Results 141 to 150 of about 11,485 (176)

Development and validation of an HPLC method for determination of oleanolic acid content and partition of oleanolic acid in submicron emulsions

Die Pharmazie, 2009
The aim of this study was to develop and validate a simple HPLC method for the quantitative determination of the oleanolic acid (OA) content and partition coefficient of OA in a submicron emulsion-based formulation (SE-OA). A DiamonsilTM C18 (150 mm × 4.6 mm, 5 μm) column was eluted with a mobile phase consisting of methanol/water (95 : 5, v/v).
Yong-Xing Zhao, Yong-Xing Zhao, Hay-Ying Hua, Hay-Ying Hua, Lin Liu, Lin Liu   +2 more
openaire   +2 more sources

Synthesis and cytotoxicity of oleanolic acid trisaccharide saponins

Carbohydrate Research, 2017
An array of oleanolic acid-type saponins based on β-hederin has been synthesized in a linear or one-pot manner. The cell viability assays indicate that synthetic saponins show antiproliferation activities in three cancer cell lines with IC50 values of 2.4-15.1 μM and hederacolchiside A1 being the most potent.
Liming, Wang, Zengshang, Wang, Sheng, Su, Ying, Xing, Yali, Li, Ming, Li, Jiangyun, Liu, Shilin, Yang   +7 more
openaire   +2 more sources

Structural Features of Mixed Monolayers of Oleanolic Acid and Stearic Acid

The Journal of Physical Chemistry C, 2008
The features of oleanolic acid at interfaces and its effect on another component of the epicuticular wax are studied using a binary monolayer system consisting of oleanolic acid (OLA) and stearic acid (SA). A combination of lateral pressure studies, grazing incidence X-ray diffraction (GIXD), and specular X-ray reflectivity (SR) measurements, is proven
Brezesinski, G., Vollhardt, D., Iimura, K., Cölfen, H.   +3 more
openaire   +3 more sources

Effects of oleanolic acid and maslinic acid on hyperlipidemia

Drug Development Research, 2007
AbstractIn the present study, we examined the therapeutic effects of pentacyclic triterpenes, oleanolic acid (OA) and maslinic acid (MA), on hyperlipidemia in a high‐cholesterol diet model. Hyperlipidemia was induced in male Sprague‐Dawley rats by feeding with a high‐cholesterol diet (HCD) for 30 days. MA and OA were supplemented (100 mg/kg body wt/day)
Jun Liu, Hongbin Sun, Xiaofen Wang, Dongyan Mu, Hong Liao, Luyong Zhang   +5 more
openaire   +1 more source

Determination of Ursolic and Oleanolic Acid in Sambuci Fructus

Chemistry & Biodiversity, 2014
AbstractElderberries are used in the preparation of pie, jelly, punch, wine, or liqueur, as well as in many herbal remedies and food supplements. Elderberry products may provide diaphoretic, diuretic, antioxidant, and immunostimulant activities that offer protection against cold and flu.
Michał, Gleńsk, Jan A, Gliński, Maciej, Włodarczyk, Piotr, Stefanowicz   +3 more
openaire   +3 more sources

Generation and Characterisation of Monoclonal Antibodies to Oleanolic Acid

Planta Medica, 2004
Monoclonal antibodies to oleanolic acid, a pentacyclic triterpene, were generated using the hybridoma fusion method described by Kohler and Milstein . Protein conjugates of the target molecule for immunisation were prepared either by directly linking the isoprenoid to different protein carriers via the carboxylic function or after introduction of a ...
K M, Brand, C, Klein, I, Zündorf, T, Dingermann, W, Knöss   +4 more
openaire   +2 more sources

Biotransformation of oleanolic and maslinic acids by Rhizomucor miehei

Phytochemistry, 2013
Microbial transformation of oleanolic acid by Rhizomucor miehei produced three metabolites. A known compound, a 30-hydroxyl derivative (queretaroic acid), and two 7β,30- and 1β,30-dihydroxylated metabolites, respectively. The action of the same fungus (R.
Antonio, Martinez, Francisco, Rivas, Alberto, Perojil, Andres, Parra, Andres, Garcia-Granados, Antonia, Fernandez-Vivas   +5 more
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Synthesis and cytotoxicity evaluation of oleanolic acid derivatives

Bioorganic & Medicinal Chemistry Letters, 2013
Twelve derivatives of oleanolic acid (1) have been synthesized and evaluated for their inhibitory activities against the growth of prostate PC3, breast MCF-7, lung A549, and gastric BGC-823 cancer cells by MTT assays. Within these series of derivatives, compound 17 exhibited the most potent cytotoxicity against PC3 cell line (IC50=0.39 μM) and compound
Jia, Hao, Jun, Liu, Xiaoan, Wen, Hongbin, Sun   +3 more
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[Survey of pharmacology of oleanolic acid].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2003
To summarize the pharmacological function of oleanolic acid.Based on the documents and related achievements, the pharmacological function and its mechanism including its clinical use were summed up.Oleanolic Acid is a natural chemical which has wide-ranging function and abundant source.
Li-ting, Tian, Long, Ma, Nian-sheng, Du
openaire   +1 more source

Protective effects of ursolic acid and oleanolic acid in leukemic cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2006
Ursolic acid (UA) and oleanolic acid (OA) have similar chemical structures but differ in the position of one methyl group on the ring E. We investigated protective effects of these two triterpenoic acids against H(2)O(2)-induced DNA damage in leukemic L1210, K562 and HL-60 cells using single-cell gel electrophoresis (SCGE). We compared their protective
Zdenka, Ovesná, Katarína, Kozics, Darina, Slamenová   +2 more
openaire   +2 more sources