Results 41 to 50 of about 259,025 (282)

The olfactory pathway in the peracarid crustacean Parhyale hawaiensis (Malacostraca): new insights into the evolution of olfactory processing in Pancrustacea

Open Biology
Our current understanding of the functional morphology of olfactory systems in arthropods largely relies on information obtained in hexapods. Existing analyses of the olfactory pathway in crustacean representatives have suggested that these animals share
Katja Kümmerlen, Rabea Schlüter, Steffen Harzsch   +2 more
doaj   +1 more source

Nasal Placode Development, GnRH Neuronal Migration and Kallmann Syndrome

Frontiers in Cell and Developmental Biology, 2019
The development of Gonadotropin releasing hormone-1 (GnRH) neurons is important for a functional reproduction system in vertebrates. Disruption of GnRH results in hypogonadism and if accompanied by anosmia is termed Kallmann Syndrome (KS).
Hyun-Ju Cho, Yufei Shan, Niteace C. Whittington, Susan Wray   +3 more
doaj   +1 more source

Inhibition of oxidative stress in cholinergic projection neurons fully rescues aging-associated olfactory circuit degeneration in Drosophila

eLife, 2018
Loss of the sense of smell is among the first signs of natural aging and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Cellular and molecular mechanisms promoting this smell loss are not understood.
Ashiq Hussain, Atefeh Pooryasin, Mo Zhang, Laura F Loschek, Marco La Fortezza, Anja B Friedrich, Catherine-Marie Blais, Habibe K Üçpunar, Vicente A Yépez, Martin Lehmann, Nicolas Gompel, Julien Gagneur, Stephan J Sigrist, Ilona C Grunwald Kadow   +13 more
doaj   +1 more source

Sequential Sparsening by Successive Adaptation in Neural Populations [PDF]

, 2009
In the principal cells of the insect mushroom body, the Kenyon cells (KC), olfactory information is represented by a spatially and temporally sparse code.
C Assisi, E Muller, Eilif Muller, Farzad Farkhooi, Martin P Nawrot, S Krofczik   +5 more
core   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Glomerular Organization of the Antennal Lobes of the Diamondback Moth, Plutella xylostella L.

Frontiers in Neuroanatomy, 2019
The antennal lobe of the moth brain is the primary olfactory center processing information concerning pheromones and plant odors. Plutella xylostella is a major worldwide pest of cruciferous vegetables and its behavior is highly dependent on their ...
Xizhong Yan, Zhiyu Wang, Jiaoxin Xie, Caiping Deng, Xuejun Sun, Xuejun Sun, Chi Hao   +6 more
doaj   +1 more source

The role of two anatomically separate olfactory bulbs in shark food odor tracking [PDF]

, 2017
Most sharks have well-developed olfactory systems and depend to a large degree on odor information to locate food, home and navigate, and possibly detect predators and mates.
Lohe, Adrienne
core   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM, Gonzalez-Martinez, D, Guimond, S, Hu, YL, Kim, SH, Schofield, J, Turnbull, J, Vannelli, GB, Winyard, P   +8 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Hypothalamus-Olfactory System Crosstalk: Orexin as a Connecting Track in Mice.

Frontiers in Neuroanatomy, 2012
It is well known that olfaction influences food intake, and almost vice versa, the nutritional status of individuals modulates olfactory sensitivity. However, the neuronal correlate of this relationship and the connections between the olfactory bulb and ...
Jean eGascuel, Jean eGascuel, Jean eGascuel, Aleth eLemoine, Aleth eLemoine, Aleth eLemoine, Caroline eRigault, Caroline eRigault, Caroline eRigault, Frédérique eDatiche, Frédérique eDatiche, Frédérique eDatiche, Alexandre eBenani, Alexandre eBenani, Alexandre eBenani, Luc ePénicaud, Luc ePénicaud, Luc ePénicaud, Laura eLópez-Mascaraque   +18 more
doaj   +1 more source