Results 141 to 150 of about 4,174 (181)

Olfactory ensheathing glia injections in Beijing: Misleading patients with ALS

Amyotrophic Lateral Sclerosis, 2007
Different forms of cell transplantation therapy are being tested in models of ALS. While the approach offers hope to patients with ALS, much still needs to be learned in the laboratory before it is ready for human trials. Nevertheless, clinics across the world offer various types of open label cell transplantation therapy for high fees.
Hiroshi Mitsumoto, Jacqueline Montes, Paul H. Gordon, Sheena Chew, Alexander G. Khandji   +4 more
openaire   +3 more sources

Olfactory ensheathing glia: Repairing injury to the mammalian visual system

Experimental Neurology, 2011
The visual system is widely used as a model in which to study neurotrauma of the central nervous system and to assess the effects of experimental therapies. Adult mammalian retinal ganglion cell axons do not normally regenerate their axons for long distances following injury.
Seok Voon Lee, Seok Voon Lee, Simone G. Leaver, Alan R. Harvey, Giles W. Plant, Giles W. Plant   +5 more
openaire   +3 more sources

Comparative gene expression profiling of olfactory ensheathing glia and Schwann cells indicates distinct tissue repair characteristics of olfactory ensheathing glia

Glia, 2008
AbstractOlfactory ensheathing glia (OEG) are a specialized type of glia that support the growth of primary olfactory axons from the neuroepithelium in the nasal cavity to the brain. Transplantation of OEG in the injured spinal cord promotes sprouting of injured axons and results in reduced cavity formation, enhanced axonal and tissue sparing ...
Almudena Ramón-Cueto, Freddy M. de Bree, Joost Verhaagen, Elske H. P. Franssen, Anke H. W. Essing   +4 more
openaire   +3 more sources

Culture conditions affect proliferative responsiveness of olfactory ensheathing glia to neuregulins

Glia, 2007
AbstractOlfactory ensheathing glia (OEG) have been used to improve outcome after experimental spinal cord injury and are being trialed clinically. Their rapid proliferation in vitro is essential to optimize clinical application, with neuregulins (NRG) being potential mitogens.
Samantha J. Busfield, Giles W. Plant, Sarah A. Dunlop, T.R. De Mello   +3 more
openaire   +3 more sources

Culturing Olfactory Ensheathing Glia from the Mouse Olfactory Epithelium

2003
Olfactory ensheathing cells (OECs) are not a class of stem cell, but they are a specialized and highly plastic glial cell that can continuously support the neurogenesis and axonal regeneration of olfactory receptor neurons. Because of this, they have been transplanted into sites of spinal cord injury to test their efficacy in promoting repair.
Edmund Au, A. Jane Roskams
openaire   +3 more sources

Sphingosine 1‐phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer

Glia, 2020
Olfactory ensheathing cells (OECs) are unique glial cells with axonal growth‐promoting properties in the olfactory epithelium and olfactory bulb, covering the entire length of the olfactory nerve.
Xiao-mei Bao, Xingxing Xu, Qian Wu, Jingjing Zhang, W. Feng, Danlu Yang, Fayi Li, Sheng Lu, Huitao Liu, Xiya Shen, Fan Zhang, Changnan Xie, Shiyang Wu, Zhaoting Lv, Wei Wang, Hongjuan Li, Yuan-yuan Fang, Ying Wang, Honglin Teng, Zhihui Huang   +19 more
semanticscholar   +1 more source

Axon‐glia communication evokes calcium signaling in olfactory ensheathing cells of the developing olfactory bulb

Glia, 2006
AbstractOlfactory ensheathing cells (OECs) accompany receptor axons in the olfactory nerve and promote axonal growth into the central nervous system. The mechanisms underlying the communication between axons and OECs, however, have not been studied in detail yet.
Christian Lohr, Anne Rieger, Joachim W. Deitmer   +2 more
openaire   +3 more sources

Telomerase protects adult rodent olfactory ensheathing glia from early senescence

Experimental Neurology, 2011
Adult olfactory bulb ensheathing glia (OB-OEG) promote the repair of acute, subacute, and chronic spinal cord injuries and autologous transplantation is a feasible approach. There are interspecies differences between adult rodent and primate OB-OEG related to their longevity in culture.
Almudena Ramón-Cueto, Mari-Paz Rubio, María-Beatriz Llamusí   +2 more
openaire   +2 more sources

Mitogenic response of adult rat olfactory ensheathing glia to four growth factors

Glia, 2001
Olfactory ensheathing glia (EG) from adult rat proliferate slowly in vitro without added mitogens. The potential future use of EG in transplantation within the central nervous system to improve neural repair is dependent on identifying mitogens that will effectively expand EG without altering their phenotype.
Giles W. Plant, Henglin Yan, Mary Bartlett Bunge, Patrick M. Wood   +3 more
openaire   +3 more sources

Clinical application of adult olfactory bulb ensheathing glia for nervous system repair

Experimental Neurology, 2011
The ability of adult olfactory bulb ensheathing glia (OB-OEG) to promote histological and functional neural repair has been broadly documented. Pre-clinical studies show that beneficial effects of adult OB-OEG are repeatable in the same type of spinal cord injury initially tested, in other spinal cord and CNS injury models, in different species and ...
Cintia Muñoz-Quiles, Almudena Ramón-Cueto   +1 more
openaire   +3 more sources