Results 91 to 100 of about 62,007 (257)

Olfactory threshold and odor discrimination ability in children – evaluation of a modified “Sniffin’ Sticks” test

Scientific Reports, 2017
The clinical diagnostics of olfactory dysfunction in children turns out to be challenging due to low attention span, insufficient linguistic development and lack of odor experiences. Several smell tests have been developed for adults.
Janine Gellrich, Carolin Stetzler, Anna Oleszkiewicz, Thomas Hummel, Valentin A. Schriever   +4 more
doaj   +1 more source

A 32-Year-Old Man with Persistent Olfactory Dysfunction Following COVID-19 Whose Recovery Was Evaluated by Retronasal Olfactory Testing. [PDF]

Am J Case Rep, 2022
Hirano K, Tanaka Y, Kamimura S, Suzaki I, Suzuki E, Kobayashi H.   +5 more
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Success in the Natural Detection Task is influenced by only a few factors generally believed to affect dogs’ olfactory performance

Scientific Reports
Research into dogs' olfactory ability is growing rapidly. However, generalising based on scientific results is challenging, because research has been typically conducted on a few specially trained subjects of a few breeds tested in different ...
Attila Salamon, Eszter Baranya, László Róbert Zsiros, Ádám Miklósi, Melitta Csepregi, Enikő Kubinyi, Attila Andics, Márta Gácsi   +7 more
doaj   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Olfactory Testing in Parkinson Disease and REM Behavior Disorder: A Machine Learning Approach. [PDF]

Neurology, 2021
Lo C, Arora S, Ben-Shlomo Y, Barber TR, Lawton M, Klein JC, Kanavou S, Janzen A, Sittig E, Oertel WH, Grosset DG, Hu MT.   +11 more
europepmc   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Mechanisms, diagnosis, and treatment of olfactory dysfunction in rhinosinusitis

European Journal of Medical Research
Background Olfactory dysfunction is a common symptom of chronic rhinosinusitis (CRS), affecting approximately 60–80% of patients. This impairment significantly impacts patients' quality of life and increases the risk of hazardous events.
Hai Zhu, Siyuan Qu, Mengdan Gong, Yizhen Xiang, Shengqi Gan, Yaoshu Teng, Dong Ye   +6 more
doaj   +1 more source

The impact of nicotine on the olfactory memory and its relationship with TRPA1

iScience
Summary: Olfactory disorders are related to cognitive decline, yet effective treatments remain limited. Cigarette smoke impairs olfaction, but one of its components, nicotine, can protect nerve cells in the central nervous system.
Kazuya Mizobata, Hideki Sakatani, Masamitsu Kono, Shizuya Saika, Akinori Akaike, Muneki Hotomi   +5 more
doaj   +1 more source