Results 171 to 180 of about 52,033 (255)

Alcohol‐Induced Early‐Stage Liver Injury Contributes to Increases in Voluntary Alcohol Intake and Cognitive Deficits in Mice

open access: yesAlcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
While the liver–brain axis is well‐characterized in alcohol‐related disorders, the impact of alcohol‐associated liver disease (ALD) on alcohol use disorder (AUD)‐related behaviors remains unclear. This study investigated the effects of early‐stage ALD on alcohol consummatory behavior and cognitive function in C57BL/6 mice. Early ALD induced a transient
Samantha G. Skinner   +6 more
wiley   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 15, Page 4227-4245, August 2026.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda   +5 more
wiley   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6509-6532, August 2026.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano   +4 more
wiley   +1 more source

Decoding Prodromal Lewy Body Disease: Clinical Differences Between Isolated REM Sleep Behavior Disorder and Hyposmia With Dopamine Transporter Deficit

open access: yesEuropean Journal of Neurology, Volume 33, Issue 8, August 2026.
Isolated REM sleep behavior disorder (iRBD) [n = 360] and hyposmia with dopamine transporter deficit [n = 1101] represent two enriched prodromal Lewy body disease cohorts. Using data from the Parkinson's Progression Markers Initiative, iRBD was associated with significantly greater autonomic symptom burden than hyposmia, driven by constipation and ...
Luke Vikram Banerjee   +4 more
wiley   +1 more source

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

open access: yesInternational Journal of Cosmetic Science, Volume 48, Issue 4, Page 780-797, August 2026.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos   +3 more
wiley   +1 more source

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