Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection
BioEssays, EarlyView.Embryonic radial glia (RG) generate neurons, glial cells, and later adult neural stem cells, which sustain adult neurogenesis (top, left to right). Human‐specific genetic modifications (blue arrow), selected to boost early RG neurogenic activity, may lead to premature RG exhaustion and reduced adult neurogenesis in the human brain (bottom).
David Morizet, Laure Bally‐Cuif
wiley +1 more source
Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors [PDF]
, 2001 E Woodhall +2 more
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What Epigenetics Teaches Us About Neuron–Glioma Interactions
BioEssays, EarlyView.Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense and respond to neural signals. Targeting the epigenetic machinery that facilitates this neuron–glioma crosstalk provides a strategy to disrupt the neural ...
Chaitali Chakraborty +2 more
wiley +1 more source
Characterization of olfactory nerve abnormalities in Twirler mice [PDF]
, 2001 Siew-Ging Gong
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ChemMedChem, EarlyView.The synthesis of a new series of 4,5‐dihydrothiazol‐2‐ylphenylpiperazine derivatives as serotoninergic ligands is described and tested for their affinity toward 5‐HT1A, 5‐HT2A,and 5‐HT2C and selected for further in vivo assays to determine their functional activity. The pharmacological studies highlight that among the developed derivatives, FG‐7 and FG‐
Giorgia Andreozzi +18 more
wiley +1 more source
Atrial Natriuretic Peptide Type C Induces a Cell-Cycle Switch from Proliferation to Differentiation in Brain-Derived Neurotrophic Factor- or Nerve Growth Factor-Primed Olfactory Receptor Neurons [PDF]
, 2002 P. Jeanette Simpson +5 more
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Manganese Neurotoxicity and Familial Disorders of Manganese Transport
Annals of the Child Neurology Society, EarlyView.ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley +1 more source
A comparative study oıı the histomorphology of olfactory bulb in greyhound and outdoor dog [PDF]
Eurasian Journal of Veterinary SciencesIn the present study, ollactory bulbs of greyhound and outdoor dogs were compared histologically. It was found that the olfactory bulbs of both species were constituted by accessory and main parts having the same layers (nerve, glomerular, eksternal ...
Mehmet Kanter
doaj
Diagnostic Accuracy of MRI-Based Morphometric Parameters for Detecting Olfactory Nerve Dysfunction. [PDF]
AJNR Am J Neuroradiol, 2020 Lee MK +10 more
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Transplanted Olfactory Ensheathing Cells Promote Regeneration of Cut Adult Rat Optic Nerve Axons [PDF]
, 2003 Ying Li +4 more
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