Results 141 to 150 of about 1,587 (178)

Olfactory ensheathing glia injections in Beijing: Misleading patients with ALS

Amyotrophic Lateral Sclerosis, 2007
Different forms of cell transplantation therapy are being tested in models of ALS. While the approach offers hope to patients with ALS, much still needs to be learned in the laboratory before it is ready for human trials. Nevertheless, clinics across the world offer various types of open label cell transplantation therapy for high fees.
Sheena, Chew, Alexander G, Khandji, Jacqueline, Montes, Hiroshi, Mitsumoto, Paul H, Gordon   +4 more
openaire   +2 more sources

Olfactory ensheathing glia: Repairing injury to the mammalian visual system

Experimental Neurology, 2011
The visual system is widely used as a model in which to study neurotrauma of the central nervous system and to assess the effects of experimental therapies. Adult mammalian retinal ganglion cell axons do not normally regenerate their axons for long distances following injury.
Giles W, Plant, Alan R, Harvey, Simone G, Leaver, Seok Voon, Lee   +3 more
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Comparative gene expression profiling of olfactory ensheathing glia and Schwann cells indicates distinct tissue repair characteristics of olfactory ensheathing glia

Glia, 2008
AbstractOlfactory ensheathing glia (OEG) are a specialized type of glia that support the growth of primary olfactory axons from the neuroepithelium in the nasal cavity to the brain. Transplantation of OEG in the injured spinal cord promotes sprouting of injured axons and results in reduced cavity formation, enhanced axonal and tissue sparing ...
Franssen, E.H.P., de Bree, F.M., Essing, A.H.W., Ramon-Cueto, A., Verhaagen, J.   +4 more
openaire   +2 more sources

Culturing Olfactory Ensheathing Glia from the Mouse Olfactory Epithelium

2003
Olfactory ensheathing cells (OECs) are not a class of stem cell, but they are a specialized and highly plastic glial cell that can continuously support the neurogenesis and axonal regeneration of olfactory receptor neurons. Because of this, they have been transplanted into sites of spinal cord injury to test their efficacy in promoting repair.
Edmund, Au, A Jane, Roskams
openaire   +2 more sources

Culture conditions affect proliferative responsiveness of olfactory ensheathing glia to neuregulins

Glia, 2007
AbstractOlfactory ensheathing glia (OEG) have been used to improve outcome after experimental spinal cord injury and are being trialed clinically. Their rapid proliferation in vitro is essential to optimize clinical application, with neuregulins (NRG) being potential mitogens.
T R, De Mello, S, Busfield, S A, Dunlop, G W, Plant   +3 more
openaire   +2 more sources

Olfactory ensheathing glia and Schwann cells: two of a kind?

Cell and Tissue Research, 2002
Both olfactory ensheathing cells (OECs) and Schwann cells have been shown to promote axonal regrowth and remyelination in the central (CNS) and peripheral nervous systems under experimental conditions. During development, OECs and Schwann cells emerge from the olfactory placode and the neural crest, respectively, thus sharing a common "peripheral ...
Konstantin, Wewetzer, Enrique, Verdú, Doychin N, Angelov, Xavier, Navarro   +3 more
openaire   +2 more sources

Mitogenic response of adult rat olfactory ensheathing glia to four growth factors

Glia, 2001
Olfactory ensheathing glia (EG) from adult rat proliferate slowly in vitro without added mitogens. The potential future use of EG in transplantation within the central nervous system to improve neural repair is dependent on identifying mitogens that will effectively expand EG without altering their phenotype.
H, Yan, M B, Bunge, P M, Wood, G W, Plant   +3 more
openaire   +2 more sources

Clinical application of adult olfactory bulb ensheathing glia for nervous system repair

Experimental Neurology, 2011
The ability of adult olfactory bulb ensheathing glia (OB-OEG) to promote histological and functional neural repair has been broadly documented. Pre-clinical studies show that beneficial effects of adult OB-OEG are repeatable in the same type of spinal cord injury initially tested, in other spinal cord and CNS injury models, in different species and ...
Almudena, Ramón-Cueto, Cintia, Muñoz-Quiles   +1 more
openaire   +2 more sources

Axon‐glia communication evokes calcium signaling in olfactory ensheathing cells of the developing olfactory bulb

Glia, 2006
AbstractOlfactory ensheathing cells (OECs) accompany receptor axons in the olfactory nerve and promote axonal growth into the central nervous system. The mechanisms underlying the communication between axons and OECs, however, have not been studied in detail yet.
Anne, Rieger, Joachim W, Deitmer, Christian, Lohr   +2 more
openaire   +2 more sources

Olfactory ensheathing glia: Their contribution to primary olfactory nervous system regeneration and their regenerative potential following transplantation into the injured spinal cord

Brain Research Reviews, 2007
Olfactory ensheathing glia (OEG) are a specialized type of glia that guide primary olfactory axons from the neuroepithelium in the nasal cavity to the brain. The primary olfactory system is able to regenerate after a lesion and OEG contribute to this process by providing a growth-supportive environment for newly formed axons.
Franssen, Elske H P, de Bree, Freddy M, Verhaagen, J.   +2 more
openaire   +2 more sources