Results 51 to 60 of about 651,721 (297)

Olfactory dysfunction and the role of stem cells in the regeneration of olfactory neurons

Heliyon
The prevalence of COVID-19 has drawn increasing attention to olfactory dysfunction among researchers. Olfactory dysfunction manifests in various clinical types, influenced by numerous pathogenic factors.
Pengju Yu, Weiguan Chen, Ling Jiang, Yufeng Jia, Xiaoyan Xu, Weiye Shen, Ni Jin, Hongjie Du   +7 more
doaj   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Olfactory Evaluation in Alzheimer’s Disease Model Mice

Brain Sciences, 2022
Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer’s disease (AD). Because the olfactory system is highly conserved across species, mouse models corresponding to various AD etiologies have been bred and used in numerous studies on
Jingjing Zhang, Zixuan Zhao, Siqi Sun, Jing Li, Yu Wang, Jingyin Dong, Su Yang, Yiyi Lou, Jing Yang, Weiyun Li, Shanshan Li   +10 more
doaj   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Impairment of quality of life due to COVID-19-induced long-term olfactory dysfunction

Frontiers in Psychology, 2023
IntroductionOlfactory dysfunction is one of many long-lasting symptoms associated with COVID-19, estimated to affect approximately 60% of individuals and often lasting several months after infection.
Anja L. Winter, Sofie Henecke, Johan N. Lundström, Johan N. Lundström, Johan N. Lundström, Evelina Thunell, Evelina Thunell   +6 more
doaj   +1 more source

Position paper on olfactory dysfunction: 2023 [PDF]

, 2023
Background: Since publication of the original Position Paper on Olfactory Dysfunction in 2017 (PPOD-17), the personal and societal burden of olfactory disorders has come sharply into focus through the lens of the COVID-19 pandemic. Clinicians, scientists
Husain S, Wormald PJ, Ottaviano G, Hopkins C, Kobayashi M, Huart C, Mueller CA, Welge-Luessen A, Gane S, Douglas R, Gupta N, Haehner A, Miwa T, Schlosser RJ, Fornazieri MA, Altundag A, Ramakrishnan VR, Hsieh JW, Mazal PP, Frasnelli J, Patel ZM, Pinto JM, Van Gerven L, Vodicka J, Landis BN, Enecilla MLB, Kim JK, Konstantinidis I, Mori E, Fjaeldstad AW, Mullol J, Lechner M, Whitcroft KL, Hernandez AK, Balungwe P, Philpott C, Gudziol H, Holbrook EH, Roth Y, Hummel T., Kamel R, Macchi A, Stjärne P, Boscolo-Rizzo P, Miri I   +44 more
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Olfactory Dysfunction in Familial and Sporadic Parkinson's Disease

Frontiers in Neurology, 2020
This minireview discusses our current understanding of the olfactory dysfunction that is frequently observed in sporadic and familial forms of Parkinson's disease and parkinsonian syndromes.
Bruce A. Chase, Katerina Markopoulou, Katerina Markopoulou   +2 more
doaj   +1 more source

Non-sinonasal-related olfactory dysfunction: A cohort of 496 patients [PDF]

, 2014
INTRODUCTION AND AIM: There is a high prevalence of olfactory dysfunction in the general population. Several causes of olfactory dysfunction have been reported and this disorder is classically divided into sinonasal and non-sinonasal-related olfactory ...
Huart, C., Fonteyn, Sophie, Rombaux, Philippe, Rombaux, P., Collet, Stéphanie, Deggouj, N., Deggouj, Naima, Fonteyn, S., Eloy, P., Eloy, Philippe, Huart, Caroline, Collet, S.   +11 more
core   +1 more source

Olfactory Dysfunction in Parkinson’s Disease [PDF]

Neurosignals, 2007
Prior to the onset of the cardinal motor features of idiopathic Parkinson's disease (PD), other manifestations of neurodegeneration such as olfactory dysfunction are often apparent. Characterizing these potential biomarkers of preclinical PD is particularly important in identifying individuals who will go on to develop disabling symptoms, and thus be ...
Sarah M, Kranick, John E, Duda
openaire   +2 more sources