Results 11 to 20 of about 1,587 (178)

Early Draper-mediated glial refinement of neuropil architecture and synapse number in the Drosophila antennal lobe [PDF]

Frontiers in Cellular Neuroscience, 2023
Glial phagocytic activity refines connectivity, though molecular mechanisms regulating this exquisitely sensitive process are incompletely defined. We developed the Drosophila antennal lobe as a model for identifying molecular mechanisms underlying glial
Darren A. Jindal, Hans C. Leier, Gabriela Salazar, Alexander J. Foden, Elizabeth A. Seitz, Abigail J. Wilkov, Jaeda C. Coutinho-Budd, Heather T. Broihier   +7 more
doaj   +2 more sources

Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning. [PDF]

PLoS Biology
Synapse connectivity is optimized in response to environmental input in critical periods, characterized by experience-dependent, temporally-restricted, and transiently-reversible synapse pruning by glial phagocytes.
Vanessa Kay Miller, Kendal Broadie
doaj   +2 more sources

Glia control experience-dependent plasticity in an olfactory critical period [PDF]

eLife
Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The Drosophila antennal
Hans C Leier, Alexander J Foden, Darren A Jindal, Abigail J Wilkov, Paola Van der Linden Costello, Pamela J Vanderzalm, Jaeda Coutinho-Budd, Masashi Tabuchi, Heather T Broihier   +8 more
doaj   +2 more sources

Clinical Observation of Fetal Olfactory Ensheathing Glia Transplantation (OEGT) in Patients with Complete Chronic Spinal Cord Injury

Cell Transplantation, 2012
This study was designed to observe the functional changes after fetal olfactory ensheathing glia transplantation (OEGT) into the spinal cord of patients with chronic spinal cord injury (SCI). Patients whose recovery had plateaued for longer than 6 months
Jun Wu, Tiansheng Sun, Chaoqun Ye, Jianhua Yao, Bing Zhu, Hongying He   +5 more
doaj   +2 more sources

Olfactory Ensheathing Glia: Drivers of Axonal Regeneration in the Central Nervous System? [PDF]

BioMed Research International, 2002
Olfactory ensheathing glia (OEG) accompany olfactory growing axons in their entry to the adult mammalian central nervous system (CNS). Due to this special characteristic, considerable attention has been focused on the possibility of using OEG for CNS regeneration.
María Teresa Moreno-Flores, Javier Díaz‐Nido, Francisco Wandosell, Jesús Ávila   +3 more
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Chronic Spinal Injury Repair by Olfactory Bulb Ensheathing Glia and Feasibility for Autologous Therapy [PDF]

Journal of Neuropathology & Experimental Neurology, 2009
Olfactory bulb ensheathing glia (OB-OEG) promote repair of spinal cord injury (SCI) in rats after transplantation at acute or subacute (up to 45 days) stages. The most relevant clinical scenario in humans, however, is chronic SCI, in which no more major cellular or molecular changes occur at the injury site; this occurs after the third month in rodents.
Cintia Muñoz-Quiles, Fernando F. Santos‐Benito, Beatriz Llamusí, Almudena Ramón‐Cueto   +3 more
openalex   +4 more sources

Fibroblast Growth Factor Signaling Instructs Ensheathing Glia Wrapping of Drosophila Olfactory Glomeruli [PDF]

Proceedings of the National Academy of Sciences, 2017
AbstractThe formation of complex yet highly organized neural circuits requires interactions between neurons and glia. During the assembly of theDrosophilaolfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in the antennal lobe, each of which ...
Bing Wu, Jun Li, Ya-Hui Chou, David J. Luginbuhl, Liqun Luo   +4 more
openalex   +4 more sources

Differing phagocytic capacities of accessory and main olfactory ensheathing cells and the implication for olfactory glia transplantation therapies [PDF]

Molecular and Cellular Neuroscience, 2015
The rodent olfactory systems comprise the main olfactory system for the detection of odours and the accessory olfactory system which detects pheromones. In both systems, olfactory axon fascicles are ensheathed by olfactory glia, termed olfactory ensheathing cells (OECs), which are crucial for the growth and maintenance of the olfactory nerve.
Lynn Nazareth, Johana Tello Velasquez, Katie E. Lineburg, Fatemeh Chehrehasa, James A. St John, Jenny Ekberg   +5 more
openalex   +5 more sources

Glial cells in the mammalian olfactory bulb [PDF]

Frontiers in Cellular Neuroscience
The mammalian olfactory bulb (OB), an essential part of the olfactory system, plays a critical role in odor detection and neural processing. Historically, research has predominantly focused on the neuronal components of the OB, often overlooking the ...
Dan Zhao, Meigeng Hu, Shaolin Liu
doaj   +2 more sources

Olfactory ensheathing glia graft in combination with FK506 administration promote repair after spinal cord injury

Neurobiology of Disease, 2006
The aim of this study was to determine whether a combination of olfactory ensheathing cell (OEC) graft with the administration of FK506, two experimental approaches that have been previously reported to exert protective/regenerative effects after spinal ...
Rubèn López-Vales, Joaquim Forés, Xavier Navarro, Enrique Verdú   +3 more
doaj   +2 more sources