Results 61 to 70 of about 339,145 (335)

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term

Acta Neuropathologica, 2017
Parkinson’s disease is characterized by degeneration of substantia nigra dopamine neurons and by intraneuronal aggregates, primarily composed of misfolded α-synuclein.
Nolwen L. Rey, Sonia George, Jennifer A. Steiner, Zachary B. Madaj, Kelvin C. Luk, J. Trojanowski, V. Lee, P. Brundin   +7 more
semanticscholar   +1 more source

Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors [PDF]

, 2005
Genetic perturbations of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory.
Shimshek Derya R, Mack Volker, Derya R Shimshek, Peter H Seeburg, Sprengel, Rolf, Bus, T, Mihaljevic Andre, Bus, T., Sprengel, R, Kim Jinhyun, Schaefer, AT, Mihaljevic, A, Thorsten Bus (71683), Peter H Seeburg (71687), Shimshek, DR, Rolf Sprengel (71688), Schaefer, Andreas T., Seeburg, P., Jinhyun Kim, Andre Mihaljevic, Volker Mack (71686), Mihaljevic, André, Shimshek, Derya R., Derya R Shimshek (71682), Bus, Thorsten, Seeburg, Peter H., Rolf Sprengel, Kim, Jinhyun, Mack, V, Schaefer, A., Bus Thorsten, Schaefer Andreas T, Jinhyun Kim (71684), Kim, J, Seeburg Peter H, Seeburg, PH, Kim, J., Thorsten Bus, Andreas T Schaefer, Shimshek, D., Mack, Volker, Sprengel Rolf, Mack, V., Andre Mihaljevic (71685), Volker Mack, Mihaljevic, A., Sprengel, R., Andreas T Schaefer (71689)   +47 more
core   +1 more source

Investigating Olfactory Bulb Volume Reduction as a Potential Biomarker for Some Neuropsychiatric Disorders: A Narrative Review

Journal of Clinical and Basic Research, 2021
The Olfactory bulb is a crucial structure involved in olfaction that is located in the ventral anterior of the forebrain. Due to physiological and anatomical connection between olfactory and emotion processing networks, olfactory dysfunction is seen in ...
Hamed Hajishah, Seyyed Amirhossein Salehi, Mohammadjavad Amini   +2 more
doaj  

MR Imaging–Based Evaluations of Olfactory Bulb Atrophy in Patients with Olfactory Dysfunction

American Journal of Neuroradiology, 2017
BACKGROUND AND PURPOSE: Although the olfactory bulb volume as assessed with MR imaging is known to reflect olfactory function, it is not always measured during olfactory pathway assessments in clinical settings. We aimed to evaluate the utility of visual
M. Chung, W. R. Choi, Hyeon-Yeong Jeong, Jungbok Lee, Jin-Ho Kim   +4 more
semanticscholar   +1 more source

Neurog1 and Neurog2 coordinately regulate development of the olfactory system

Neural Development, 2012
Background Proneural genes encode basic helix–loop–helix transcription factors that specify distinct neuronal identities in different regions of the nervous system.
Shaker Tarek, Dennis Daniel, Kurrasch Deborah M, Schuurmans Carol   +3 more
doaj   +1 more source

Increases of Phosphorylated Tau (Ser202/Thr205) in the Olfactory Regions Are Associated with Impaired EEG and Olfactory Behavior in Traumatic Brain Injury Mice

Biomedicines, 2022
Traumatic brain injury (TBI) leads to long-term cognitive impairments, with an increased risk for neurodegenerative and psychiatric disorders. Among these various impairments, olfactory dysfunction is one of the most common symptoms in TBI patients ...
Younghyun Yoon, SuHyun Kim, YunHee Seol, Hyoenjoo Im, Uiyeol Park, Hio-Been Han, Jee Hyun Choi, Hoon Ryu   +7 more
doaj   +1 more source

Microplastics in the Olfactory Bulb of the Human Brain

JAMA Network Open
Key Points Question Can microplastics reach the olfactory bulb in the human brain? Findings This case series analyzed the olfactory bulbs of 15 deceased individuals via micro-Fourier transform infrared spectroscopy and detected the presence of ...
L. F. Amato-Lourenço, K. C. Dantas, Gabriel Ribeiro, Vitor Ribeiro Paes, R. Ando, R. de Oliveira Freitas, O. D. da Costa, Renata S. Rabelo, Kelly Cristina Soares Bispo, Regiani Carvalho-Oliveira, Thais Mauad   +10 more
semanticscholar   +1 more source

Measuring the olfactory bulb input-output transformation reveals a contribution to the perception of odorant concentration invariance

Nature Communications, 2017
Humans and other animals can recognize an odorant as the same over a range of odorant concentrations. It remains unclear whether the olfactory bulb, the brain structure that mediates the first stage of olfactory information processing, participates in ...
Douglas A. Storace, L. Cohen
semanticscholar   +1 more source

Effects of intranasal instillation of nanoparticulate matter in the olfactory bulb

Scientific Reports, 2021
Nanoparticulate matter activates the aryl hydrocarbon receptor (AhR) pathway in the respiratory system in a process involving the AhR nuclear translocator (ARNT) and cytochrome P450 family 1, member A1 (CYP1A1).
So Young Kim, Kyung Woon Kim, So Min Lee, Sohyeon Park, Byeong-Gon Kim, Eun-kyung Choi, Bu Soon Son, Moo Kyun Park   +7 more
doaj   +1 more source

A ventral glomerular deficit in Parkinson’s disease revealed by whole olfactory bulb reconstruction

Brain : a journal of neurology, 2017
Olfactory dysfunction is common in Parkinson’s disease. Zapiec et al. devise a rigorous quantitative approach to describe the glomerular component of the entire human olfactory bulb.
Bolek Zapiec, B. Dieriks, Sheryl Tan, R. Faull, P. Mombaerts, M. Curtis   +5 more
semanticscholar   +1 more source