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Frontiers in Plant Science, 2022 Oleanolic acid is a pentacyclic triterpenoid found in numerous plant species and is a precursor to several bioactive triterpenoids with commercial potential.
Jutapat Romsuk +9 more
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Oleanolic acid as a potential drug molecule: A review
, 2023 Objective: Oleanolic acid is traditionally used medicinal remedies in India. Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free
Mayuri I Sonawane +2 more
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Oleanolic acid enhances insulin secretion in pancreatic β-cells [PDF]
, 2008 We investigated the effect of oleanolic acid, a plant-derived triterpenoid, on insulin secretion and content in pancreatic β-cells and rat islets. Oleanolic acid significantly enhanced insulin secretion at basal and stimulatory glucose concentrations in ...
Vranic, M. +11 more
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Comparison of the inhibition capability of oleanolic acid and betulinic acid towards drug-metabolizing enzymes [PDF]
, 2015 Background: Human UDP-glucuronosyltransferases (UGTs) are important membrane proteins located in endoplasmic reticulum, and play important roles in metabolism of a variety of endogenous and exogenous compounds.Aims: To determine the influence of subtle ...
Lu, M, Lu, Meng-Hou, Xiao, Wei, Xiao, W
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Molbank, 2023 In this study, the synthesis and biological activities of previously and newly synthesized oleanolic acid derivatives containing seven-membered cyclic amines at the C28 position were described.
Anastasiya V. Petrova +2 more
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Viral UL8 Is Involved in the Antiviral Activity of Oleanolic Acid Against HSV-1 Infection
Frontiers in Microbiology, 2021 Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can cause severe diseases, especially in immunocompromised adults and newborns, such as keratitis and herpes simplex encephalitis. At present, the clinical therapeutic drug against HSV-
Tianhao Shan +43 more
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Enhancement of Platelet Aggregation by Ursolic Acid and Oleanolic Acid [PDF]
Biomolecules & Therapeutics, 2014 The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact or intentional use. Although they have diverse health benefits, reported cardiovascular protective activity is contentious. In this study, the effect of UA and
Kim, Mikyung +2 more
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3-beta-hydroxyolean-12-en-28-oic acid (oleanolic acid) [PDF]
, 1998 An industrial procedure has been established for the isolation of 3-beta-hydroxyolean-12-en-28-oic acid (oleanolic acid) starting from olive fruits (Olea europaea).[...
Parra Sánchez, Andrés +10 more
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Three Oleanolic Acid Glycosides from the Seeds of
Natural Product Communications, 2007 From the seeds of Achyranthes aspera three triterpenoid glycosides were isolated and their structures elucidated on the basis of NMR spectroscopic, mass spectrometric and degradative studies as α-L-rhamnopyranosyl-(1→4)-(β-D-glucopyranosyluronic acid)-(1→
Rashmi, Rameshwar Dayal, Akito Nagatsu
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PLoS ONE, 2020 Triterpenoids are high-value plant metabolites with numerous applications in medicine, agriculture, food, and home and personal care products. However, plants produce triterpenoids in low abundance, and their complex structures make their chemical ...
Matthew P Dale +3 more
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