Results 51 to 60 of about 52,860 (309)

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Neurogenesis dynamics in the olfactory bulb: deciphering circuitry organization, function, and adaptive plasticity

Neural Regeneration Research
Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons.
Moawiah M. Naffaa
doaj   +1 more source

Greater addition of neurons to the olfactory bulb than to the cerebral cortex of eulipotyphlans but not rodents, afrotherians or primates

Frontiers in Neuroanatomy, 2014
The olfactory bulb is an evolutionarily old structure that antedates the appearance of a six-layered mammalian cerebral cortex. As such, the neuronal scaling rules that apply to scaling the mass of the olfactory bulb as a function of its number of ...
Pedro Furtado De Mattos Ribeiro, Paul eManger, Kenneth C Catania, Jon H Kaas, Suzana eHerculano-Houzel   +4 more
doaj   +1 more source

Consolidation of an olfactory memory trace in the olfactory bulb is required for learning-induced survival of adult-born neurons and long-term memory. [PDF]

PLoS ONE, 2010
BACKGROUND: It has recently been proposed that adult-born neurons in the olfactory bulb, whose survival is modulated by learning, support long-term olfactory memory.
Florence Kermen, Sébastien Sultan, Joëlle Sacquet, Nathalie Mandairon, Anne Didier   +4 more
doaj   +1 more source

Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis. [PDF]

Laryngoscope
This study investigated perioperative changes in olfactory bulb volume (OBV) in patients with eosinophilic chronic rhinosinusitis using high‐resolution 3T MRI. Postoperative increases in OBV were associated with improvements in olfactory identification, suggesting a potential link between olfactory bulb structural plasticity and functional recovery ...
Yamamoto K, Abukawa M, Okuni T, Nakanishi M, Sakurai Y, Yama N, Ogasawara N, Kamekura R, Takano K.   +8 more
europepmc   +2 more sources

Exploring olfactory sensory networks: Simulations and hardware emulation [PDF]

, 2010
Olfactory stimuli are represented in a highdimensional space by neural networks of the olfactory system. A great deal of research in olfaction has focused on this representation within the first processing stage, the olfactory bulb (vertebrates) or ...
Beyeler, Michael, Galizia, G, Fabio Stefanini, Henning Proske, Beyeler, M., Chicca, Elisabetta, Proske, H., Giovanni Galizia, Beyeler, M, Michael Beyeler, Chicca, E, Galizia, C. Giovanni, Stefanini, F., Proske, Henning, Proske, H, Elisabetta Chicca, Galizia, G., Stefanini, Fabio, Chicca, Elisabetta ; https://orcid.org/, Stefanini, F   +19 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

The Importance of Olfaction for Mixed Paternity in Birds

Ecology and Evolution
Olfaction can aid individuals in finding genetically compatible mates in many animals, while high levels of mixed paternity may result from a limited ability to evaluate their mate's genetic profile against their own before mating.
Charlotta Kvarnemo, Alice Anderstedt, Maria Strandh, Donald Blomqvist   +3 more
doaj   +1 more source

Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway

Journal of Neuroinflammation, 2012
Background The primary olfactory pathway is a potential route through which microorganisms from the periphery could potentially access the central nervous system.
Herbert Rosalind P, Harris Julie, Chong Kim, Chapman Jamie, West Adrian K, Chuah Meng   +5 more
doaj   +1 more source

Speckle-scale focusing in the diffusive regime with time-reversal of variance-encoded light (TROVE). [PDF]

, 2013
Focusing of light in the diffusive regime inside scattering media has long been considered impossible. Recently, this limitation has been overcome with time reversal of ultrasound-encoded light (TRUE), but the resolution of this approach is fundamentally
Wang, Ying Min, Mathy, Alexandre, Benjamin Judkewitz, Roarke Horstmeyer, Judkewitz, Benjamin, Yang, Changhuei, Changhuei Yang, Ying Min Wang, Alexandre Mathy, Horstmeyer, Roarke   +9 more
core   +1 more source