Differing phagocytic capacities of accessory and main olfactory ensheathing cells and the implication for olfactory glia transplantation therapies [PDF]
Molecular and Cellular Neuroscience, 2015 The rodent olfactory systems comprise the main olfactory system for the detection of odours and the accessory olfactory system which detects pheromones. In both systems, olfactory axon fascicles are ensheathed by olfactory glia, termed olfactory ensheathing cells (OECs), which are crucial for the growth and maintenance of the olfactory nerve.
Lynn Nazareth +5 more
semanticscholar +6 more sources
Noninvasive Bioluminescence Imaging of Olfactory Ensheathing Glia and Schwann Cells following Transplantation into the Lesioned Rat Spinal Cord [PDF]
Cell Transplantation, 2012 In this study, we assess the feasibility of bioluminescence imaging to monitor the survival of Schwann cells (SCs) and olfactory ensheathing glia cells (OECs) after implantation in the lesioned spinal cord of adult rats.
Kasper C. D. Roet M.Sc. +2 more
doaj +3 more sources
Mouse olfactory ensheathing glia enhance axon outgrowth on a myelin substrate in vitro. [PDF]
Exp Neurol, 2009 Olfactory ensheathing glia (OEG) express cell adhesion molecules and secrete growth factors that support newly generated olfactory axons and are a promising therapeutic treatment to facilitate axonal regeneration after spinal cord injury (SCI). To study the molecular mechanisms underlying the ability of OEG to enhance axonal outgrowth, we designed an ...
Runyan SA, Phelps PE.
europepmc +6 more sources
Further evidence of olfactory ensheathing glia facilitating axonal regeneration after a complete spinal cord transection. [PDF]
Exp Neurol, 2011 Spinal Wistar Hannover rats injected with olfactory ensheathing glia (OEG) have been shown to recover some bipedal stepping and climbing abilities. Given the intrinsic ability of the spinal cord to regain stepping with pharmacological agents or epidural stimulation after a complete mid-thoracic transection, we asked if functional recovery after OEG ...
Ziegler MD +7 more
europepmc +7 more sources
Axon regeneration can facilitate or suppress hindlimb function after olfactory ensheathing glia transplantation. [PDF]
J Neurosci, 2011 Reports based primarily on anatomical evidence suggest that olfactory ensheathing glia (OEG) transplantation promotes axon regeneration across a complete spinal cord transection in adult rats.
Takeoka A +11 more
europepmc +6 more sources
Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs) [PDF]
Glia, 2018 AbstractThe prospects of achieving regeneration in the central nervous system (CNS) have changed, as most recent findings indicate that several species, including humans, can produce neurons in adulthood. Studies targeting this property may be considered as potential therapeutic strategies to respond to injury or the effects of demyelinating diseases ...
R. M. Gómez +6 more
semanticscholar +6 more sources
Frontiers in Immunology, 2022 Accumulating evidence sustains glial cells as critical players during central nervous system (CNS) development, homeostasis and disease. Olfactory ensheathing cells (OECs), a type of specialized glia cells sharing properties with both Schwann cells and ...
Simona Denaro +14 more
doaj +2 more sources
Early Draper-mediated glial refinement of neuropil architecture and synapse number in the Drosophila antennal lobe [PDF]
Frontiers in Cellular Neuroscience, 2023 Glial phagocytic activity refines connectivity, though molecular mechanisms regulating this exquisitely sensitive process are incompletely defined. We developed the Drosophila antennal lobe as a model for identifying molecular mechanisms underlying glial
Darren A. Jindal +7 more
doaj +2 more sources
Abstract 3114: Olfactory ensheathing glia as a cell-based therapy for glioblastomas
Cancer Research, 2021 Introduction: Olfactory ensheathing glia (OEG) is a fully differentiated cell that promotes the continuous regeneration of odor receptors from the nasal mucosa to the olfactory bulb during adult lifespan.
Litia A. Carvalho +8 more
semanticscholar +3 more sources
Neural Regeneration Research, 2020 Transplantation of olfactory ensheathing cells, the glia of the primary olfactory nervous system, has been trialed for spinal cord injury repair with promising but variable outcomes in animals and humans.
Ronak Reshamwala +4 more
doaj +2 more sources