Results 81 to 90 of about 651,721 (297)

An Olfactory Receptor Pseudogene whose Function emerged in Humans [PDF]

, 2007
Human olfactory receptor, hOR17-210, is identified as a pseudogene in the human genome. Experimental data has shown however, that the gene product of cloned hOR17-210 cDNA was able to bind an odorant-binding protein and is narrowly tuned for excitation ...
Gautam Bahl, Valery Matarazzo, Chiquito J. Crasto, Peter Lai, Olivier Clot-Faybesse, Catherine Ronin, Maryse Gremigni   +6 more
core   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Chronic Rhinosinusitis and Olfactory Dysfunction

, 2011
Chronic rhinosinusitis (CRS) is defined, according to the European Position Paper on Rhinosinusitis and Nasal Polyps , as “presence of two or more symptoms one of which should be either nasal blockage/obstruction/congestion or nasal discharge (anterior ...
Rombaux, Philippe, Huart, Caroline, Franceschi, Daniel   +2 more
core   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

Advanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu, Jianbo Zhao, Zhenli Xie, Yuan Wang, Ruolin Wang, Bianbian Wang, Chuhan Shen, Yali Chen, Jingyu Yao, Ziyang Li, Huadong Xu, Zuying Chai, Zhuoyu Zhang, Changhe Wang, Rong Huang   +14 more
wiley   +1 more source

Analysis of risk factors affecting olfactory dysfunction in patients with chronic rhinosinusitis: Highlighting the role of metabolic syndrome

Laryngoscope Investigative Otolaryngology, 2023
Objective This study aims to evaluate the relationship between chronic sinusitis (CRS) and metabolic syndrome (MS) in a Chinese population and to explore the risk factors for olfactory dysfunction in patients with CRS. Methods A total of 387 CRS patients
Ling Zhang, Tao Wang, Zhu Wang, Haifeng Li, Yang Wu, Siquan Guo, Wenjing Li, Jianqiang You, Changjiang Chao   +8 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Prevalence and Outcome of Olfactory Dysfunction in COVID-19 Patients in a Multiracial Asian Setting

B-ENT, 2022
Objective: This study aimed to outline the prevalence and the outcome of olfactory dysfunction in a multiracial Asian setting. Methods: The olfactory function of adult patients (above 18 years of age) who tested positive for coronavirus disease 2019 via ...
Jeyasakthy Saniasiaya, Nurul Asma Che Ab Rahim, Carren Sui-Lin Teh, Narayanan Prepageran   +3 more
doaj   +2 more sources

Olfactory dysfunction associated with Neuro-Behcet disease [PDF]

, 2017
WOS: 000417057300044PubMed ID: 28863008Introduction: Neurologic involvement associated with Behcet disease (BD) is defined as a different entity: Neuro-Behcet disease (NBD). Behcet disease presents with olfactory dysfunction. It is not known whether this
Ertaş, Burak, Veyseller, Bayram, Remzi Doğan, Özüçer, Berke, Birday, Erkingül, Berke Özücer, Bayram Veyseller, Erkingul Birday, Burak Ertaş, Doğan, Remzi, Orhan Özturan, Özturan, Orhan   +11 more
core   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source