Results 51 to 60 of about 60,520 (273)

Pharmacovigilance on olanzapine

Indian Journal of Pharmacology, 2010
Sir, Pharmacovigilance, the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problems, is highly essential in India, where there is a lack of adequate efficacy and safety-related data, limited efforts made on adverse drug reaction (ADR) monitoring by the ...
Lingeswaran, Anand, Shetty, Harsha, Lahon, Kigshuk, Paramel, Amit, Sharma, Gyaneshwar   +4 more
openaire   +3 more sources

Effect of Continuing Olanzapine vs Placebo on Relapse Among Patients With Psychotic Depression in Remission: The STOP-PD II Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2019
Importance Psychotic depression is a severely disabling and potentially lethal disorder. Little is known about the efficacy and tolerability of continuing antipsychotic medication for patients with psychotic depression in remission.
A. Flint, B. Meyers, A. Rothschild, E. Whyte, G. Alexopoulos, M. Rudorfer, Patricia Marino, Samprit Banerjee, C. Pollari, Yi-Yuan Wu, A. Voineskos, B. Mulsant   +11 more
semanticscholar   +1 more source

Olanzapine-induced decreases of FGF21 in brown adipose tissue via histone modulations drive UCP1-dependent thermogenetic impairment

, 2023
Long-term olanzapine treatment has been associated with serious metabolism disorders, such as abnormal body weight gain, hyperglycemia, and dyslipidemia. Recently, accumulated evidence points to a link between the metabolic disorders caused by olanzapine
Xuemei Liu (630397), Haotian Zhang (4472800), Lu Liu (171341), Chao Deng (329151), Chang hua Hu (20274255), Shimei Zhang (20274249), Wenxing Mao (20274252)   +6 more
core   +1 more source

Fenofibrate Protects Against Antipsychotic-Induced Hyperglycemia Through Weight Loss and FGF21 Dependent Mechanisms. [PDF]

FASEB J
The proposed mechanism through which fenofibrate protects against olanzapine‐induced hyperglycemia in mice. ABSTRACT Antipsychotic (AP) medications, such as olanzapine, cause acute weight gain independent of hyperglycemia through a glucagon‐dependent mechanism.
Akcan M, Jeromson S, Baranowski BJ, Bellucci A, Trang S, Eisner K, Babicki-Moore A, Alfares H, Arbeau M, Medak K, Hahn M, Wright DC.   +11 more
europepmc   +2 more sources

Chronic olanzapine administration causes metabolic syndrome through inflammatory cytokines in rodent models of insulin resistance

Scientific Reports, 2019
Olanzapine is a second-generation anti-psychotic drug used to prevent neuroinflammation in patients with schizophrenia. However, the long-term administration of olanzapine leads to insulin resistance (IR); the mechanisms of this effect remains poorly ...
Huqun Li, Shi-Yong Peng, Shi-Hong Li, Shou-Qing Liu, Yifan Lv, Ni Yang, Liang-Yu Yu, Ya-Hui Deng, Zhong-Jian Zhang, Maosheng Fang, Yunxiang Huo, Ying Chen, T. Sun, Wei-Yong Li   +13 more
semanticscholar   +1 more source

Effect of Olanzapine on Metabolic Syndrome- A One Year Follow-up Study [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Patients with schizophrenia have increased risk of cardiovascular mortality and this is partly attributed to antipsychotics. Olanzapine, one of first line antipsychotic for the management of schizophrenia is associated with Metabolic ...
KJ Samyukta, D Shivson, Suvarna Jyothi Kantipudi   +2 more
doaj   +1 more source

A commentary on the efficacy of olanzapine for the treatment of schizophrenia: the past, present, and future

Neuropsychiatric Disease and Treatment, 2019
Olanzapine is a second-generation atypical antipsychotic with proven efficacy for the treatment of schizophrenia. Approved in 1996, olanzapine is one of the most studied antipsychotics, resulting in a considerable amount of clinical data across diverse ...
L. Citrome, J. Mcevoy, M. Todtenkopf, D. McDonnell, P. Weiden   +4 more
semanticscholar   +1 more source

Olanzapine monotherapy in posttraumatic stress disorder: Efficacy in a randomized, double-blind, placebo-controlled study

, 2012
ArticleObjectives Although there have been important advances in the treatment of posttraumatic stress disorder (PTSD), many patients fail to respond to first-line pharmacotherapy.
Seedat S., Stein D.J., Carey P., Suliman S., Ganesan K.   +4 more
core   +1 more source

Genetic Association of Olanzapine Treatment Response in Han Chinese Schizophrenia Patients

Frontiers in Pharmacology, 2019
Olanzapine, a second-generation antipsychotic medication, plays a critical role in current treatment of schizophrenia (SCZ). It has been observed that the olanzapine responses in schizophrenia treatment are different across individuals.
Wei Zhou, Yong Xu, Qinyu Lv, Yong-hui Sheng, Luan Chen, Mo Li, Lu Shen, Cong Huai, Zhenghui Yi, Donghong Cui, Donghong Cui, Shengying Qin, Shengying Qin   +12 more
doaj   +1 more source

Bilateral Basal Ganglion Hemorrhage after Severe Olanzapine Intoxication

Case Reports in Psychiatry, 2020
Olanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects. We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without ...
Kerstin Schweyer, Bastian Fatke, Kornelia Kreiser, Christian Rabe, Christian Seifert, Benno Ikenberg   +5 more
doaj   +1 more source