Results 21 to 30 of about 1,408,289 (218)
The Link between Protein Kinase CK2 and Atypical Kinase Rio1
Pharmaceuticals, 2017 The atypical kinase Rio1 is widespread in many organisms, ranging from Archaebacteria to humans, and is an essential factor in ribosome biogenesis. Little is known about the protein substrates of the enzyme and small-molecule inhibitors of the kinase ...
Konrad Kubiński, Maciej Masłyk
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The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer
Journal of Mind and Medical Sciences, 2020 According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Daniela Miricescu +8 more
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Учёные записки Казанского университета: Серия Естественные науки, 2021 Kinases are important components of many signaling pathways in a cell, and therefore they are involved in the regulation of such diverse processes as transcription, cell cycle progression, apoptosis, cell differentiation, metabolism, and intercellular ...
G.V. Andrianov, I.G. Serebriiskii
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Journal of Pharmacological Sciences, 2007 Angiotensin II (AII) has been reported to induce leukocyte adhesion to endothelium through up-regulation of P-selectin surface expression. However, the underlying molecular and cellular mechanisms remain unknown.
Xiaona Ge, Brad Low, Mei Liang, Jian Fu
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Frontiers in Plant Science, 2022 The ascomycete Colletotrichum gloeosporioides is a causal agent of anthracnose on crops and trees and causes enormous economic losses in the world.
Yu-Ting Pan +6 more
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Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
Tumor Biology, 2017 Raf-kinase inhibitor protein has been reported to inhibit both the Raf/mitogen extracellular signal–regulated kinase/extracellular signal–regulated kinase and nuclear factor kappa-light-chain of activated B cells pathways.
SoHyun Lee +2 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
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Frontiers in Microbiology, 2016 Bacterial protein-tyrosine kinases (BY-kinases) are known to regulate different aspects of bacterial physiology, by phosphorylating cellular protein substrates. Physiological cues that trigger BY-kinases activity are largely unexplored. In Proteobacteria,
Abderahmane Derouiche +3 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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