Results 21 to 30 of about 1,357,491 (268)

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Journal of Lipid Research, 2015
Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which ...
Mini P. Sajan, Robert A. Ivey, Mackenzie C. Lee, Robert V. Farese   +3 more
doaj   +1 more source

Protein Kinases as Drug Development Targets for Heart Disease Therapy

Pharmaceuticals, 2010
Protein kinases are intimately integrated in different signal transduction pathways for the regulation of cardiac function in both health and disease.
Alison L. Müller, Naranjan S. Dhalla
doaj   +1 more source

Human thrombopoiesis depends on Protein kinase Cδ/protein kinase Cε functional couple

Haematologica, 2016
A deeper understanding of the molecular events driving megakaryocytopoiesis and thrombopoiesis is essential to regulate in vitro and in vivo platelet production for clinical applications.
Cecilia Carubbi, Elena Masselli, Silvia Martini, Daniela Galli, Franco Aversa, Prisco Mirandola, Joseph E. Italiano, Giuliana Gobbi, Marco Vitale   +8 more
doaj   +1 more source

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase [PDF]

Journal of Biological Chemistry, 2005
(R)-Roscovitine (CYC202) is often referred to as a "selective inhibitor of cyclin-dependent kinases." Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis.
Bach, S., Knockaert, M., Reinhardt, J., Lozach, O., Schmitt, S., Baratte, B., Koken, M., S. P., Coburn, Tang, L., Jiang, T., D. C., Liang, Galons, H., J. F., Dierick, L. A., Pinna, Meggio, F., Totzke, F., Schachtele, C., Lerman, A. S., Carnero, A., Wan, Y., Gray, N., Meijer, L.   +21 more
openaire   +5 more sources

Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation

Sensors, 2010
The control of vascular smooth muscle contractility enables regulation of blood pressure, which is paramount in physiological adaptation to environmental challenges.
Joseph R. Burgoyne, Philip Eaton
doaj   +1 more source

Protein kinase function of pyruvate kinase M2 and cancer

Cancer Cell International, 2020
Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation.
Xun Chen, Shangwu Chen, Dongsheng Yu
doaj   +1 more source

RESPONSE OF MDR1 AND PDR1 ATP-BINDING CASSETTE-TYPE TRANSPORTER GENES TO BIOTIC SIGNALS IN WHEAT FLAG LEAF TIPS [PDF]

Journal of Plant Development, 2020
ATP-binding cassette-type (ABC) transporters are highly implicated in detoxification processes but not restricted to detoxification processes. Several ABC transporters including wheat Lr34 were shown to function in plant defense responses and secretion ...
Kipkios TUBEI, Lucas CHURCH, Tim XING
doaj   +1 more source

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

Cell Reports, 2022
Summary: In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression.
Elizabeth R. Murray, Shinelle Menezes, Jack C. Henry, Josie L. Williams, Lorena Alba-Castellón, Priththivika Baskaran, Ivan Quétier, Ami Desai, Jacqueline J.T. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward P. Carter, Kairbaan Hodivala-Dilke, Richard P. Grose, Hemant M. Kocher, Nuria Gavara, Oliver Pearce, Pedro Cutillas, John F. Marshall, Angus J.M. Cameron   +26 more
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Protein Kinase C [PDF]

IUBMB Life, 2000
Phosphorylation is a universal language used by cells to relay information between and within cells. One family of kinases that plays a key role in transducing information is the protein kinase C family. Members of this family interpret information from signals that result in phospholipid hydrolysis; they communicate to substrates throughout the cell ...
openaire   +2 more sources

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

eLife, 2020
In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase inhibitor, PKI, which recruits the CRM1/RanGTP nuclear exporting complex.
Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David DT Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia   +13 more
doaj   +1 more source