Results 131 to 140 of about 653,353 (249)

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

SpaceNet: Pathology‐guided analysis of lesion‐associated spatial molecular programs

iMetaOmics, EarlyView.
Disease‐associated molecular alterations are often confined to localized pathological regions, yet current spatial transcriptomic analyses do not always use pathology or imaging information as the primary reference for defining disease‐relevant spatial contexts.
Menglei Wang, Qikun Zhao, Hudong Bao, Kaiyu Jin, Xiaohui Fan, Jie Liao   +5 more
wiley   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Limbic Structural Alterations and Structural Covariance Across Prodromal Phenotypes and Early Parkinson's Disease

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Non‐motor symptoms may precede motor diagnosis in Parkinson's disease (PD), but whether distinct prodromal phenotypes exhibit differential limbic structural alterations remains unclear. Purpose To investigate limbic structural alterations across prodromal PD phenotypes defined by rapid eye movement sleep behavior disorder (RBD) and ...
Yuanyuan Zhao, Luoyu Wang, Yihan Suo, Maoling Liu, Yi Lin, Lidan Fang, Zhongxiang Ding   +6 more
wiley   +1 more source

Olfactory bulb volume in the clinical assessment of olfactory dysfunction.

, 2009
The olfactory bulb collects the sensory afferents of the olfactory receptor cells located in the olfactory neuroepithelium. The olfactory bulb ends with the olfactory tract and is closely related to the olfactory sulcus of the frontal lobe.
Rombaux, Philippe, Duprez, Thierry, Hummel, T   +2 more
core  

Health risk assessment of heavy metal accumulation in fruits exposed to geothermal waters: a case study and global implications

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study investigated the potential health risks of heavy metals (HMs) in the fruits and leaves of mulberry and sour cherry trees exposed to water from Sivas geothermal basin (Turkey). RESULTS The target HMs were ranked according to their hazard index as: Cd < Pb < Zn < Cu < Ni < Mn < Cr. The total hazard index for mulberry
E Işıl Arslan Topal, Murat Topal, Erdal Çelik, Erdal Öbek   +3 more
wiley   +1 more source

Effect of myrtle aromatization on chemical profile, sensory perception, and bioactivity of white wine vinegar

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background Vinegar is a popular sour condiment rich in nutrients and bioactive components. Individual sour responsiveness greatly affects vinegar acceptance and diet consumption. In this study, the effect of aromatization with myrtle (Myrtus communis), a health‐beneficial Mediterranean aromatic plant, on the chemical composition, sensory ...
Antonella Rosa, Franca Piras, Flaminia Cesare Marincola, Valeria Sogos, Carla Masala   +4 more
wiley   +1 more source

Analysis of factors potentially associated with olfactory dysfunction and tinnitus (n = 12,618).

, 2018
Analysis of factors potentially associated with olfactory dysfunction and tinnitus (n = 12,618).
Jae Yong Lee (1854661), Chang-Hoon Kim (491637), Hyun Jun Kim (5056640), Ji Ho Choi (782575), Kyungdo Han (507253), Do-Yang Park (5884007)   +5 more
core   +1 more source

Orbital Lymphatic Malformations Are Associated With Intracranial Vascular Anomalies

The Laryngoscope, EarlyView.
In this retrospective series, all seven patients with orbital lymphatic malformations had intracranial vascular anomalies consistent with cerebrofacial venous metameric syndrome and hotspot PIK3CA variants identified through tissue‐based sequencing. Five patients treated with alpelisib experienced symptom improvement within 6 months.
Kelsey A. Loy, Jennifer Siu, Clare Richardson, J. Nathaniel Perkins, Kaitlyn Zenner, Kevin Koo, Francisco Perez, James Bennett, Randall Bly, Danial K. Hallam, Amy Geddis, Jonathan A. Perkins   +11 more
wiley   +1 more source

Management of post-infectious olfactory dysfunction: a nationwide survey of UK ENT consultants

B-ENT, 2009
Management of post-infectious olfactory dysfunction: a nationwide survey of UK ENT consultants. Objective: To determine the current practice of UK ENT consultants in investigating cases of suspected post-infectious olfactory dysfunction.
G. S. Williams, K. Ramachandran, L. Nall, J. Fong, J. Mathews   +4 more
doaj   +2 more sources