Results 131 to 140 of about 17,456,883 (336)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Affirmative Old Age : the Ageing body and Feminist theories on Difference

, 2013
Discourses on old age and ageing are framed in narrow and binary ways, either as a decline narrative or through discourses of positive and successful ageing.
L. Sandberg
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Prediction of electroconvulsive therapy response and remission in late-life depression: a review

Swiss Medical Weekly
Electroconvulsive therapy is an effective and well-tolerated antidepressant treatment for the elderly population. The place of electroconvulsive therapy in the treatment sequence for depression in the elderly is currently not well established.
Beatriz Pozuelo Moyano, Kevin Swierkosz Lenart, Joëlle Rosselet Amoussou, Armin von Gunten, Jean-Pierre Schuster   +4 more
doaj   +1 more source

Race and Income Disparities in Disaster Preparedness in Old Age [PDF]

, 2017
Objective: Older adults are one of the most vulnerable populations impacted by disasters and communities continue to struggle addressing preparedness.
Cox, Katherine M.
core   +1 more source

Socioeconomic Inequalities in Mortality Rates in Old Age in the World Health Organization Europe Region

, 2013
Socioeconomic adversity is among the foremost fundamental causes of human suffering, and this is no less true in old age. Recent reports on socioeconomic inequalities in mortality rate in old age suggest that a low socioeconomic position continues to ...
Antunes, Avendano, Bassuk, Bopp, Borrell, Borrell, Borrell, Breeze, C. A. Towriss, Capewell, Cesaroni, Chaix, D. J. H. Deeg, Doblhammer, E. Grundy, Fernandez, Grundy, Harper, Hofer, Hoffmann, Hoffmann, Huisman, Huisman, Huisman, Ishigami, Jaffe, Jaffe, Kalediene, Leinsalu, Levin, Lorant, M. Huisman, Mackenbach, Mackenbach, Manor, Manor, Manor, Marinacci, Martelin, Martikainen, Martikainen, Martikainen, Martikainen, Martikainen, Merlo, Michelozzi, Minkler, Noale, O'Reilly, Penninx, Rey, ROSSUM, Rosvall, S. Read, Schiaffino, Strand, Valkonen, Van der Heyden, Vaupel, Walter   +59 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Modelling Intermediate Age and Old Stellar Populations in the Infrared [PDF]

, 1997
We have investigated the spectro-photometric properties of the Asymptotic Giant Branch (AGB) stars and their contribution to the integrated infrared emission in simple stellar populations (SSP).
Bressan, A., Granato, G. L., Silva, L.
core   +3 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source