Results 51 to 60 of about 7,347,462 (301)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A qualitative focus group study on legal experts’ views regarding euthanasia requests based on an advance euthanasia directive

BMC Medical Ethics
Background The Dutch Euthanasia law permits euthanasia in patients with advanced dementia lacking decisional capacity based on advance euthanasia directives.
D. O. Coers, S. H. Scholten, M. E. de Boer, E. M. Sizoo, M. A. J. M. Buijsen, B. J. M. Frederiks, C. J. W. Leget, C. M. P. M. Hertogh   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Wessex Acute Frailty Audit: applying quality improvement methodology to design and implement a regional frailty audit using a collaborative, multiprofessional approach

BMJ Open Quality, 2020
Introduction An acute hospital stay increases the risk of negative outcomes for those living with frailty. This paper describes the application of quality improvement methodology to design and implement a regional audit to gain an understanding of care ...
Teresa Corbett, Kathy Wallis, Cheryl Davies, Lucy Anne Lewis, Kerry Burrows, Claire Spice   +5 more
doaj   +1 more source

Health and functional status among older people with HIV/AIDS in Uganda [PDF]

, 2011
Background: In sub-Saharan Africa, little is known about the health and functional status of older people who either themselves are HIV infected or are affected by HIV and AIDS in the family.
Naidoo, Nirmala, Eugene Kinyanda, Janet Seeley, Somnath Chatterji, Kinyanda, Eugene, Naidoo Nirmala, Nirmala Naidoo, Chatterji, Somnath, Mugisha Joseph, Joseph Mugisha, Kinyanda Eugene, Nakubukwa, Susan, Boerma, Ties, Mugisha, Joseph, Scholten Francien, Kowal, Paul, Seeley, Janet, Kowal Paul, Francien Scholten, Chatterji Somnath, Heiner Grosskurth, Susan Nakubukwa, Ties Boerma, Scholten, Francien, Nakubukwa Susan, Grosskurth Heiner, Paul Kowal, Seeley Janet, Grosskurth, Heiner, Boerma Ties   +29 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Home-based geriatric rehabilitation after inpatient rehabilitation: a redesign and feasibility study

BMC Geriatrics
Background There is a shift from inpatient to home-based geriatric rehabilitation (HBGR), and potential benefits are demonstrated. Previously, a theoretical HBGR model, version 1.0, has been developed, outlining its essential components.
Astrid D. Preitschopf, Margriet Pol, Bianca Buurman, Marije Holstege   +3 more
doaj   +1 more source

What works in health promotion for older people? / National Council on Ageing and Older People [PDF]

, 1999
National Council on Ageing and Older People ...
National Council on Ageing and Older People (NCAOP)
core  

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Establishing the core elements of a frailty at the front door model of care using a modified real-time Delphi technique

BMC Emergency Medicine, 2023
Background Innovations in models of care for older adults living with frailty presenting to the emergency department (ED) have become a key priority for clinicians, researchers and policymakers due to the deleterious outcomes older adults experience due ...
Íde O’Shaughnessy, Christine Fitzgerald, Aoife Whiston, Patrick Harnett, Helen Whitty, Des Mulligan, Marian Mullaney, Catherine Devaney, Deirdre Lang, Jennifer Hardimann, Brian Condon, Christina Hayes, Alison Holmes, Louise Barry, Claire McCormack, Megan Bounds, Katie Robinson, Margaret O’Connor, Damien Ryan, Denys Shchetkovsky, Fiona Steed, Leonora Carey, Emer Ahern, Rose Galvin   +23 more
doaj   +1 more source