Results 131 to 140 of about 56,178 (231)

Vaginal Foreign Body Insertion in Adolescents Influenced by Social Media: A Three‐Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Foreign body insertion into the vagina among adolescents, though uncommon, presents unique diagnostic and management challenges. In younger children, diagnosis is often challenging because they may be unable to recall or report foreign body insertion.
Fatemeh Keikha, Huma Homam, Hawraa Hassan Shbeeb, Rana Karimi, Azadeh Tarafdari   +4 more
wiley   +1 more source

Cost-Offsets of New Medications for Treatment of Schizophrenia [PDF]

Broad claims are frequently made that new medications will offset all or part of their costs by reducing other areas of Medicaid spending. In this paper we examine the net impact on spending for new drugs used to treat schizophrenia.
Richard G. Frank, Sharon-Lise Normand, Thomas G. McGuire   +2 more
core  

Wernicke’s Encephalopathy Secondary to Hyperemesis Gravidarum in Pregnancy: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Wernicke's Encephalopathy, although classically associated with chronic alcoholism, can also occur during pregnancy as a complication of hyperemesis gravidarum and is often underdiagnosed. We report a case of a 34‐year‐old pregnant woman at 16 weeks of gestation who presented with prolonged vomiting, altered mental status, nystagmus, and gait ...
Abhishek Mahato, Sameer Parajuli, Bandana Ghimire, Bishal Basnet, Bishal Sigdel, Bishal Kumar Yadav, Sagar Kumar Jha   +6 more
wiley   +1 more source

Profile of olanzapine long-acting injection for the maintenance treatment of adult patients with schizophrenia

Neuropsychiatric Disease and Treatment, 2010
Rosaria Di Lorenzo1, Alice Brogli21Department of Mental Health, AUSL-MODENA, Presidio Psichiatrico di Diagnosi e Cura 1, NOCSAE, Baggiovara, Modena, Italy; 2School of Specialization in Psychiatry, University of Modena e Reggio Emilia, Modena ...
Rosaria Di Lorenzo, Alice Brogli
doaj  

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1331-1339, May 2026.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1179-1194, May 2026.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Initial dosage optimization of olanzapine in patients with bipolar disorder based on model-informed precision dosing: a study from the real world

Frontiers in Pharmacology
ObjectivesOlanzapine is used for treating bipolar disorder (BPD); however, the optimal initial dosing regimen is unclear. The present study aimed to investigate the optimal olanzapine initial dosage in patients with BPD via model-informed precision ...
Xiao Chen, Ke Hu, Hao-Zhe Shi, Liang Chen, Yi-Jia Zhang, Su-Mei He, Cun Zhang, Dong-Dong Wang   +7 more
doaj   +1 more source

The Effect of Iclepertin on Hematological Parameters: An Overview of Nonclinical Studies and Clinical Trials in Healthy Volunteers and Patients with Cognitive Impairment Associated with Schizophrenia

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract There are currently no approved pharmacotherapies to treat cognitive impairment associated with schizophrenia (CIAS). Iclepertin (BI 425809) is a selective glycine transporter‐1 (GlyT1) inhibitor that was investigated for the treatment of CIAS.
Peter Nagy, Justin Corey Fowler, Holger Rosenbrock, Wenbo Tang, Eric Fu, Annie Fraser, Holly Dursema, Julia Schlichtiger, Michael Desch, Fredrik Gruenenfelder   +9 more
wiley   +1 more source

Drug-drug interaction of paroxetine on olanzapine and initial dosage optimization in patients with major depressive disorder based on population pharmacokinetics

Frontiers in Psychiatry
ObjectiveOlanzapine is already used to treat patients with major depressive disorder; however, whether complex drug–drug interaction (DDI) has an effect on the pharmacokinetics of people using olanzapine and its initial dosage remains unknown.
Cun Zhang, Liang Chen, Yin-Yin Duan, Su-Mei He, Ya-Li Tian, Ying Gao, Dong-Dong Wang   +6 more
doaj   +1 more source

Pharmacological treatment strategies to manage precipitated withdrawal following the administration of buprenorphine in opioid use disorder: A systematic review

Addiction, Volume 121, Issue 5, Page 1083-1099, May 2026.
Abstract Background and aims There has been limited evidence synthesis examining the treatment of buprenorphine precipitated opioid withdrawal (BPOW). We aimed to conduct the first systematic review to assess the clinical utility of any pharmacological intervention in the management of BPOW.
Emmert Roberts, Nicola Kalk, John Strang
wiley   +1 more source