Results 81 to 90 of about 92,881 (268)

P3‐602: OLDEST‐OLDS IN LATIN AMERICA: A NATURALISTIC ANALYSIS OVER NORMAL AGING AND SUPERAGING [PDF]

, 2019
Ismael Luis Calandri, Lucía Crivelli, María Martín, Noelia Egido, Ricardo Allegri   +4 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

BOSTON AGING TOGETHER STUDY: ATTITUDES TOWARD OWN AGING AMONG OLDEST-OLD PARENTS AND CHILDREN [PDF]

, 2019
Yijung K. Kim, Kathrin Boerner, Kyungmin Kim, Daniela S. Jopp   +3 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

452 ONE-YEAR OUTCOMES OF DIFFERENT ANTITHROMBOTIC STRATEGIES IN OLDEST OLD STEMI PATIENTS WITH NEW ONSET ATRIAL FIBRILLATION [PDF]

, 2022
Alessandro Ruzzarin, Matthias Unterhuber, Francesca Baessato, Luca Donazzan   +3 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Frailty in younger-old and oldest-old adults in a context of high social vulnerability

, 2022
Maria Angélica Andreotti Diniz, Marisa Silvana Zazzetta, Grace Angélica de Oliveira Gomes, Fabiana de Souza Orlandi, Luciana Kusumota, Aline Cristina Martins Gratão   +5 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Prospective Study of Diet Quality and the Risk of Dementia in the Oldest Old

, 2022
Ashley C. Flores, Gordon L. Jensen, Diane C. Mitchell, Muzi Na, G. Craig Wood, Christopher D. Still, Xiang Gao   +6 more
openalex   +1 more source

Disconnection of the right superior parietal lobule from the precuneus is associated with memory impairment in oldest-old Alzheimer's disease patients [PDF]

, 2020
Pukovisa Prawiroharjo, Kenichiro Yamashita, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Ryo Yamasaki, Jun‐ichi Kira   +6 more
openalex   +1 more source