Results 121 to 130 of about 265,817 (310)

Supporting older workers to work: a systematic review

open access: yes, 2019
Purpose: The purpose of this paper is to identify what work-related factors influence the continued participation of older workers in the workforce. Design/methodology/approach: A systematic quantitative literature review of the workforce participation ...
Gardiner, E, Chen, MKL
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Do Older Workers Have More Trouble Using a Computer Than Younger Workers?

open access: yes
Technological change is often perceived to harm the position of the incumbent workforce compared to new entrants. Particularly the labor-market position of older workers, who are thought to have lower abilities or incentives to acquire new skills, might ...
Weel,Bas,ter, Borghans,Lex
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Firm-Sponsored Classroom Training: Is It Worth It For Older Workers? [PDF]

open access: yes
We use longitudinal linked employer-employee data and find that the probability of participating in firm-sponsored classroom training diminishes rapidly for workers aged 45 years and older.
Pierre Thomas Léger, Benoit Dostie
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Older workers in Australia: A policy perspective

open access: yes
The paper seeks to offer an objective assessment of Australian attitudes towards ageing and age discrimination, through an examination of the literature, the laws, and the current perspectives on workforce ageing.
Syed, Jawad
core  

Theoretical perspectives of older workers : integrating human resource management practices with resource-based strategies

open access: yes, 2011
Governments and policy makers throughout the developed world have encouraged employers for almost two decades to change early retirement policies and retain older workers.
Murray, Peter A.   +1 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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