Results 51 to 60 of about 1,587 (178)
Olfactory Ensheathing Cells for Spinal Cord Injury
Cell Transplantation, 2018 Olfactory ensheathing cells (OECs) are glia reported to sustain the continuous axon extension and successful topographic targeting of the olfactory receptor neurons responsible for the sense of smell (olfaction).
R. Yao +7 more
doaj +1 more source
Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration
Frontiers in Neuroscience, 2020 The developing nervous system is a complex yet organized system of neurons, glial support cells, and extracellular matrix that arranges into an elegant, highly structured network.
Michael J. Rigby +8 more
doaj +1 more source
Journal of Integrative Neuroscience, 2023 Background: Glaucoma is the leading cause of irreversible blindness, and the loss of retinal ganglion cells (RGCs) is the most important pathological feature.
Hui Gao +5 more
doaj +1 more source
Abstract 3114: Olfactory ensheathing glia as a cell-based therapy for glioblastomas
Cancer Research, 2021 Abstract Introduction: Olfactory ensheathing glia (OEG) is a fully differentiated cell that promotes the continuous regeneration of odor receptors from the nasal mucosa to the olfactory bulb during adult lifespan. OEG secretes several factors making the environment more permissive to regeneration, and promotes differentitation of ...
Litia Carvalho +8 more
openaire +1 more source
Nerve injury promotes glial immune responses through a Draper/Ninjurin A pathway
Neurobiology of DiseaseDegenerating neurons elicit striking immune reactions from glial cells, including directed invasion of injury sites and engulfment of neuronal debris.
Cole R. Brashaw +3 more
doaj +1 more source
Olfactory Ensheathing Cells Express α7 Integrin to Mediate Their Migration on Laminin.
PLoS ONE, 2016 The unique glia located in the olfactory system, called olfactory ensheathing cells (OECs), are implicated as an attractive choice for transplantation therapy following spinal cord injury because of their pro-regenerative characteristics.
Norianne T Ingram +2 more
doaj +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Biology Open, 2017 Perivascular/mural cells originate from either the mesoderm or the cranial neural crest. Regardless of their origin, Notch signalling is necessary for their formation. Furthermore, in both chicken and mouse, constitutive Notch1 activation (via expression
Sophie R. Miller +2 more
doaj +1 more source
Adult olfactory bulbs from primates provide reliable ensheathing glia for cell therapy
Glia, 2008 AbstractOlfactory bulb ensheathing glia (OB‐OEG) from adult rodents promote functional and morphological repair after grafting into injured spinal cords. To provide insight into the feasibility of using OB‐OEG in human therapy, we studied OB‐OEG in primates to determine their suitability for spinal cord transplantation.
Rubio Rodríguez, María Paz +2 more
openaire +3 more sources
Advanced Functional Materials, Volume 35, Issue 45, November 5, 2025.Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu +7 more
wiley +1 more source