Results 1 to 10 of about 1,587 (178)

Generation of functional neurons from adult human mucosal olfactory ensheathing glia by direct lineage conversion [PDF]

Cell Death and Disease, 2023
A recent approach to promote central nervous system (CNS) regeneration after injury or disease is direct conversion of somatic cells to neurons. This is achieved by transduction of viral vectors that express neurogenic transcription factors. In this work
María Portela-Lomba, Diana Simón, Marta Callejo-Móstoles, Gemma de la Fuente, David Fernández de Sevilla, Vega García-Escudero, M. Teresa Moreno-Flores, Javier Sierra   +7 more
doaj   +6 more sources

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia: a double-edged sword [PDF]

Neural Regeneration Research
Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system, including retinal ganglion cell axonal growth through the injured optic nerve.
María Norte-Muñoz, María Portela-Lomba, Paloma Sobrado-Calvo, Diana Simón, Johnny Di Pierdomenico, Alejandro Gallego-Ortega, Mar Pérez, José M. Cabrera-Maqueda, Javier Sierra, Manuel Vidal-Sanz, María Teresa Moreno-Flores, Marta Agudo-Barriuso   +11 more
doaj   +3 more sources

Olfactory ensheathing glia express aquaporin 1. [PDF]

J Comp Neurol, 2010
AbstractOlfactory ensheathing glia (OEG) are distinct from other glia in their developmental origin, presence in both the peripheral and central nervous systems, and highly restricted location. OEG are present only in the olfactory lamina propria, olfactory nerve, and the outer two layers of the olfactory bulb, where they envelop bundles of olfactory ...
Shields SD, Moore KD, Phelps PE, Basbaum AI.   +3 more
europepmc   +6 more sources

Small molecules fail to induce direct reprogramming of adult rat olfactory ensheathing glia to mature neurons [PDF]

Frontiers in Molecular Neuroscience, 2023
An approach to generate new neurons after central nervous system injury or disease is direct reprogramming of the individual's own somatic cells into differentiated neurons.
María Portela-Lomba, Diana Simón, David Fernández de Sevilla, Mª Teresa Moreno-Flores, Javier Sierra, Javier Sierra   +5 more
doaj   +4 more sources

Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair [PDF]

eLife, 2023
Olfactory ensheathing cells (OECs) are unique glial cells found in both central and peripheral nervous systems where they support continuous axonal outgrowth of olfactory sensory neurons to their targets.
Patricia E Phelps, Sung Min Ha, Rana R Khankan, Mahlet A Mekonnen, Giovanni Juarez, Kaitlin L Ingraham Dixie, Yen-Wei Chen, Xia Yang   +7 more
doaj   +7 more sources

Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium [PDF]

Frontiers in Cellular Neuroscience, 2023
The endocannabinoid system (ECS) refers to a complex cell-signaling system highly conserved among species formed by numerous receptors, lipid mediators (endocannabinoids) and synthetic and degradative enzymes. It is widely distributed throughout the body
Yolanda Paes-Colli, Priscila M. P. Trindade, Louise C. Vitorino, Fabiana Piscitelli, Fabio Arturo Iannotti, Raquel M. P. Campos, Alinny R. Isaac, Andrey Fabiano Lourenço de Aguiar, Silvana Allodi, Fernando G. de Mello, Marcelo Einicker-Lamas, Raphael de Siqueira-Santos, Vincenzo Di Marzo, Vincenzo Di Marzo, Bakhos A. Tannous, Bakhos A. Tannous, Litia A. Carvalho, Litia A. Carvalho, Ricardo A. De Melo Reis, Luzia S. Sampaio   +19 more
doaj   +4 more sources

Mouse olfactory ensheathing glia enhance axon outgrowth on a myelin substrate in vitro. [PDF]

Exp Neurol, 2009
Olfactory ensheathing glia (OEG) express cell adhesion molecules and secrete growth factors that support newly generated olfactory axons and are a promising therapeutic treatment to facilitate axonal regeneration after spinal cord injury (SCI). To study the molecular mechanisms underlying the ability of OEG to enhance axonal outgrowth, we designed an ...
Runyan SA, Phelps PE.
europepmc   +6 more sources

Olfactory ensheathing glia are required for embryonic olfactory axon targeting and the migration of gonadotropin-releasing hormone neurons [PDF]

Biology Open, 2013
Summary Kallmann's syndrome is caused by the failure of olfactory axons and gonadotropin-releasing hormone (GnRH) neurons to enter the embryonic forebrain, resulting in anosmia and sterility.
Perrine Barraud, James A. St John, C. Claus Stolt, Michael Wegner, Clare V. H. Baker   +4 more
doaj   +7 more sources

Olfactory ensheathing cells for spinal cord repair: crucial differences between subpopulations of the glia

Neural Regeneration Research, 2015
OECs for spinal cord repair: Is repairing the injured spinal cord by olfactory ensheathing cell (OEC) transplantation possible? A recent human trial in which a paralysed man regained some function after transplantation of partially purified OECs suggests that this therapy may be a successful approach (Tabakow et al., 2014).
Jenny A.K. Ekberg, James A St John
doaj   +5 more sources

Neural crest origin of olfactory ensheathing glia. [PDF]

Proc Natl Acad Sci U S A, 2010
Olfactory ensheathing cells (OECs) are a unique class of glial cells with exceptional translational potential because of their ability to support axon regeneration in the central nervous system. Although OECs are similar in many ways to immature and nonmyelinating Schwann cells, and can myelinate large-diameter axons indistinguishably from myelination ...
Barraud P, Seferiadis AA, Tyson LD, Zwart MF, Szabo-Rogers HL, Ruhrberg C, Liu KJ, Baker CV.   +7 more
europepmc   +6 more sources