Results 91 to 100 of about 388,373 (393)

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, EarlyView.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William, Dufès, Christine, Gaillard, Afsaneh, Gaillard, Frédéric, Muller, Jean-Marc, Olivier, Jean-Christophe   +5 more
core   +1 more source

Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium

Journal of Neuroscience, 2015
The olfactory epithelium (OE) is one of the few tissues to undergo constitutive neurogenesis throughout the mammalian lifespan. It is composed of multiple cell types including olfactory sensory neurons (OSNs) that are readily replaced by two populations ...
Ariell M Joiner, W. Green, Jeremy C. McIntyre, Benjamin L. Allen, J. Schwob, J. Martens   +5 more
semanticscholar   +1 more source

Extent of Resection and Role of Adjuvant Radiotherapy in Olfactory Neuroblastoma Without Definite Radiologic Evidence of Dural Invasion

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Objectives To evaluate the impact of the extent of resection and adjuvant radiotherapy (RT) on treatment outcomes in patients with early‐stage olfactory neuroblastoma (ONB) without definite dural invasion. Methods A retrospective review of ONB cases from two centers within a single institution between 1992 and 2023 was performed ...
Tae‐Bin Won, Minju Kim, Sung‐Woo Cho, Doo Hee Han, Hyun Jik Kim, Dong‐Young Kim, Chae‐Seo Rhee, Kihwan Hwang, Sun Ha Paek   +8 more
wiley   +1 more source

Hendra and Nipah Virus Infection in Cultured Human Olfactory Epithelial Cells

mSphere, 2017
Henipaviruses are emerging zoonotic viruses and causative agents of encephalitis in humans. However, the mechanisms of entry into the central nervous system (CNS) in humans are not known.
Viktoriya Borisevich, Mehmet Hakan Ozdener, Bilal Malik, Barry Rockx   +3 more
doaj   +1 more source

Adiponectin enhances the responsiveness of the olfactory system. [PDF]

PLoS ONE, 2013
The peptide hormone adiponectin is secreted by adipose tissue and the circulating concentration is reversely correlated with body fat mass; it is considered as starvation signal.
Diana Loch, Christian Heidel, Heinz Breer, Jörg Strotmann   +3 more
doaj   +1 more source

Olfactory Impairment and Incident Cognitive Decline: A Systematic Review and Meta‐Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory impairment (OI) is associated with poor ageing outcomes. While cross‐sectional studies found a high prevalence of OI among patients with neurodegenerative diseases, the temporal relationship remains unclear. This meta‐analysis aims to synthesise the longitudinal association of OI with cognitive decline (CD). Methods PubMed,
Brian Sheng Yep Yeo, Harris Jun Jie Muhammad Danial Song, Benjamin Kye Jyn Tan, Adithya Suresh, Owen Tsung Wen Ho, Jun He Chan, Esther Yanxin Gao, Claire Jing‐Wen Tan, Chong Boon Teo, Christopher Li‐Hsian Chen, Laura Tay, Ecosse L. Lamoureux, Thomas Hummel, Anna See, Shuhui Xu, Song Tar Toh, Tze Choong Charn, Neville Wei Yang Teo   +17 more
wiley   +1 more source

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics. [PDF]

, 2018
BackgroundSingle-cell transcriptomics allows researchers to investigate complex communities of heterogeneous cells. It can be applied to stem cells and their descendants in order to chart the progression from multipotent progenitors to fully ...
Das, Diya, Dudoit, Sandrine, Fletcher, Russell B, Ngai, John, Purdom, Elizabeth, Risso, Davide, Street, Kelly, Yosef, Nir   +7 more
core   +2 more sources

Expression of connexin 57 in the olfactory epithelium and olfactory bulb [PDF]

Neuroscience Research, 2011
In the visual system, deletion of connexin 57 (Cx57) reduces gap junction coupling among horizontal cells and results in smaller receptive fields. To explore potential functions of Cx57 in olfaction, in situ hybridization and immunohistochemistry methods were used to investigate expression of Cx57 in the olfactory epithelium and olfactory bulb ...
openaire   +3 more sources

Elezanumab Accelerates Post‐Injury Regeneration of Olfactory Sensory Neurons in a Methimazole‐Induced Mouse Model

International Forum of Allergy &Rhinology, EarlyView.
Key Points Elezanumab accelerates olfactory sensory neuron regeneration in a methimazole‐induced mouse model. Repulsive guidance molecule A blockade increases GAP43+ and OMP+ cells dorsally while sparing basal cells. This approach offers a novel therapy for sensorineural olfactory disorder.
Eri Mori, Rumi Ueha, Hirotaka Tanaka, Hironobu Nishijima, Masayoshi Kobayashi, Nobuyoshi Otori, Kenji Kondo   +6 more
wiley   +1 more source