Two Parallel Olfactory Pathways for Processing General Odors in a Cockroach. [PDF]
Front Neural Circuits, 2017 In animals, sensory processing via parallel pathways, including the olfactory system, is a common design. However, the mechanisms that parallel pathways use to encode highly complex and dynamic odor signals remain unclear.
Watanabe H +3 more
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Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation. [PDF]
Front PharmacolDetection and discrimination of chemosensory stimuli (usually known as odorants) by the olfactory system exert a crucial role in animal survival. Olfactory receptors (ORs) are a large family of G protein-coupled receptors (GPCRs) mainly expressed by the ...
Amedei A, Parolini C.
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TRPV1-STAT3 signaling as a driver of lethal pathology during pneumococcal nose-to-brain invasion. [PDF]
Microbiol SpectrNose-to-brain infection represents a non-hematogenous route by which pathogens invade the central nervous system via neural pathways. The olfactory and trigeminal systems are implicated in this process, but the molecular mechanisms underlying lethal ...
Sakatani H +10 more
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Modelling Olfactory Dysfunction in Rodents Through Intranasal Vanadium Exposure. [PDF]
Animals (Basel)Olfactory dysfunction is increasingly recognized as an important consequence of exposure to environmental toxicants, owing to the anatomical and functional characteristics of the olfactory system, which allow inhaled toxicants to reach the central ...
Pereira M +4 more
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Olfactory dysfunction and submicroscopic abnormalities: unveiling hidden pathologies [PDF]
Front Mol NeurosciRecent advances in high-resolution genomic technologies have revealed that several syndromes are associated with submicroscopic chromosomal deletions and, less frequently, duplications, thereby substantially contributing to the functional annotation of ...
Bilińska K, Pasińska M, de Castro F.
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Dual Second-Messenger Pathways in Olfactory Transduction
Current Opinion in Neurobiology, 1995 Increasing evidence indicates that inositol phosphate as well as cyclic nucleotide signalling pathways mediate olfactory transduction. Both pathways can target multiple ion channel effectors, suggesting that olfactory receptor cells serve as more than simple selectivity filters and that they possibly represent the first stage of olfactory integration.
Asylbek B. Zhainazarov +2 more
exaly +4 more sources
Neuroinflammation in Alzheimer's disease-associated sensory dysfunction: mechanistic links, actionable targets and therapeutic strategies. [PDF]
Front Aging NeurosciAlzheimer’s disease (AD) is the most common cause of dementia and major public-health challenge in aging societies worldwide. Accumulating evidence suggests that olfactory and visual deficits can precede overt cognitive symptoms and are closely ...
Xu Y, Zhang G, Cui X, Sun L.
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Pathogenesis of Olfactory Disorders in COVID-19
Brain Sciences, 2022 Since the outbreak of the SARS-CoV-2 pandemic, olfactory disorders have been reported as a frequent symptom of COVID-19; however, its pathogenesis is still debated.
Laura Ziuzia-Januszewska +1 more
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Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma
Cancer Research Communications, 2023 Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding the mechanisms driving olfactory neuroblastoma pathobiology has been challenging.
John B. Finlay +4 more
openaire +2 more sources
Olfaction and Executive Cognitive Performance: A Systematic Review
Frontiers in Psychology, 2022 Objective tests of olfaction are widely available to aid in the assessment of olfaction. Their clearest role is in the characterization of olfactory changes, either reported by or suspected in a patient.
Vasudeva Murthy Challakere Ramaswamy +2 more
doaj +1 more source