Results 71 to 80 of about 653,353 (249)

Hydrogen gas and olfactory dysfunction in Alzheimer’s disease: the Hydrogen–Olfactory–Limbic hypothesis

Frontiers in Aging Neuroscience
Olfactory dysfunction is increasingly recognized as an early clinical feature of Alzheimer’s disease (AD), often preceding measurable cognitive impairment and associated with subsequent cognitive decline.
Ligao Bao, Dunfu Eer
doaj   +1 more source

Olfactory Dysfunction Is Associated with the Intake of Macronutrients in Korean Adults. [PDF]

PLoS ONE, 2016
Olfactory function can impact food selection. However, few large population-based studies have investigated this effect across different age groups.
Il Gyu Kong, So Young Kim, Min-Su Kim, Bumjung Park, Jin-Hwan Kim, Hyo Geun Choi   +5 more
doaj   +1 more source

Olfactory Dysfunction in COVID-19 Patients Who Do Not Report Olfactory Symptoms: A Pilot Study with Some Suggestions for Dentists [PDF]

, 2022
Background: Smell and taste dysfunction are frequently reported by SARS-CoV-2 positive patients. The degree of olfactory and gustatory dysfunction varies from a very mild reduction to their complete loss.
Bruno Scarpa, Favero, Lorenzo, Mucignat-Caretta, Carla, Favero, Riccardo, Ottaviano, Giancarlo, Lorenzo Favero, Scarpa, Bruno, Giancarlo Ottaviano, Riccardo Favero, Gaudioso, Piergiorgio, Anna Bordin, Carla Mucignat-Caretta, Piergiorgio Gaudioso, Hajrulla, Silva, Bordin, Anna, Silva Hajrulla   +15 more
core   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

How to measure olfactory bulb volume and olfactory sulcus depth?

B-ENT, 2009
How to measure olfactory bulb volume and olfactory sulcus depth. In combination with psychophysical testing and electrophysiological studies, magnetic resonance imaging plays a role in the clinical evaluation of patients with an olfactory dysfunction ...
P. Rombaux, C. Grandin, T. Duprez
doaj   +2 more sources

Olfactory dysfunction in Wegener's granulomatosis

Rhinology journal, 2009
Necrotizing granulomatous inflammation of the upper respiratory tract is one of the hallmarks of Wegener's granulomatosis (WG), which may explain the reason for olfactory dysfunction in WG. However, a systematic analysis using modem olfactory testing tools has not been performed and potential causes of dysfunction at different levels of olfactory ...
M, Laudien, P, Lamprecht, J, Hedderich, J, Holle, P, Ambrosch   +4 more
openaire   +3 more sources

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Olfactory dysfunction in chronic stroke patients [PDF]

, 2015
Background: The aim of the study was to investigate odor identification performance in patients one year after hospital admittance due to stroke. Predictors for olfactory dysfunction were investigated as well as self-reported olfactory function and ...
Nordin, Steven,, Næss, Halvor, Eike Wehling, Hofstad, Hakon, Nordin, Steven, Håkon Hofstad, Wehling, Eike, Bende, Mats, Daniel Wollschlaeger, Wollschlaeger, Daniel, Bramerson, Annika, Halvor Naess, Mats Bende, Annika Bramerson, Naess, Halvor, Steven Nordin   +15 more
core   +2 more sources

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source