Results 281 to 290 of about 250,076 (386)

Post‐Covid Alzheimer and Its Remediation via PROTACs Therapy: A Comprehensive Review

open access: yesHealth Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Alzheimer's disease (AD) is a progressive neurodegenerative disorder of aging characterized by memory loss and cognitive decline, associated with amyloid‐β toxicity, tau hyperphosphorylation, and neurofibrillary tangle formation. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) affects the central nervous system
Teesta Bhowmick   +5 more
wiley   +1 more source

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel   +5 more
wiley   +1 more source

Olfactory bulb stimulation mitigates Alzheimer's-like disease progression. [PDF]

open access: yesCNS Neurosci Ther
Salimi M   +6 more
europepmc   +1 more source

Energy Metabolism Under Stress: Late‐Stage Leigh Syndrome Reveals Profound Cardiometabolic Perturbations in Ndufs4 KO Mice

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
Cardiac bioenergetic and metabolic perturbations in late‐stage Leigh syndrome. Whole‐body NDUFS4 loss severely impairs cardiac complex I activity and respiration, shifting reliance to complex II and reducing glycolytic, TCA, and amino acid‐derived energy‐generating substrates in the heart.
Karin Terburgh   +2 more
wiley   +1 more source

Regional and Cellular Codistribution of Interleukin lß and Nerve Growth Factor rnRNA in the Adult Rat Brain [PDF]

open access: yes, 1990
Bandtlow, C. E.   +5 more
core  

Assessment of Small Vessel Density Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalophy (CADASIL) by High‐Resolution Black‐Blood MRI

open access: yesJournal of Magnetic Resonance Imaging, Volume 63, Issue 1, Page 157-168, January 2026.
ABSTRACT Background Direct assessments of cerebral small vessels in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) remain a challenge. Purpose To investigate changes of cerebral small vessels in CADASIL using iso‐0.5 mm black‐blood MRI. Study Type Case control study.
Zidong Yang   +9 more
wiley   +1 more source

The Functional Epididymal Amyloid Cystatin‐Related Epididymal Spermatogenic (CRES) is a Component of the Mammalian Brain Extracellular Matrix

open access: yesJournal of Neuroscience Research, Volume 104, Issue 1, January 2026.
This study investigated if the epididymal amyloid CRES (cystatin‐related epididymal spermatogenic) is present in the male and female mammalian brain. CRES is expressed by hippocampal astrocytes, CA2 and CA3 neurons, and exhibits amyloid properties in the extracellular matrix.
Alejandra Gomez   +3 more
wiley   +1 more source

Differential functional change in olfactory bulb and olfactory eloquent areas in Parkinson's disease. [PDF]

open access: yesBrain Commun
Luo Y   +8 more
europepmc   +1 more source

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