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Okadaic acid, a phosphatase inhibitor, decreases macrophage motility
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1991Cellular locomotion results from a series of spatially and temporally integrated reactions. The coordinated regulation of these reactions requires sensitive intracellular signaling mechanisms. Because protein phosphorylation reactions represent important signaling mechanisms in mammalian cells, we investigated the effect of okadaic acid, a ...
A K, Wilson +3 more
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Effects of okadaic acid on mitotic HeLa cells
Journal of Cell Science, 1992ABSTRACT Mitotic HeLa cells were treated with different concentrations of okadaic acid (OA), known to inhibit phosphatase 1 and 2A activities. The cytological effects on the course of mitosis were studied at the light microscopic, immunofluorescence and electron microscopic levels. At the lowest concentration used (1 nM), OA did not show
S, Ghosh, N, Paweletz, D, Schroeter
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Okadaic acid induces apoptosis in Down syndrome fibroblasts
Toxicology in Vitro, 2010Down's syndrome (DS) is characterized by several pathological aspects leading to an increased susceptibility to cardiovascular diseases, infections, leukemia, endocrine alterations. DS patients display some of the physiopathological characteristics of aging, observed also in Alzheimer disease (AD), such as abnormalities in lipids metabolism, diabetes ...
G. Dogliotti +7 more
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Effects of okadaic acid on mouse hemopoietic cells
Biochemical and Biophysical Research Communications, 1989Effects of okadaic acid, a potent non-12-O-tetradecanoyl-phorbol-13-acetate(TPA)-type tumor promoter, on mouse hemopoietic cells were investigated. Okadaic acid stimulated mouse bone marrow cells to form granulocyte-macrophage colony-forming unit (CFU-GM) colonies without added colony stimulating factors(CSFs).
S, Oka +3 more
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Micronucleus induction in mussels exposed to okadaic acid
Toxicon, 2003Some toxins present in the marine environment are capable of inducing mutagenicity and/or carcinogenicity. Among these toxins, okadaic acid (OA) is gaining considerable interest since it induces DNA based modifications at low concentrations and accumulates in filter-feeding marine animals, including those used for human consumption.
C R, Carvalho Pinto-Silva +5 more
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Okadaic Acid, Useful Tool for Studying Cellular Processes
Current Medicinal Chemistry, 2002One of the most interesting groups of substances of marine origin, from structural and pharmacological points of view are polyether toxins, which generally present a great diversity in size and potent biological activities. The subject of this review is limited to okadaic acid (OA).
J J, Fernández +4 more
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Okadaic acid influences thyroid cell proliferation
1996-
LAZZERESCHI, DAVIDE +3 more
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