Results 41 to 50 of about 54,861 (297)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Olfactory Dysfunction in Huntington’s Disease

Journal of Huntington's Disease, 2021
Olfactory dysfunction is a common symptom in patients with neurodegenerative disorders, including Huntington’s disease (HD). Understanding its pathophysiology is important in establishing a preventive and therapeutic plan. In this literature review, we cover the physiology of olfaction, its role in neurodegeneration, and its characteristics in patients
Patino, Jorge, Karagas, Nicholas E., Chandra, Shivika, Thakur, Nivedita, Stimming, Erin Furr   +4 more
openaire   +3 more sources

Olfactory Dysfunction in Parkinson’s Disease [PDF]

Neurosignals, 2007
Prior to the onset of the cardinal motor features of idiopathic Parkinson's disease (PD), other manifestations of neurodegeneration such as olfactory dysfunction are often apparent. Characterizing these potential biomarkers of preclinical PD is particularly important in identifying individuals who will go on to develop disabling symptoms, and thus be ...
Sarah M, Kranick, John E, Duda
openaire   +2 more sources

Olfactory dysfunction and COVID-19

Operative Techniques in Otolaryngology-Head and Neck Surgery, 2022
Here, we provide an overview of olfactory dysfunction associated with COVID-19. We provide background regarding the organization and function of the peripheral olfactory system. A review of the relevant literature on anosmia and parosmia due to infection with SARS-CoV-2, the virus causing COVID-19, is provided. Specific attention is focused on possible
Choi, Rhea, Gupta, Rupali, Finlay, John B., Goldstein, Bradley J.   +3 more
openaire   +2 more sources

Position paper on olfactory dysfunction [PDF]

Rhinology journal, 2017
Olfactory dysfunction is an increasingly recognised condition, associated with reduced quality of life and major health outcomes such as neurodegeneration and death. However, translational research in this field is limited by heterogeneity in methodological approach, including definitions of impairment, improvement and appropriate assessment techniques.
Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, Damm M, Frasnelli J, Gudziol H, Gupta N, Haehne A, Holbrook E, Hong SC, Hornung D, Hüttenbrink KB, Kamel R, Kobayashi M, Konstantinidis I, Landis BN, Leopold DA, Macchi A, Miwa T, Moesges R, Mullol J, Mueller CA, Ottaviano G, Passali GC, Philpott C, Pinto JM, Ramakrishnan VJ, Rombaux P, Roth Y, Schlosser RA, Shu B, Soler G, Stjärne P, Stuck BA, Vodicka J, Welge-Luessen A.   +38 more
openaire   +9 more sources

Impairment of quality of life due to COVID-19-induced long-term olfactory dysfunction

Frontiers in Psychology, 2023
IntroductionOlfactory dysfunction is one of many long-lasting symptoms associated with COVID-19, estimated to affect approximately 60% of individuals and often lasting several months after infection.
Anja L. Winter, Sofie Henecke, Johan N. Lundström, Johan N. Lundström, Johan N. Lundström, Evelina Thunell, Evelina Thunell   +6 more
doaj   +1 more source

Amyloid-beta Deposition and Olfactory Dysfunction in an Alzheimer's Disease Model

, 2013
Olfactory dysfunction is closely related to Alzheimer's disease (AD). Yet the mechanism behind this dysfunction remains largely unknown. To clarify the relationship between olfactory and memory deficits, we assessed behavioral and olfactory system ...
Gao, Yunling, Wu, Nan, Xu, Fuqiang, Wu, N (reprint author), Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance Atom & Mol Phys, 7 Donghu South Rd, Wuhan 430072, Peoples R China., Rao, Xiaoping, Wang, Jie   +5 more
core   +1 more source

Olfactory Evaluation in Alzheimer’s Disease Model Mice

Brain Sciences, 2022
Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer’s disease (AD). Because the olfactory system is highly conserved across species, mouse models corresponding to various AD etiologies have been bred and used in numerous studies on
Jingjing Zhang, Zixuan Zhao, Siqi Sun, Jing Li, Yu Wang, Jingyin Dong, Su Yang, Yiyi Lou, Jing Yang, Weiyun Li, Shanshan Li   +10 more
doaj   +1 more source

Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors

, 2005
Genetic perturbations of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory.
Shimshek Derya R, Mack Volker, Derya R Shimshek, Peter H Seeburg, Sprengel, Rolf, Bus, T, Mihaljevic Andre, Bus, T., Sprengel, R, Kim Jinhyun, Schaefer, AT, Mihaljevic, A, Thorsten Bus (71683), Peter H Seeburg (71687), Shimshek, DR, Rolf Sprengel (71688), Schaefer, Andreas T., Seeburg, P., Jinhyun Kim, Andre Mihaljevic, Volker Mack (71686), Mihaljevic, André, Shimshek, Derya R., Derya R Shimshek (71682), Bus, Thorsten, Seeburg, Peter H., Rolf Sprengel, Kim, Jinhyun, Mack, V, Schaefer, A., Bus Thorsten, Schaefer Andreas T, Jinhyun Kim (71684), Kim, J, Seeburg Peter H, Seeburg, PH, Kim, J., Thorsten Bus, Andreas T Schaefer, Shimshek, D., Mack, Volker, Sprengel Rolf, Mack, V., Andre Mihaljevic (71685), Volker Mack, Mihaljevic, A., Sprengel, R., Andreas T Schaefer (71689)   +47 more
core   +1 more source

Olfactory Dysfunction in Familial and Sporadic Parkinson's Disease

Frontiers in Neurology, 2020
This minireview discusses our current understanding of the olfactory dysfunction that is frequently observed in sporadic and familial forms of Parkinson's disease and parkinsonian syndromes.
Bruce A. Chase, Katerina Markopoulou, Katerina Markopoulou   +2 more
doaj   +1 more source