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Oleanolic Acid: Extraction, Characterization and Biological Activity [PDF]

Nutrients, 2022
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is receiving outstanding attention from the scientific community due to its biological activity against multiple diseases. Oleanolic acid is endowed with a wide range of biological activities with therapeutic potential by means of complex and multifactorial mechanisms.
JOSÉ Maria Castellano, Sara Ramos-Romero, Javier S Perona   +2 more
exaly   +4 more sources

Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases

Molecules, 2017
The increasing demand for natural products as an alternative therapy for chronic diseases has encouraged research into the pharmacological importance of bioactive compounds from plants.
Taiwo Betty Ayeleso, Emmanuel Mukwevho
exaly   +3 more sources

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Oleanolic Acid in Lardizabala biternata

Journal of Pharmaceutical Sciences, 1961
Oleanolic acid was isolated and identified as a sapogenin of a glycosidic fraction from Lardizabala biternata. By means of an alcoholic extraction of the dried and pulverized plant an extract was obtained which yielded a water-soluble glycosidic fraction. Acid hydrolysis of this material gave oleanolic acid which was purified and identified.
M, SILVA, P, MANCINELLI
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Oleanolic Acid from Cranberries*

Journal of the American Pharmaceutical Association (Scientific ed.), 1953
A modified procedure, involvin decolorization of the ammonium salt, is feescribed for the purification of crude ursolic acid obtained from cranberries. Oleanolic acid was isolated from the mother liquors remaining from the final recrystallization of the purified product.
B Y, WU, L M, PARKS
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Succinyl Oleanolic Acid

Acta Crystallographica Section C Crystal Structure Communications, 1997
The title compound, 3-[(2-carboxyethyl)carbonyloxy]-olean-12-en-28-oic acid, C34H5206, was synthesized as a derivative of oleanolic acid in order to improve its solubility and bioavailability. It has been used as an anti-inflammatory and antihepatitis drug in east Asia.
J. Yang, J. W. Quail, Z. Jia
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Solubilization of oleanolic acid and ursolic acid by cosolvency

Archives of Pharmacal Research, 1997
Solubilities of oleanolic acid and ursolic acid in aqueous surfactant solutions, liquid polyethylene glycols (PEG), and solvents of various polarity were measured. The results showed that the solutes were slightly or moderately solubilized in the surfactant solutions and the liquid PEGs.
I J, Jin, Y I, Ko, Y M, Kim, S K, Han
openaire   +2 more sources

Oleanolic acid and ursolic acid stabilize liposomal membranes

Lipids, 1997
AbstractThe effects of oleanolic acid (OA) and ursolic acid (UA) on the fluidity and stability of dipalmitoyl phosphatidylcholine (DPPC) liposomal membrane were monitored by measuring the fluorescence polarization of 1,6‐diphenyl‐1,3,5‐hexatriene labeled in the liposomal membrane and the leakage of calcein from the probe‐encapsulated liposomes.
S K, Han, Y I, Ko, S J, Park, I J, Jin, Y M, Kim   +4 more
openaire   +2 more sources

Conversion of α- and β-amyrin into ursolic and oleanolic acids respectively. A synthesis of oleanolic acid

J. Chem. Soc. C, 1970
β-Amyrin has been converted into 3β-acetoxy-13-hydroxyoleanane. Photolysis of the nitrite of this alcohol and further standard transformations gave oleanolic acid lactone acetate and thence oleanolic acid. This conversion of β-amyrin into oleanolic acid represents, in the formal sense, a total synthesis of the latter.By a similar series of reactions ...
R. B. Boar, D. C. Knight, J. F. McGhie, D. H. R. Barton   +3 more
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Synthesis of glycosides of oleanolic acid

Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1966
1. The synthesis of glycosides of oleanolic acid has been carried out. 2. On the basis of the synthesis of the glucoside of oleanolic acid, the possibility of using sugar orthoesters for the selective glycosylation of the alcoholic hydroxy group of a hydroxy acid containing an unprotected carboxyl has been shown.
N. K. Kochetkov, A. Ya. Khorlin, A. F. Bochkov, L. G. Kretsu   +3 more
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Nature of the transformations of oleanolic acid in an acid medium

Chemistry of Natural Compounds, 1986
3-Trifluoroacetoxyoleanolic acid and 3-trifluoroacetoxyolean-13(18)-en-28-oic acid have been isolated from the mixture of the products of the transformation of oleanolic acid in a trifluoroacetic acid medium, and their structures have been established with the aid of IR, PMR and mass spectra.
A. A. Savina, D. A. Fesenko, V. I. Sheichenko, A. N. Shavlinskii   +3 more
openaire   +1 more source