Results 31 to 40 of about 1,587 (178)

Reliable cell purification and determination of cell purity: crucial aspects of olfactory ensheathing cell transplantation for spinal cord repair

Neural Regeneration Research, 2020
Transplantation of olfactory ensheathing cells, the glia of the primary olfactory nervous system, has been trialed for spinal cord injury repair with promising but variable outcomes in animals and humans.
Ronak Reshamwala, Megha Shah, Lucy Belt, Jenny A. K. Ekberg, James A St John   +4 more
doaj   +1 more source

Olfactory deficits in Niemann-Pick type C1 (NPC1) disease. [PDF]

PLoS ONE, 2013
BACKGROUND: Niemann-Pick type C disease (NPC) is a rare autosomal recessive lipid storage disease characterized by progressive neurodegeneration. As only a few studies have been conducted on the impact of NPC on sensory systems, we used a mutant mouse ...
Marina Hovakimyan, Anja Meyer, Jan Lukas, Jiankai Luo, Volker Gudziol, Thomas Hummel, Arndt Rolfs, Andreas Wree, Martin Witt   +8 more
doaj   +1 more source

Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease

Frontiers in Cell and Developmental Biology, 2021
The central nervous system (CNS) has very limited capacity to regenerate after traumatic injury or disease. In contrast, the peripheral nervous system (PNS) has far greater capacity for regeneration.
Lynn Nazareth, Lynn Nazareth, James St John, James St John, James St John, Mariyam Murtaza, Mariyam Murtaza, Mariyam Murtaza, Jenny Ekberg, Jenny Ekberg, Jenny Ekberg   +10 more
doaj   +1 more source

Retroviral lineage analysis reveals dual contribution from ectodermal placodes and neural crest cells to avian olfactory sensory and GnRH neurons

Natural Sciences, 2022
The origin of the neurons and glia in the olfactory system of vertebrates has been controversial, with different cell types attributed to being of ectodermal placode versus neural crest lineage, depending upon the species.
Alison Koontz, Hugo A. Urrutia, Marianne E. Bronner   +2 more
doaj   +1 more source

The Aquaporin-4 Expression and Localization in the Olfactory Epithelium Modulate the Odorant-Evoked Responses and Olfactory-Driven Behavior. [PDF]

Glia
Main Points AQP4ex and OAP‐forming AQP4M23 are expressed in non‐neuronal cells of the olfactory epithelium. AQP4ex‐KO and OAP‐null mice show reduced cell density, including OSNs, and impaired odor responses and behavior, with AQP4ex emerging as key regulator.
Lobraico D, Abbrescia P, Fioriello MG, Barile B, Palazzo C, Valente O, Nicchia GP, Dibattista M, Frigeri A.   +8 more
europepmc   +2 more sources

Olfactory ensheathing cells in facial nerve regeneration

Brazilian Journal of Otorhinolaryngology, 2020
Introduction: Olfactory ensheathing cell is a unique kind of glia cells, which can promote axon growth. Little is known about the differences between olfactory mucosa olfactory ensheathing cells and olfactory bulb olfactory ensheathing cells in the ...
Manyi Li, Qiubei Zhu, Jisheng Liu
doaj   +1 more source

Neurotrophic and immunomodulatory effects of olfactory ensheathing cells as a strategy for neuroprotection and regeneration

Frontiers in Immunology, 2022
Accumulating evidence sustains glial cells as critical players during central nervous system (CNS) development, homeostasis and disease. Olfactory ensheathing cells (OECs), a type of specialized glia cells sharing properties with both Schwann cells and ...
Simona Denaro, Simona D’Aprile, Cristiana Alberghina, Anna Maria Pavone, Filippo Torrisi, Sebastiano Giallongo, Lucia Longhitano, Giuliana Mannino, Debora Lo Furno, Agata Zappalà, Rosario Giuffrida, Daniele Tibullo, Giovanni Li Volti, Nunzio Vicario, Rosalba Parenti   +14 more
doaj   +1 more source

Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature

Frontiers in Cellular Neuroscience, 2021
Olfactory ensheathing cells (OECs) are specialized glia cells of the olfactory system that support the continual regeneration of olfactory neurons throughout adulthood.
Mahjabeen Miah, Patrizia Ferretti, David Choi   +2 more
doaj   +1 more source

Identification and Functional Characterization of a Novel SEMA3A Exon Deletion Variant in Kallmann Syndrome. [PDF]

Mol Genet Genomic Med
The study identified a novel SEMA3A exons 6–9 deletion variant in Kallmann syndrome that impairs GnRH neuronal migration and alters cell migration, gonad development, and synaptic pathways. The study expands mutation spectrum and offers mechanistic insights for clinical diagnosis of Kallmann syndrome.
Zang S, Zhou S, Liu Q, Yin X, Li P.
europepmc   +2 more sources

Antimicrobial responses of peripheral and central nervous system glia against Staphylococcus aureus

Scientific Reports, 2021
Staphylococcus aureus infections of the central nervous system are serious and can be fatal. S. aureus is commonly present in the nasal cavity, and after injury to the nasal epithelium it can rapidly invade the brain via the olfactory nerve.
Indra N. Choudhury, Anu Chacko, Ali Delbaz, Mo Chen, Souptik Basu, James A. St John, Flavia Huygens, Jenny A. K. Ekberg   +7 more
doaj   +1 more source