Results 151 to 160 of about 653,353 (249)

The Gut–Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism‐Based Precision Medicine

Movement Disorders, EarlyView.
Abstract Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non‐motor symptoms to a central component of ...
Filip Scheperjans, Per Borghammer, Ronald F. Pfeiffer, Silke Appel‐Cresswell, Ali Keshavarzian   +4 more
wiley   +1 more source

Skin Seed Amplification Assay Differentiates Multiple System Atrophy from Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Misdiagnoses of multiple system atrophy (MSA) and Parkinson's disease (PD) remain common. Objective The objective of the study was to develop a skin α‐synuclein seed amplification assay (αSyn‐SAA) for detecting pathological α‐synuclein and distinguishing MSA from PD.
Anastasia Kuzkina, Diego Rodriguez, Celine Panzer, Alain Ndayisaba, Antonia Kohl, Shreya Rai, Breelyn Gilbert, Bruno Hammerschlag, Karie Shen, Lisa Harder‐Rauschenberger, Olivia Laun, Julia Meehan, Sucika Perumalla, Elena Salabasidou, Kristie Jones, Dalina Ceku, Robert Blum, Susanne Knorr, Camelia M. Monoranu, Claudia Sommer, Jens Volkmann, Barbara K. Changizi, Kathrin Doppler, Vikram Khurana   +23 more
wiley   +1 more source

Postviral olfactory dysfunction

Canadian Medical Association Journal
Akerman, Jennifer M., Munroe, Kelti M., Chin, Christopher J.   +2 more
openaire   +2 more sources

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

The Audiologic and Otolaryngologic Phenotype in WHIM Syndrome

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome) is an ultra‐rare primary immunodeficiency disease caused by autosomal dominant hyperfunctional mutations in the chemokine receptor CXCR4. Otolaryngologists are frequently consulted to evaluate WHIM patients because of recurrent acute ear and sinus ...
Christopher K. Zalewski, H. Jeffrey Kim, Carmen C. Brewer, Sophia Martinez, Caroline Rieger, Elena Cho, David H. McDermott, Philip M. Murphy   +7 more
wiley   +1 more source

Effects of Minority Status on Sensory Outcomes, Cognition, and Depression

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the association between minority status and sensory function, sleep quality, depressive symptoms, and cognitive performance in an aging population. Study Design Prospective, cross‐sectional study. Setting Participants were recruited from the Department of Otolaryngology and the Center for Cognitive Neuroscience and Aging ...
Ivette Cejas, Jennifer Coto, Aria Nawab, Alberto Cruz, Sandra Velandia, Pawan Pathagamage, Molly Smeal, Rosie C. Cid, David Loewenstein, Xue Z. Liu   +9 more
wiley   +1 more source

The Associations Between Olfactory Bulb Morphology, Volume Change, and Olfactory Recovery

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate whether olfactory bulb (OB) morphology is associated with olfactory recovery following olfactory training (OT) in individuals with COVID‐19‐related smell loss. Study Design Prospective observational study. Setting University hospital and research center.
Zetian Li, Julia Gebler, Shubin Li, Kwangsu Kim, Akshita Joshi, Xinni Xu, Antje Haehner, Vittoria Avaro, Federico Calegari, Thomas Hummel   +9 more
wiley   +1 more source

Association of Nasal Anatomy, Airflow, and Surgery With Olfactory Outcomes: A State‐of‐the‐Art Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Olfactory function is influenced by nasal airflow dynamics and anatomical variations within the nasal cavity. This narrative review evaluates how nasal anatomy and airflow relate to olfactory outcomes, with a particular focus on olfactory changes following functional nasal surgery. Data Sources PubMed.
Joshua Ferreira, Alfonso Luca Pendolino, Riccardo Pappalardo, Peter J. Andrews   +3 more
wiley   +1 more source

Questionnaires Measuring The Impact Of Olfactory Dysfunction On Quality Of Life – A Mini Review [PDF]

Olfactory dysfunction is perceived as a symptom that affects cognition, perception, emotional state, and behaviour, and has a huge impact on the patient's quality of life.
Mihaylova, Silvia; Medical College, Medical University of Varna, Bulgaria, Stamova, Sylvia; Department of Pharmaceutical chemistry, Faculty of Pharmacy, Medical University of Varna, Varna, Bulgaria, Georgieva, Emilia; Medical College, Medical University of Varna, Bulgaria, Dimitrova, Dimana; Medical College, Medical University of Varna, Bulgaria, Ermenlieva, Neli; Department of Microbiology and Virology, Faculty of Medicine, Medical University of Varna, Bulgaria, Tsvetkova, Antoaneta; Medical College, Medical University of Varna, Bulgaria, Milkov, Mario; Department of Dental Material Science and Propaedeutics of Prosthetic Dental Medicine, Faculty of Dental Medicine, Medical University of Varna, Bulgaria   +6 more
core  

Salidroside Alleviates AlCl3/D‐galactose‐Induced Alzheimer's Disease‐Like Mice Neuronal Damage and Synaptic Dysfunction Through Keap1/Nrf2/GSH Signaling Axis

Phytotherapy Research, EarlyView.
Salidroside alleviates AlCl3/D‐galactose‐induced neuronal injury and synaptic dysfunction in AD‐like mice via regulation of the Keap1/Nrf2/GSH signaling axis. ABSTRACT Alzheimer's disease (AD) is associated with glutathione (GSH) depletion and redox imbalance in the brain, contributing to hippocampal neuronal damage and synaptic dysfunction and ...
Heying Cui, Yihua Han, Yanzhu Lu, Shuhua Zheng, Ruijing Zhang, Xianjing Zhang, Zheng Nan, Xiangdan Li, Songbiao Cui, Dongyuan Xu   +9 more
wiley   +1 more source