Results 191 to 200 of about 50,072 (244)

ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1‐STAT3 Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
SQDHD exerts neuroprotective effects and alleviates behavioral deficits in PIL mice, likely by inhibiting the JAK1‐STAT3 pathway in activated CVECs. These findings underscore the therapeutic potential of SQDHD and establish it as a promising candidate for the treatment of NPSLE.
Jie Chen, Chumiao Cui, Fei Xu, Jiayan Feng, Jingyu Chen, Xueru Wang, Hui Yuan, Chenye Jin, Yutian Li, Yang Yun   +9 more
wiley   +1 more source

Olfactory dysfunction with traumatic brain injury and posttraumatic-stress symptoms in post-deployed military personnel. [PDF]

Front Neurol
Shura RD, Pickett TC, Powell J, Yoash-Gantz R, McDonald SD, Walker WC, Rowland JA, Tupler LA.   +7 more
europepmc   +1 more source

Effects of Tetrodotoxin on Safety, and Sensory and Respiratory Systems: A Dose‐Escalating Study in Healthy Volunteers

European Journal of Pain, Volume 30, Issue 3, March 2026.
ABSTRACT Background Chronic pain affects approximately 1.5 billion individuals worldwide, and currently available treatments often fail to provide adequate analgesia. Consequently, there is a need to explore novel analgesic compounds, including tetrodotoxin.
Kiki W. K. Kuijpers, Rutger Van Der Schrier, Albert Dahan, Monique Van Velzen   +3 more
wiley   +1 more source

Olfactory Dysfunction in Primary Ciliary Dyskinesia. [PDF]

OTO Open
Farzal Z, Sullivan KM, Zariwala MA, Thorp BD, Senior BA, Ebert CS, Davis S, Leigh MW, Knowles MR, Kimple AJ.   +9 more
europepmc   +1 more source

Nutritional Value and Memory‐Improving Effects of Seven Major Nuts: A Comprehensive Study Using Network Pharmacology and In Vivo Assays

Food Frontiers, Volume 7, Issue 2, March 2026.
This study highlights the memory‐enhancing effects of walnuts, almonds, and Torreya, with walnuts showing the strongest potential to improve cognitive function and delay brain aging. ABSTRACT This study explored the memory‐enhancing potential of seven commercially available nuts through nutritional profiling, metabolomics, network pharmacology, and ...
Jiamin Chen, Ben Niu, Ruiling Liu, Chaoyi Shen, Huizhi Chen, Mohamed A. Farag, Hangjun Chen, Qi Chen, Long Jin, Weijie Wu, Haiyan Gao   +10 more
wiley   +1 more source

Olfactory dysfunction and amyloid-positivity in Parkinson's disease-longitudinal analysis of cognitive decline and cerebrospinal fluid markers. [PDF]

PLoS One
Larsson V, Hall S, Blennow K, Hansson O.
europepmc   +1 more source

Neurobiological correlates of obsessive‐compulsive disorder (OCD): A narrative review

Ibrain, Volume 12, Issue 1, Page 86-95, Spring 2026.
Obsessive‐compulsive disorder (OCD) is a common and disabling, as well as underdiagnosed, neuropsychiatric condition characterized by involuntary and unwanted obsessions and/or compulsions often accompanied by states of severe anxiety, distress and shame, as well as other comorbid disorders. Despite the extensive literature available to date, only some
Giulio Perrotta, Anna Sara Liberati
wiley   +1 more source

Downregulating Platelet Endothelial Cell Adhesion Molecule‐1 Enhances Learning and Memory and Alleviates Hallmark Pathologies in Alzheimer's Disease

MedComm, Volume 7, Issue 3, March 2026.
CD31 upregulation in 5xFAD mice activates STAT1/Irf1 signaling, driving abnormal gene transcription, Aβ and tau accumulation, microglial activation, and neuroinflammation, leading to cognitive decline. Systemic CD31 knockdown suppresses STAT1/Irf1 activity, restores gene expression balance, reduces Aβ and tau pathologies, alleviates neuroinflammation ...
Qiuzhi Zhou, Fei Sun, Yao Zhang, Xiaojian Cao, Mengzhu Li, Haitao Yu, Tao Jiang, Shihong Li, Weixia Wang, Jiazhao Xie, Ting He, Yanchao Liu, Xiuping Liu, Ying Yang, Dan Ke, Xiao‐Chuan Wang, Enjie Liu, Jian‐Zhi Wang   +17 more
wiley   +1 more source

Aging and chronic inflammation: impacts on olfactory dysfunction-a comprehensive review. [PDF]

Cell Mol Life Sci
Xie Y, Wang S, Cha X, Li F, Xu Z, Wu J, Liu H, Ren W.   +7 more
europepmc   +1 more source

Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice

MedComm, Volume 7, Issue 3, March 2026.
PGC‑1α downregulation in hippocampal astrocytes disrupts ATP release and reduces connexin 43 (CX43) expression, impairing neuro‑glial communication. This promotes enhanced fear memory retrieval in PTSD. Chemogenetic activation of astrocytes or PGC‑1α agonist treatment rescues both CX43 expression and fear behavior, identifying astrocytic PGC‑1α/CX43 as
Juan Wang, Xiaoyu Chen, Daokang Chen, Shaojie Yang, Jingji Wang, Ming Chen, Guoqi Zhu   +6 more
wiley   +1 more source