Results 201 to 210 of about 58,593 (265)

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

Ca²⁺-activated Cl^- current ensures robust and reliable signal amplification in vertebrate olfactory receptor neurons. [PDF]

Proc Natl Acad Sci U S A, 2019
Reisert J, Reingruber J.
europepmc   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

The impact of artificial light at night on moths (Lepidoptera, Heterocera): A review of the literature and future research directions

Conservation Science and Practice, EarlyView.
Artificial Light At Night (ALAN) is an emerging environmental issue with significant impacts on nocturnal insects, particularly nocturnal Lepidoptera. We conducted a systematic review addressing the effects of ALAN on insects, with a focus on nocturnal Lepidoptera.
Denise Trombin, Luca Dessì, Simona Bonelli   +2 more
wiley   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Detection and localization of the thyroid hormone receptor beta mRNA in the immature olfactory receptor neurons of chum salmon. [PDF]

Heliyon, 2018
Kudo H, Eto A, Abe T, Mochida K.
europepmc   +1 more source

She Doesn't Whisper: Female‐Prominent Stridulation Shaped by Morphology in a Buthid Scorpion and Insights on Its Function

Ethology, EarlyView.
Sexual dimorphism and stress‐induced stridulatory responses in Jaguajir rochae (Borelli, 1910). Females exhibited greater absolute pectinal size and higher sound pressure levels, whereas males showed higher pectinal allometric ratios relative to body size, lower sound frequencies, and shorter delta times.
Welton Dionisio‐da‐Silva, Natália Maria Câmara Luna, Patrício Adriano da Rocha, Rodrigo Hirata Willemart, Marcio Bernardino daSilva   +4 more
wiley   +1 more source

Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae. [PDF]

Sci Rep, 2018
Utashiro N, Williams CR, Parrish JZ, Emoto K.   +3 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Distinctive gene expression in the reduced first thoracic legs of a nymphalid butterfly

Insect Molecular Biology, EarlyView.
Transcriptome analysis reveals that the small non‐walking front legs of a butterfly have distinct gene expression to the four walking legs. Reduced front legs express a gene with putative mechanosensory roles, a blue‐sensitive opsin and two homeobox genes.
Asia E. Hoile, Peter O. Mulhair, Peter W. H. Holland   +2 more
wiley   +1 more source