Results 11 to 20 of about 625,556 (313)

Phosphotyrosyl-protein phosphatase of TCRC-2 cells.

Journal of Biological Chemistry, 1982
Homogenization of TCRC-2 cells yielded a phosphotyrosyl-protein phosphatase with a specific activity approximately 10-=fold higher in particulate than in soluble fractions. Over 90% of the phosphotyrosyl-protein phosphatase associated with the particles was solubilized with 1.0% Nonidet P-40.
G, Swarup, K V, Speeg, S, Cohen, D L, Garbers   +3 more
core   +4 more sources

Bcl-2 Targets Protein Phosphatase 1α to Bad [PDF]

The Journal of Immunology, 2001
Abstract The diverse forms of protein phosphatase 1 (PP1) in vivo result from the association of the catalytic subunit with different regulatory subunits. We recently have described that PP1α is a Ras-activated Bad phosphatase that regulates IL-2 deprivation-induced apoptosis.
Ayllón, Verónica, Cayla, Xavier, García, Alphonse, Roncal, Fernando, Fernández, Raul, Albar, Juan Pablo, Martínez-A., Carlos, Rebollo, Angelita   +7 more
openaire   +4 more sources

Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy.

PLoS ONE, 2021
Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical stress.
Carolina Fernández, Natalia Torrealba, Francisco Altamirano, Valeria Garrido-Moreno, César Vásquez-Trincado, Raúl Flores-Vergara, Camila López-Crisosto, María Paz Ocaranza, Mario Chiong, Zully Pedrozo, Sergio Lavandero   +10 more
doaj   +1 more source

The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains [PDF]

, 2007
Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid, Brenchley Rachel, Matthews Keith, Balázs Szöőr, Stevens Robert, Tabernero, Lydia, McElhinney Helen, Tabernero, Lydia; id_orcid, McElhinney, Helen, Huxley-Jones, Julie, Julie Huxley-Jones, Brenchley, Rachel, Tariq, Humera, Helen McElhinney, Tariq Humera, Keith Matthews, Matthews, Keith; id_orcid, Rachel Brenchley, Szöőr Balázs, Robert Stevens, Tabernero Lydia, Szöor, Balázs, Humera Tariq, Lydia Tabernero, Huxley-Jones Julie, Stevens, Robert, Matthews, Keith   +26 more
core   +1 more source

Scaffold Role of DUSP22 in ASK1-MKK7-JNK Signaling Pathway. [PDF]

PLoS ONE, 2016
Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed cell death.
Anna Ju, Young-Chang Cho, Ba Reum Kim, Sung Goo Park, Jeong-Hoon Kim, Kwonseop Kim, Jaehwi Lee, Byoung Chul Park, Sayeon Cho   +8 more
doaj   +1 more source

Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators

Molecules, 2023
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1), a non-receptor member of the protein tyrosine phosphatase (PTP) family, negatively regulates several signaling pathways that are responsible for pathological cell processes in ...
Huiqing Chen, Zekun Liu, Lixin Gao, Li-Fang Yu, Yubo Zhou, Jie Tang, Jia Li, Fan Yang   +7 more
doaj   +1 more source

PTK2 and PTPN11 expression in myelodysplastic syndromes

Clinics, 2013
OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein ...
Mariana Lazarini, Joao Agostinho Machado-Neto, Leticia Frohlich Archangelo, Bruna Fernandes Mendes-Silva, Carolina Louzao Bigarella, Fabiola Traina, Sara Teresinha Olalla Saad   +6 more
doaj   +1 more source

SH2 domain‐containing protein tyrosine phosphatase‐2 is enriched in eyelid specimens of rosacea

Skin Health and Disease, 2023
Background Rosacea is a cutaneous disease that may secondarily affect the ocular surface. Due to the vision threatening, cosmetic, psychological, and work productivity impact, the identification of cellular targets that govern rosacea would enhance our ...
Apoorv Chebolu, Ramon Bossardi Ramos, Thilaka Arunachalam, Alejandro Pablo Adam, Edward J. Wladis   +4 more
doaj   +1 more source

Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2)

Molecules, 2021
Natural products have continued to offer tremendous opportunities for drug development, as they have long been used in traditional medicinal systems. SHP2 has served as an anticancer target.
Se Jeong Kwon, Dohee Ahn, Hyun-Mo Yang, Hyo Jin Kang, Sang J. Chung   +4 more
doaj   +1 more source

Adipose tissue protein phosphatase inhibitor‐2 [PDF]

European Journal of Biochemistry, 1988
Rat fat cells contain three species of spontaneously active inhibitor proteins of protein phosphatase 1, as resolved by SDS‐PAGE, with apparent molecular masses of 40 kDa, 33 kDa and 28 kDa respectively. The 33‐kDa, thermostable inhibitor was highly purified from bovine adipose tissue and shown to be very similar to inhibitor‐2 of skeletal muscle.
openaire   +2 more sources