Results 1 to 10 of about 2,519,723 (219)

Preparation and characterization of solidified oleanolic acid–phospholipid complex aiming to improve the dissolution of oleanolic acid [PDF]

Asian Journal of Pharmaceutical Sciences, 2016
The purpose of this study was to prepare the oleanolic acid–phospholipid complex (OA-PC) and then solidify it employing fumed silica by simple solvent evaporation technique to improve dissolution rate of oleanolic acid and oleanolic acid–phospholipid ...
Xiaoxu Yang, Qikun Jiang, Ping Du, Juanhang Zhao, Tianhong Zhang   +4 more
doaj   +5 more sources

Application and Development of Natural Plant Metabolite Oleanolic Acid in the Nano Era

Agriculture, 2022
Like other pentacyclic triterpenoids, oleanolic acid, a natural plant metabolite prevalent in plant peels, stems, and leaves, is regarded as a possible drug candidate.
Kun Wang, Qinyue Lu, Xiang Cao, Yuhao Wang, Yanni Wu, Zhi Chen, Zhangping Yang   +6 more
doaj   +2 more sources

Economically viable isolation and characterization of oleanolic acid from Eugenia caryophyllus (Spreng.) [PDF]

Kuwait Journal of Science, 2020
Oleanolic acid, an interesting molecule found widespread throughout the plant kingdom with promising pharmacological activities. However, the utilization of oleanolic acid in the modern therapy is quite difficult due to lack of proper isolation method ...
Nilesh Bhimrao Banarase, Chanchal Deep Kaur   +1 more
doaj   +2 more sources

Targeting Oxidative Stress in Carcinogenesis: Oleanolic Acid and Its Molecular Pathways [PDF]

Antioxidants
This narrative review aims to systematize the current knowledge on the dual role of reactive oxygen species and reactive nitrogen species in cancer processes, from their physiological function in redox signaling to their pathological impact in oxidative ...
Andrzej Günther, Maciej Kulawik, Szymon Sip, Przemysław Zalewski, Donata Jarmołowska-Jurczyszyn, Przemysław Stawicki, Barbara Bednarczyk-Cwynar   +6 more
doaj   +2 more sources

Study of the Stability and Anti-Inflammatory Activity of Paeonol–Oleanolic Acid Liposomes by Microfluidic Technology [PDF]

Foods
(1) Background: This study used a microfluidic approach to prepare paeonol (PAE) liposomes with oleanolic acid (PAE-ONLs) instead of cholesterol (PAE-CNLs), aiming to reduce cholesterol levels and enhance stability and anti-inflammatory activity.
Xianzheng Ma, Hui Zhang, Jinkai Luan, Mingfa Tian, Xiuxin Zhang, Ammara Sohail, Dong Liang, Jiguo Liu, Fuzhan Tao, Zheng Wang, Daijie Wang   +10 more
doaj   +2 more sources

Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases

Molecules, 2017
The increasing demand for natural products as an alternative therapy for chronic diseases has encouraged research into the pharmacological importance of bioactive compounds from plants.
Taiwo Betty Ayeleso, Mashudu Given Matumba, Emmanuel Mukwevho   +2 more
doaj   +3 more sources

Integrated transcriptome-metabolome analysis reveals oleanolic acid as a central regulator of heat stress adaptation in Rhododendron moulmainense [PDF]

BMC Plant Biology
Background Alpine rhododendron has high ornamental value because of its vibrant color. However, growing them in urban landscapes is challenging, as high temperatures can slow the growth of Rhododendron roots and cause leaf burning.
Sijia Liu, Luwen Zhang, Yuqing Bai, Peng Zhuang, Hongyue Cai, Jingen Peng, Zipeng Cai, Bing Hu, Xin Mao, Lijuan Xie   +9 more
doaj   +2 more sources

Greener approach for the isolation of oleanolic acid from Nepeta leucophylla Benth. Its derivatization and their molecular docking as antibacterial and antiviral agents

Heliyon, 2023
In the present study bioactive methanolic extract along with chloroform and hexane extracts obtained from shade dried leaves of the Himalayan aromatic medicinal plant Nepeta leucophylla Benth.
Ajay Sharma, Deepika Kathuria, Bhaskor Kolita, Apurba Gohain, Ashoke Kumar Das, Garima Bhardwaj, Jesus Simal-Gandara   +6 more
doaj   +1 more source

Identification of Oleanolic Acid as Allosteric Agonist of Integrin αM by Combination of In Silico Modeling and In Vitro Analysis

Frontiers in Pharmacology, 2021
Oleanolic acid is a widely distributed natural product, which possesses promising antitumor, antiviral, antihyperlipidemic, and anti-inflammatory activities. A heterodimeric complex formed by integrin αM (CD11b) and integrin β2 (CD18) is highly expressed
Lu Jin, Lu Jin, Xiaoyu Han, Xinlei Zhang, Zhimin Zhao, Judith Ulrich, Tatiana Syrovets, Thomas Simmet   +7 more
doaj   +1 more source

Oleanolic acid 3-acetate, a minor element of ginsenosides, induces apoptotic cell death in ovarian carcinoma and endometrial carcinoma cells via the involvement of a reactive oxygen species–independent mitochondrial pathway

Journal of Ginseng Research, 2020
Objectives: Oleanolic acid, a minor element of ginsenosides, and its derivatives have been shown to have cytotoxicity against some tumor cells. The impact of cytotoxic effect of oleanolic acid 3-acetate on ovarian cancer SKOV3 cells and endometrial ...
Hantae Jo, Jeong-Hyun Oh, Dong-Wook Park, Changho Lee, Churl K. Min   +4 more
doaj   +1 more source