Results 51 to 60 of about 653,353 (249)
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Olfactory dysfunction at six months after coronavirus disease 2019 infection [PDF]
, 2021 Objective: This study aimed to assess olfactory dysfunction in patients at six months after confirmed coronavirus disease 2019 infection. Methods: Coronavirus disease 2019 positive patients were assessed six months following diagnosis.
D\u27Aulerio, G V +8 more
core +2 more sources
Higher Body Mass Index Is Associated with Subjective Olfactory Dysfunction
Behavioural Neurology, 2015 Background. Morbidly obese patients demonstrate altered olfactory acuity. There has been no study directly assessing Body Mass Index (BMI) in patients with olfactory dysfunction.
Z. M. Patel, J. M. DelGaudio, S. K. Wise
doaj +1 more source
Impairment of quality of life due to COVID-19-induced long-term olfactory dysfunction
Frontiers in Psychology, 2023 IntroductionOlfactory dysfunction is one of many long-lasting symptoms associated with COVID-19, estimated to affect approximately 60% of individuals and often lasting several months after infection.
Anja L. Winter +6 more
doaj +1 more source
Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky +5 more
wiley +1 more source
, 2016 General characteristics of participants with normal olfactory function and participants with olfactory dysfunction.
Hyo Geun Choi (668708) +5 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Olfactory Evaluation in Alzheimer’s Disease Model Mice
Brain Sciences, 2022 Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer’s disease (AD). Because the olfactory system is highly conserved across species, mouse models corresponding to various AD etiologies have been bred and used in numerous studies on
Jingjing Zhang +10 more
doaj +1 more source
Chronic Rhinosinusitis and Olfactory Dysfunction
, 2011 Chronic rhinosinusitis (CRS) is defined, according to the European Position Paper on Rhinosinusitis and Nasal Polyps , as “presence of two or more symptoms one of which should be either nasal blockage/obstruction/congestion or nasal discharge (anterior ...
Rombaux, Philippe +2 more
core +1 more source