Results 71 to 80 of about 56,178 (231)

Adjunctive lurasidone suppresses food intake and weight gain associated with olanzapine administration in rats [PDF]

, 2019
Objective: Lurasidone is an antipsychotic drug that shows a relative lack of weight gain common to many antipsychotics. Aripiprazole and ziprasidone also show little weight gain and can reduce olanzapine-induced food intake and weight gain in animals ...
Dalton, Caroline, Harte, Michael K., Jackson, Joshua, Reynolds, Gavin, Watrimez, William   +4 more
core   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Early Lipid Metabolic Effects of the Anti-Psychotic Drug Olanzapine on Weight Gain and the Associated Gene Expression

Neuropsychiatric Disease and Treatment, 2022
Chien-Chih Chen,1,2 Toshiaki Nakano,3,4 Li-Wen Hsu,3,4 Chia Yi Chu,1 Kuang-Tzu Huang4,5 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2School of Medicine, Chang Gung ...
Chen CC, Nakano T, Hsu LW, Chu CY, Huang KT   +4 more
doaj  

Management of Agitation During the COVID-19 Pandemic [PDF]

, 2020
The coronavirus disease 2019 (COVID-19) pandemic caused by the coronavirus SARS-CoV-2 has radically altered delivery of care in emergency settings.
Chang, Bernard P., Powsner, Seth, Roppolo, Lynn P., Rozel, John S., Wilson, Michael P., Wong, Ambrose H., Yonkers, Kimberly A.   +6 more
core  

The longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: a post hoc analysis of data from a randomized, 1-year pragmatic trial [PDF]

, 2013
BACKGROUND: Schizophrenia is a highly heterogeneous disorder with positive and negative symptoms being characteristic manifestations of the disease. While these two symptom domains are usually construed as distinct and orthogonal, little is known about ...
Ascher-Svanum, H, Chen, L, Johnston, JA, Kinon, BJ, Marques, TR, Stauffer, V, Succop, P   +6 more
core   +2 more sources

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. [PDF]

, 2012
A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and ...
Belani, Chandra P, Bies, Robert R, Egorin, Merrill J, Ivy, Percy S, Lieberman, Jeffrey A, Manuck, Stephen B, Marder, Stephen R, Muldoon, Matthew F, Pollock, Bruce G, Sale, Mark E, Scher, Howard I, Sherer, Eric A, Solit, David B   +12 more
core   +3 more sources

Estado Confusional Agudo após Corticoterapia Inalada [PDF]

, 2017
Background: The connection between corticotherapy and neuropsychiatric symptoms is widely known, being one of the first questions we need to assess when presenting with first episode psychiatric symptoms or confusional state.
Monteiro, J, Mota, D, Ribeiro, L, Santos, M, Venâncio, A   +4 more
core  

Mono‐ and Bivalent Poly(iso‐butylene)‐Alanines for Drug‐Delivery of Nimodipine and Triamcinolone Acetonide

Macromolecular Rapid Communications, EarlyView.
Mono‐ and bivalent‐, alanine‐modified poly‐iso‐butylenes, folding into beta‐sheets, were prepared by living carbocationic polymerization and subsequent endgroup modification. These PIB‐conjugates are useful as solid polymers for the drug release of triamcinolone and nimodipine. ABSTRACT Poly‐iso‐butylene (PIB) is a well known biocompatible polymer with
Philipp S. Hilgeroth, Julius F. Butter, Wolfgang H. Binder   +2 more
wiley   +1 more source

a report of three cases [PDF]

, 2007
Context: Atypical antipsychotic agents (clozapine, olanzapine) have been linked to metabolic effects and acute pancreatitis. Case Report: We reviewed the inpatient and outpatient records of three patients who developed acute pancreatitis while being ...
Azar, Riad, Jonnalagadda, Sreenivasa, Kerr, T. A.   +2 more
core   +1 more source