Cell Transplantation, 2012 This study was designed to observe the functional changes after fetal olfactory ensheathing glia transplantation (OEGT) into the spinal cord of patients with chronic spinal cord injury (SCI). Patients whose recovery had plateaued for longer than 6 months
Jun Wu +5 more
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Olfactory ensheathing glia transplantation: A therapy to promote repair in the mammalian central nervous system [PDF]
The Anatomical Record Part B: The New Anatomist, 2003 AbstractA therapy to treat injuries to the central nervous system (CNS) is, to date, a major clinical challenge. The devastating functional consequences they cause in human patients have encouraged many scientists to search, in animal models, for a repair strategy that could, in the future, be applied to humans.
Fernando F. Santos‐Benito +1 more
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NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration [PDF]
Brain, 2005 Adenoviral (AdV) vectors encoding neurotrophin-3 (AdV-NT-3) or the bacterial marker enzyme beta-galactosidase (LacZ gene) were used to transduce olfactory ensheathing glia (OEG) cultures. AdV vector-transduced OEG expressed high levels of recombinant neurotrophin as shown by in situ hybridization and enzyme-linked immunosorbent assay techniques.
Marc J. Ruitenberg
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Motile membrane protrusions regulate cell–cell adhesion and migration of olfactory ensheathing glia [PDF]
Glia, 2007 AbstractOlfactory ensheathing cells (OECs) are candidates for therapeutic approaches for neural regeneration due to their ability to assist axon regrowth in central nervous system lesion models. However, little is understood about the processes and mechanisms underlying migration of these cells.
Louisa Windus +4 more
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The effects of peptide modified gellan gum and olfactory ensheathing glia cells on neural stem/progenitor cell fate [PDF]
Biomaterials, 2012 Nuno A. Silva +6 more
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c-AMP-mediated changes in the intracellular distribution of the myelin-related protein CNPase in olfactory ensheathing glia (OEG) [PDF]
Anais da Academia Brasileira de Ciências, 2000 ALESSANDRA SANTOS-SILVA +1 more
doaj +2 more sources
Transcriptional profiling predicts overwhelming homology of schwann cells, olfactory ensheathing cells, and schwann cell‐like glia [PDF]
Glia, 2014 Reiner Ulrich +9 more
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Olfactory deficits in Niemann-Pick type C1 (NPC1) disease. [PDF]
PLoS ONE, 2013 BACKGROUND: Niemann-Pick type C disease (NPC) is a rare autosomal recessive lipid storage disease characterized by progressive neurodegeneration. As only a few studies have been conducted on the impact of NPC on sensory systems, we used a mutant mouse ...
Marina Hovakimyan +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The central nervous system (CNS) has very limited capacity to regenerate after traumatic injury or disease. In contrast, the peripheral nervous system (PNS) has far greater capacity for regeneration.
Lynn Nazareth +10 more
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Natural Sciences, 2022 The origin of the neurons and glia in the olfactory system of vertebrates has been controversial, with different cell types attributed to being of ectodermal placode versus neural crest lineage, depending upon the species.
Alison Koontz +2 more
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