPase, phosphorylation of which is necessary for its surface trafficking from endosomes. Conserved functions of NAK
Amy W Lin, Kalbinder K Gill, Marisol Sampedro Castañeda, Irene Matucci, Noreen Eder, Suzanne Claxton, Helen Flynn, Ambrosius P Snijders, Roger George, Sila K Ultanir   +9 more
doaj   +1 more source

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Cell Reports, 2016
In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in lethality at ...
Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron   +17 more
doaj   +1 more source

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism

Molecular Metabolism, 2022
Objective: The liver is the primary internal metabolic organ that coordinates whole body energy homeostasis in response to feeding and fasting. Genetic ablation or pharmacological inhibition of calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2)
Brittany A. Stork, Adam Dean, Andrea R. Ortiz, Pradip Saha, Nagireddy Putluri, Maricarmen D. Planas-Silva, Iqbal Mahmud, Kimal Rajapakshe, Cristian Coarfa, Stefan Knapp, Philip L. Lorenzi, Bruce E. Kemp, Benjamin E. Turk, John W. Scott, Anthony R. Means, Brian York   +15 more
doaj   +1 more source

A-kinase-interacting protein localizes protein kinase A in the nucleus [PDF]

Proceedings of the National Academy of Sciences, 2005
The genetic variability and covalent modifications associated with the amino terminus of the protein kinase A (PKA) catalytic (C) subunit suggest that it may contribute to protein–protein interactions and/or localization. By using a yeast two-hybrid screen, we identified a PKA-interacting protein (AKIP1) that binds to the amino terminus (residues 1–39)
Mira, Sastri, David M, Barraclough, Peter T, Carmichael, Susan S, Taylor   +3 more
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Mitochondrial protein import under kinase surveillance

Microbial Cell, 2014
Despite the simplicity of the yeast Saccharomyces cerevisiae,its basic cellular machinery tremendously mirrors that of higher eukaryotic counterparts.
Magdalena Opalińska, Chris Meisinger
doaj   +1 more source

Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A

Frontiers in Physiology, 2020
The protein kinase enzyme family plays a pivotal role in almost every aspect of cellular function, including cellular metabolism, division, proliferation, transcription, movement, and survival.
Chong Liu, Ping Ke, Jingjing Zhang, Xiaoying Zhang, Xiongwen Chen   +4 more
doaj   +1 more source

Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A

IUBMB Life, 2023
AbstractAlthough Fischer's extraordinary career came to focus mostly on the protein phosphatases, after his co‐discovery of Phosphorylase Kinase with Ed Krebs he was clearly intrigued not only by cAMP‐dependent protein kinase (PKA), but also by the heat‐stable, high‐affinity protein kinase inhibitor (PKI).
Susan S. Taylor, Friedrich W Herberg, Gianluigi Veglia, Jian Wu   +3 more
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The Tails of Protein Kinase A [PDF]

Molecular Pharmacology, 2022
Protein kinase A (PKA) is a holoenzyme consisting of a regulatory (R)-subunit dimer and two catalytic (C)-subunits. There are two major families of C-subunits, Cα and Cβ, and four functionally nonredundant R-subunits (RIα, RIβ, RIIα, RIIβ). In addition to binding to and being regulated by the R-subunits, the C-subunits are regulated by two tail regions
Susan S, Taylor, Kristoffer, Søberg, Evan, Kobori, Jian, Wu, Sabine, Pautz, Friedrich W, Herberg, Bjørn Steen, Skålhegg   +6 more
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