Results 61 to 70 of about 1,587 (178)
Olfactory Ensheathing Glia and Spinal Cord Injury: Basic Mechanisms to Transplantation
Future Neurology, 2006 The adult CNS, unlike its counterpart the peripheral nervous system (PNS), has little ability to repair itself after traumatic injury. Therefore, neurotrauma involving the brain or spinal cord has severe and long-lasting functional consequences for injured patients, as well as a massive financial and social impact on the affected families and the ...
Alan R Harvey, Giles W Plant
openaire +1 more source
Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells
BioEssays, Volume 47, Issue 11, November 2025.Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley +1 more source
Secretome Profiling in Axon Regeneration: Emerging Techniques and Therapeutic Translation
Sensory Neuroscience, Volume 1, Issue 2, September 2025.ABSTRACT The secretome refers to the in vivo ensemble of molecular entities that are found in interstitial spaces. It is then the mere secreted products of the cells, as all biomolecules in the interstitial cellular spaces also undergo modifications. The fractionated secretome may hold potential as a cell‐free therapy option due to its role in tissue ...
Maria D. Cabrera +3 more
wiley +1 more source
Repopulating Microglia Suppress Peripheral Immune Cell Infiltration to Promote Poststroke Recovery
CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.PLX5622 treatment during the acute phase of tMCAO reshapes the immune microenvironment. The repopulated microglia adopt a homeostatic phenotype, contributing to improved blood–brain barrier integrity and inhibiting the recruitment of peripheral immune cells.
Ligen Shi +8 more
wiley +1 more source
Glia, 2009 AbstractA continuous normal function of olfactory ensheathing glia (OEG) is to promote axonal regeneration from the olfactory neuroepithelium to the brain, and their neuroregenerative potential in other CNS sites such as the injured spinal cord has been studied for over a decade. However, human OEG are difficult to obtain in large amounts directly from
Lim, Filip +8 more
openaire +3 more sources
Tracing Early Migratory Neurons in the Developing Nose Using Contactin‐2 (Cntn2) CreERT2
genesis, Volume 63, Issue 4, August 2025.ABSTRACT Neuronal migration during embryonic development is a fundamental process. In the developing nose of rodents, neurons that form during early neurogenic waves in the olfactory placode leave this structure to migrate toward or into the developing brain as part of the migratory mass.
Enrico Amato Jr. +2 more
wiley +1 more source
Journal of Biomedical Science, 2017 Background Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration.
May-Jywan Tsai +14 more
doaj +1 more source
Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis
Cell Proliferation, Volume 58, Issue 8, August 2025.Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu +7 more
wiley +1 more source
Journal of Neurorestoratology, 2013 Zhicheng Zhang, Fang Li, Tiansheng Sun, Dajiang Ren, Xiumei Liu PLA Institute of Orthopedics, Beijing Army General Hospital, Beijing, People's Republic of China Background: Many previous studies have focused on the effects of IN-1, a monoclonal ...
Zhang Z, Li F, Sun T, Ren D, Liu X
doaj
Neural Stem Cell‐Derived Extracellular Vesicles for Advanced Neural Repair
Journal of Neurochemistry, Volume 169, Issue 8, August 2025.Neurodegenerative and neuroinflammatory diseases, such as Alzheimer's and multiple sclerosis (MS), are characterized by inflammation, nerve cell damage, and a limited capacity for natural repair, which worsens with aging. While neural stem cells (NSCs) show promise for brain repair, their clinical use is limited by safety and delivery challenges.
Eduardo H. Moretti +4 more
wiley +1 more source